Short courses of intravenous empirical antibiotic treatment in selected febrile neutropenic children with cancer.

Abstract:

BACKGROUND:Since the optimal duration of antibiotic therapy in febrile neutropenic patients is not clear, we evaluated the safety and efficacy of short courses of intravenous antibiotic treatment in selected pediatric cancer patients admitted for fever and neutropenia. PATIENTS AND METHODS:We retrospectively analyzed the clinical course of children with chemotherapy-induced neutropenia and fever. All patients were treated with empirical intravenous antibiotics. In episodes of fever of unknown origin (FUO), treatment regimen allowed discontinuation of antibiotics and early hospital discharge regardless of absolute neutrophil count (ANC) or evidence of bone marrow recovery as long as patients were afebrile for at least 24 h and had been treated for a minimum of 72 h. RESULTS:106 episodes of febrile neutropenia occurred in 56 patients. 84 episodes were classified as FUO and intravenous antibiotic therapy was discontinued regardless of ANC when patients met the criteria described above. No death or major complication occurred. None of the patients had to be rehospitalized for recurrent fever or infection. CONCLUSION:Discontinuation of intravenous antibiotics regardless of ANC or evidence of bone marrow recovery seems safe and effective in pediatric cancer patients with FUO when children are afebrile for at least 24 h and are treated for a minimum of 72 h.

journal_name

Infection

journal_title

Infection

authors

Lehrnbecher T,Stanescu A,Kühl J

doi

10.1007/s15010-002-2094-1

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

17-21

issue

1

eissn

0300-8126

issn

1439-0973

journal_volume

30

pub_type

临床试验,杂志文章
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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1007/BF01643684

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    pub_type: 杂志文章

    doi:10.1007/BF01641100

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    pub_type: 杂志文章

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    更新日期:1979-01-01 00:00:00

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    pub_type: 杂志文章

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    journal_title:Infection

    pub_type: 杂志文章

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    pub_type: 杂志文章

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02113499

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    更新日期:1997-01-01 00:00:00

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    pub_type: 杂志文章,评审

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    更新日期:1991-01-01 00:00:00

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    journal_title:Infection

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1007/s15010-002-3066-1

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    更新日期:2003-01-01 00:00:00

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0737-2

    authors: Origüen J,Fernández-Ruiz M,Lumbreras C,Orellana MÁ,López-Medrano F,Ruiz-Merlo T,San Juan R,García-Reyne A,González E,Polanco N,Paz-Artal E,Andrés A,Aguado JM

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    pub_type: 杂志文章

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    更新日期:1979-01-01 00:00:00

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    pub_type: 杂志文章

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