[Effect of pH value and magnesium on the antibacterial activity of quinolone preparations].

Abstract:

:The activity of ten different 4-quinolone antibacterial agents against Escherichia coli KL16 was investigated at four pH values between 5.6 and 8.3, which is the pH range of urine. It was found that pH affected the minimum inhibitory concentrations of all the drugs, but the nature of the substituent at the C7 position of each 4-quinolone governed how its activity was altered by the hydrogen ion concentration. When a 4-quinolone possessed a piperazine group at its C7 position its activity became progressively less as the pH fell. However, all drugs that lacked a C7 piperazine, irrespective of the nature of their substituent at this position, exhibited a progressive increase in activity as the pH was reduced. In addition it was found that, excepting cinoxacin, a urinary concentration of magnesium generally caused a further antagonism of the activity of the nine other 4-quinolone antibacterials at all pH values tested.

journal_name

Infection

journal_title

Infection

authors

Smith JT,Ratcliffe NT

doi

10.1007/BF01645195

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

S31-5

eissn

0300-8126

issn

1439-0973

journal_volume

14 Suppl 1

pub_type

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  • The binding of Chlamydia trachomatis and zinc to McCoy cells (mouse fibroblasts).

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    doi:10.1007/BF01640763

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    更新日期:1982-01-01 00:00:00

  • IFN-alpha: therapeutic options in HIV and HIV/HCV, HIV/HBV dual infection.

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    doi:

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    更新日期:2000-03-01 00:00:00

  • Efficacy of clarithromycin in preventing viridans streptococcal bacteremia following autologous stem cell transplantation.

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  • [Efficacy and tolerance of imipenem/cilastatin in the treatment of surgical infections with and without bone involvement].

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    pub_type: 杂志文章

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  • Non-fermentative Gram-negative rods bacteremia in children with cancer: a 14-year single-center experience.

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  • Factors indicative of outcome in a comparative trial of acyclovir and vidarabine for biopsy-proven herpes simplex encephalitis.

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    doi:10.1007/BF01644946

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