Abstract:
:Forty-six consecutive patients with pneumococcal meningitis were treated with cefotaxime (CTX). Ages ranged from 1-79 years: 29 adults, six adolescents, six children and five infants. Underlying diseases were found in 38 patients (82.6%). Twenty-six patients (56.5%) were admitted in coma. All isolates were sensitive to CTX, with MICs for 12 strains ranging from 0.01 to 0.08 mg/l. CTX was used as single-drug therapy for 12 to 27 days-mean 15 days. The daily dose of CTX was 200 mg/kg, in four or six equal intravenous doses. CTX penetration into the CSF was studied in four patients. 40 patients (87.0%) were cured. The mortality rate was 13.0%. All dead patients had been admitted in coma. The mortality rate in comatose patients was 23.1%. CSF sterilization was obtained within 72 h after starting treatment, mostly (90.7%) in the first 48 h. No serious side-effects were observed. The study proves that CTX is a safe and very successful therapy for pneumococcal meningitis.
journal_name
Infectionjournal_title
Infectionauthors
Lecour H,Seara A,Miranda AM,Cordeiro Jdoi
10.1007/BF01644223subject
Has Abstractpub_date
1985-01-01 00:00:00pages
S73-5eissn
0300-8126issn
1439-0973journal_volume
13 Suppl 1pub_type
杂志文章相关文献
INFECTION文献大全abstract:BACKGROUND:Loxoscelism is an envenomation due to a bite by spiders of the genus Loxosceles, very well known on the American continent but unrecognized in Europe. CASE REPORT:We report the case of a 36-year-old woman, without any medical history or treatment, who went to a University Hospital in the South of France, fo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0869-4
更新日期:2016-06-01 00:00:00
abstract::Cydnidae bug (also termed the burrowing bug) are arthropods of the order Hemiptera, that are recognized by their morphological adaptations for digging. They release an odorous substance from special glands that serve as self-defense, causing pigmented macules when in contact with human skin, especially during the rain...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01481-w
更新日期:2020-07-11 00:00:00
abstract::The pharmacokinetics and renal excretion of the sulphonamides sulphachloropyridazine, sulphadiazine, sulphaisodimidine, sulphamerazine, and sulphamethoxazole were investigated in a cross-over study with doses of 800 mg each. The serum half-life, urine levels, distribution volume, protein binding and potential antibact...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01639015
更新日期:1979-01-01 00:00:00
abstract::There is a correlation between tissue oxygen tension, incidence of infection and disturbance of wound healing. Scientific investigations in recent years have documented that infection and tissue repair are processes consuming oxygen. Animal experiments have shown that oxygenation of the tissue is essential for the eli...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01660413
更新日期:1985-03-01 00:00:00
abstract::Here, we present a case of an immunocompetent 37-year old male who developed Aspergillus fumigatus osteomyelitis 16 years after extensive chest wall reconstructive surgery for Ewing sarcoma. His treatment course was complicated by a severe adverse drug reaction to voriconazole, requiring the use of oral posaconazole t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01489-2
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:Investigation of the injecting drug users (IDUs) population is becoming extremely critical and timely in light of the recent evidence that IDUs now act as the core of hepatitis C virus (HCV) epidemics in developed countries. The purpose of this article, therefore, is not only to review the epidemiology of HCV i...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-011-0236-z
更新日期:2012-02-01 00:00:00
abstract::A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644192
更新日期:1987-01-01 00:00:00
abstract::A 62-year-old man developed a blood stream infection and meningitis due to Listeria monocytogenes, 20 days after an episode of pseudo-membranous colitis. The patient, hospitalized for the first time for transurethral prostatectomy, was readmitted 20 days later with watery diarrhea. Pseudo-membranous colitis was diagno...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1013-4
更新日期:2017-06-01 00:00:00
abstract::The situation of clinical research in Europe must be improved substantially according to statements of scientists, managers and politicians. The analysis of requirements is available; however, there are no indications that the conclusion of the analysis is being converted into actual facts. Government programs, althou...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02962265
更新日期:1998-09-01 00:00:00
abstract:PURPOSE:In January 2015, we noticed by rectal swab analyses that seven of 23 patients at an early rehabilitation ward had been colonized with carbapenem-resistant Klebsiella pneumoniae (CKP). Here, we describe risk factors for CKP acquisition. METHODS:In the present study, the outbreak is described and risk factors fo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-017-1103-3
更新日期:2018-02-01 00:00:00
abstract::Efficacy of Oral Ofloxacin and Ciprofloxacin. Cross-over Study. The efficacy of the 4-quinolones ciprofloxacin (CPX) and ofloxacin (OFX) was studied in a cross-over study. Twenty out-patients with cystic fibrosis and chronic colonization of the respiratory tract with Pseudomonas aeruginosa were treated for ten days wi...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01645207
更新日期:1986-01-01 00:00:00
abstract::A 6-month prospective surveillance was conducted in the Department of General Surgery of the Rio de Janeiro University Hospital. Postoperative infections were classified according to CDC criteria. This study reports a significant rate (16.9%) in surgical infections detected by surveillance in a series where 45% of sur...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713147
更新日期:1997-07-01 00:00:00
abstract:OBJECTIVE:"Choosing Wisely" is a growing international campaign aiming at practice changes to improve patient health and safety by both, conduct of essential and avoidance of unnecessary diagnostic, preventive and therapeutic procedures. The goal is to create an easily recognizable and distributable list ("Choosing Wis...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-017-0997-0
更新日期:2017-06-01 00:00:00
abstract::Dysbiosis does not necessarily mean disease. Typical clinical picture of disease caused by metabolic activity of dysbiotic microflora is the microbial over-growth syndrome. We studied case histories of 434 patients without consideration of their basic illnesses and correlated them with types of dysbioses of duodenal j...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01639535
更新日期:1989-07-01 00:00:00
abstract::A rare case of spontaneous spondylodiscitis caused by Klebsiella pneumoniae in a 55-year-old man who presented with thoracolumbar pain is described. Increased erythrocyte sedimentation rate and C-reactive protein level were pertinent laboratory findings. Computed tomography revealed a paravertebral mass and destructio...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s150100050046
更新日期:1999-11-01 00:00:00
abstract:PURPOSE:To reduce intensive care unit overcrowding and optimize resources, elderly patients affected by suspected infection with declining clinical conditions could be managed in internal medicine departments with stepdown beds. However, commonly used prognostic scores, as Sequential Organ Failure Assessment (SOFA) or ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-020-01494-5
更新日期:2020-12-01 00:00:00
abstract:PURPOSE:To identify reversible risk factors for Clostridium difficile infection (CDI) after kidney transplantation (KT) that could lead to a reduction in its incidence and associated complications. METHODS:We performed a single-center case-control study in which 41 patients undergoing KT between February 2009 and July...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0737-2
更新日期:2015-08-01 00:00:00
abstract::Thirty patients suffering from bacteriogenic skin diseases were given cefaclor, in most cases simultaneously with classical external dermatological therapy. The results of therapy were satisfactory in 29 of the 30 patients. Only in one relatively severe case of erysipelas did the disease continue to spread despite the...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659751
更新日期:1979-01-01 00:00:00
abstract::In a randomized controlled, clinical study the efficacy of ceftazidime at a dosage of 2 g b. i. d. was compared to that of cefotaxime at a dosage of 2 g t. i. d. or more in the treatment of pneumonia or peritonitis in intensive care patients. 61 of 67 assessable cases were evaluable. In the ceftazidime group ten out o...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01645865
更新日期:1987-01-01 00:00:00
abstract::The most efficient route of transmission of hepatitis C virus (HCV) infection is through contaminated blood. Sexual transmission or other close human contact could play a role in sporadic infections. We describe a case of acute hepatitis C progressing to chronic hepatitis over a follow-up of 4 years in a 44-year-old w...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-007-6188-7
更新日期:2007-12-01 00:00:00
abstract::A 47-year-old man with newly diagnosed acute myeloblastic leukemia and non-insulin-dependent diabetes mellitus developed Trichosporon asahii fungemia while receiving caspofungin as empirical antifungal therapy. The diagnosis was based on repeated isolation of T. asahii in culture of blood for three times. Despite trea...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6278-6
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Out of 2,560 participants in an epidemiological survey of alveolar echinococcosis (AE) performed in 1996 in southwestern Germany, 47 participants had tested seropositive in one of two crude antigen screening ELISAs and were inconspicuous on hepatic ultrasound. PATIENTS AND METHODS:Out of these 47 seroreacto...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1153-3
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Home intravenous antibiotic treatment has added to therapeutic options against Pseudomonas aeruginosa in cystic fibrosis (CF) patients leading to increased flexibility. A prospective clinical study was carried out to compare home and hospital iv antibiotic treatment in CF patients with chronic P. aeruginosa ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-002-2095-0
更新日期:2002-12-01 00:00:00
abstract::A case of meningitis due to an unusual organism, Haemophilus aphrophilus in an adult is described. In spite of rapid clearance of the organism from the cerebrospinal fluid with intravenous cefotaxime, fever persisted over 8 days of therapy and infection was complicated by hydrocephalus. H. aphrophilus meningitis is un...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF02770846
更新日期:1998-11-01 00:00:00
abstract::In a randomized clinical study, 61 hospitalized men were examined to test the local tolerability and antimicrobial efficacy of antiseptic treatment of the genitals with povidone iodine versus octenidine hydrochloride solution. Antibacterial efficacy was established by comparing the total aerobic bacterial colony count...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF02560508
更新日期:1999-03-01 00:00:00
abstract:PURPOSE:This narrative review aims to describe barriers of outpatient parenteral antimicrobial therapy at home (OPAT), potentially compromising general standards of antibiotic stewardship (ABS) and facilitators of OPAT for ABS. METHODS:After a literature review, five authors determined the barriers and facilitators to...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-018-1250-1
更新日期:2019-04-01 00:00:00
abstract::The agar diffusion method was used to test the antibacterial efficacy of cefaclor against bacterial strains isolated routinely from patients in two hospitals in Berlin. A comparison was made with the efficacy of oxacillin, azlocillin, amikacin, gentamicin, ampicillin, co-trimoxazole, tetracycline, penicillin, cefazoli...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01659732
更新日期:1979-01-01 00:00:00
abstract::Turicella otitidis and Corynebacterium auris, described as new species 20 years ago, have been isolated mainly from the external ear canal and middle ear fluid. While their taxonomic position has been clearly established, their diagnosis in the routine laboratory is difficult. The question of their pathogenic potentia...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-013-0488-x
更新日期:2014-02-01 00:00:00
abstract::The prevalence of anti-HCV antibodies and the risk factors for HCV infection were assessed in 5,672 pregnant women living in North Italy. All reactive sera were confirmed by RIBA-2 test. Anti-HCV positive pregnant women together with an anti-HCV negative control group, were interviewed by standardised questionnaire to...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01715541
更新日期:1994-09-01 00:00:00
abstract:PURPOSE:To evaluate the impact of the International Nosocomial Infection Control Consortium (INICC) multidimensional approach on the reduction of ventilator-associated pneumonia (VAP) in adult patients hospitalized in 11 intensive care units (ICUs), from 10 hospitals, members of the INICC, in 10 cities of Turkey. METH...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s15010-013-0407-1
更新日期:2013-04-01 00:00:00