Breakthrough Trichosporon asahii fungemia in neutropenic patient with acute leukemia while receiving caspofungin.

Abstract:

:A 47-year-old man with newly diagnosed acute myeloblastic leukemia and non-insulin-dependent diabetes mellitus developed Trichosporon asahii fungemia while receiving caspofungin as empirical antifungal therapy. The diagnosis was based on repeated isolation of T. asahii in culture of blood for three times. Despite treatment with amphotericin B and voriconazole, the patient died. The in vitro antifungal susceptibilities of the T. asahii isolates were only available after the patient died. In vitro antifungal susceptibility tests showed high caspofungin and amphotericin B minimal inhibitory concentrations (MICs) value for this Trichosporon strain (MICs, 16 microg/ml, and>32 microg/ml, respectively). Fluconazole, itraconazole, and voriconazole exhibited low MICs in vitro (MICs, 4 microg/ml, 0.5 microg/ml, and

journal_name

Infection

journal_title

Infection

authors

Bayramoglu G,Sonmez M,Tosun I,Aydin K,Aydin F

doi

10.1007/s15010-007-6278-6

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

68-70

issue

1

eissn

0300-8126

issn

1439-0973

journal_volume

36

pub_type

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