Further methodological improvement in antibiotic bone concentration measurements: penetration of ofloxacin into bone and cartilage.

Abstract:

:Ten patients (mean age 63 years) undergoing alloarthroplastic hip joint replacement received 400 mg ofloxacin orally before anaesthesia. Venous blood samples were obtained before administration of the drug and then at intervals of up to 24 h. Bone samples were taken from femoral head and femoral shaft. Antibiotic concentrations were assessed by means of HPLC. The maximum serum concentration was 3.45 mg/l on average, after 90 min, and the maximum average bone concentration was 1.22 mg/l after 270 min. The half-life of ofloxacin in bone was shorter than that in serum. The concentrations measured in bone were superior to the minimal inhibitory concentrations reported for most pathogens of bone and joint infections. Therefore ofloxacin appears to be a valuable contribution to the therapeutic options of oral treatment for bone and joint infections.

journal_name

Infection

journal_title

Infection

authors

Wittmann DH,Kotthaus E

doi

10.1007/BF01661291

subject

Has Abstract

pub_date

1986-01-01 00:00:00

pages

S270-3

eissn

0300-8126

issn

1439-0973

journal_volume

14 Suppl 4

pub_type

杂志文章
  • Five cases of Plasmodium vivax malaria treated with artemisinin derivatives: the advantages of a unified approach to treatment.

    abstract:OBJECTIVES:In endemic countries with a high level of chloroquine resistance, Plasmodium vivax malaria is associated with high morbidity and mortality. In these areas, the dihydroartemisinin-piperaquine combination resulted in clinical response, a more rapid clearance of parasitaemia, compared to chloroquine therapies, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01286-6

    authors: Corpolongo A,Pisapia R,Oliva A,Giancola ML,Mencarini P,Bevilacqua N,Ghirga P,Mariano A,Vulcano A,Paglia MG,Nicastri E

    更新日期:2019-08-01 00:00:00

  • Emergence of SCCmec type IV as the most common type of methicillin-resistant Staphylococcus aureus in a university hospital.

    abstract:BACKGROUND:The epidemiology of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically changed over the last decade by the emergence of community-associated MRSA (CA-MRSA). Recent studies indicate that these strains have already spread to hospitals. To evaluate if SCCmec type IV and Panton-Valentine leukoci...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-008-7430-7

    authors: Strandén AM,Frei R,Adler H,Flückiger U,Widmer AF

    更新日期:2009-02-01 00:00:00

  • Prevalence of anti-HCV and risk factors for hepatitis C virus infection in healthy pregnant women.

    abstract::The prevalence of anti-HCV antibodies and the risk factors for HCV infection were assessed in 5,672 pregnant women living in North Italy. All reactive sera were confirmed by RIBA-2 test. Anti-HCV positive pregnant women together with an anti-HCV negative control group, were interviewed by standardised questionnaire to...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01715541

    authors: Marranconi F,Fabris P,Stecca C,Zampieri L,Bettini MC,Di Fabrizio N,de Lalla F

    更新日期:1994-09-01 00:00:00

  • Legionella bozemanii, an elusive agent of fatal cavitary pneumonia.

    abstract::A 67-year-old patient died of Legionella bozemanii pneumonia with negative urinary antigen and negative serology. Cystic lesions in pneumonia of unknown origin should lead to the differential diagnosis of L. bozemanii infections. ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6251-4

    authors: Widmer A,Hohl P,Dirnhofer S,Bassetti S,Marsch S,Frei R

    更新日期:2007-06-01 00:00:00

  • Efficacy of clarithromycin in preventing viridans streptococcal bacteremia following autologous stem cell transplantation.

    abstract:BACKGROUND:In a study involving 200 patients, we previously found that 17.5% of patients developed viridans streptococcal (VS) bacteremia following autologous peripheral blood stem cell transplantation (aPBSCT) when ciprofloxacin or ciprofloxacin plus ampicillin was used for prophylaxis. PATIENTS AND METHODS:A retrosp...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-1028-7

    authors: Naqvi B,Dorsky D,Ali SA,Feingold JM,Edwards RL,Bona RD,Clive J,Tutschka PJ,Bilgrami S

    更新日期:2001-08-01 00:00:00

  • [Effectiveness and tolerance of cefixime in bacterial infections in the ENT area].

    abstract::Clinical efficacy and tolerance of cefixime were investigated in an open, uncontrolled trial. 200 mg of cefixime were applied twice daily, duration of therapy was between eight and 14 days (mean value 10.1 days, standard deviation +/- 1.4 days). Ten male patients (mean age 42.7 years) and 19 female patients (mean age ...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01644629

    authors: Theopold M,Benner U,Bauernfeind A

    更新日期:1990-01-01 00:00:00

  • A standard immunoglobulin preparation produced from bovine colostra shows antibody reactivity and neutralization activity against Shiga-like toxins and EHEC-hemolysin of Escherichia coli O157:H7.

    abstract::Enterohemorrhagic Escherichia coli (EHEC) causes a variety of clinical conditions, the most important being hemorrhagic colitis and hemolytic uremic syndrome. A curative therapy of EHEC diseases is not yet feasible. This study investigates the antibody reactivity of Lactobin, a standardized immunoglobulin (Ig) prepara...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01716084

    authors: Lissner R,Schmidit H,Karch H

    更新日期:1996-09-01 00:00:00

  • Liposome-encapsulated ampicillin against Listeria monocytogenes in vivo and in vitro.

    abstract::In an experimental infection caused by Listeria monocytogenes in mice a considerable enhancement (90-fold) of the therapeutic activity of ampicillin resulting from liposomal encapsulation was observed. The mechanism by which liposomes improved the therapeutic index of ampicillin in this infection appeared to be an inc...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639742

    authors: Bakker-Woudenberg IA,Lokerse AF,Vink-van den Berg JC,Roerdink FH

    更新日期:1988-01-01 00:00:00

  • Reactivation of hepatitis C virus superinfection in a patient seropositive for hepatitis B e antigen.

    abstract::During the course of chronic hepatitis B virus (HBV) infection, a patient seropositive for hepatitis B e antigen experienced four episodes of acute hepatic necroinflammation. Serum HBV-DNA concentration elevated immediately before the first and third exacerbations, whereas serum hepatitis C virus (HCV) RNA was detecte...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-1195-6

    authors: Chen LW,Yeh CT,Fang KM,Chu CM,Liaw YF

    更新日期:2001-12-01 00:00:00

  • Chlamydia trachomatis: serological diagnosis.

    abstract::Satisfactory methods for the serodiagnosis of Chlamydia trachomatis have been widely discussed in recent years. Until a decade ago, the complement-fixation test measuring group-specific antibody was the most widely applied technique. However, despite showing relatively high diagnostic sensitivity in systemic chlamydia...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01640711

    authors: Treharne JD

    更新日期:1982-01-01 00:00:00

  • Specific anti cross-infection measures may help to prevent viral contamination of dental unit waterlines: a pilot study.

    abstract:BACKGROUND:In recent years, several reports have suggested, but never definitely demonstrated that dental units (DU) could be potential sources of viral cross-infections sustained by viral agents including HBV, HCV and HIV. This work aims at assessing the risk of HCV cross-infection by dental unit water lines (DUWLs). ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-008-7246-5

    authors: Artini M,Scoarughi GL,Papa R,Dolci G,De Luca M,Orsini G,Pappalardo S,Costerton JW,Selan L

    更新日期:2008-10-01 00:00:00

  • Serological biomarkers of candidemia: a retrospective evaluation of three assays.

    abstract:PURPOSE:Serologic testing allows for rapid detection of candidemia. More data are needed for the Virion\Serion ELISA antigen test (Ag), Hemkit Candida IHA antibody test (Ab), and Wako β-1,3-D-glucan assay (BDG). METHODS:Tests were performed on serum samples from 120 cases of culture-confirmed candidemia and 44 Candida...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1224-3

    authors: Dichtl K,Seybold U,Wagener J

    更新日期:2019-04-01 00:00:00

  • Single and multiple dose pharmacokinetics of intravenous cefpirome (HR 810), a novel cephalosporin derivative.

    abstract::After intravenous injection of single doses of 1.0 g of cefpirome (HR 810) and multiple doses of 1.0 g b.i.d. for five days to the same ten healthy male volunteers in an open design, concentrations of unchanged drug were estimated at various times in serum and urine, over 24 h and 48 h, respectively. Cefpirome concent...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01646053

    authors: Malerczyk V,Maass L,Verho M,Hajdú P,Klesel N,Rangoonwala R

    更新日期:1987-05-01 00:00:00

  • Hospital at home for the management of COVID-19: preliminary experience with 63 patients.

    abstract::Alternatives to conventional hospitalization are needed to increase health systems resilience in the face of COVID-19 pandemic. Herein, we describe the characteristics and outcomes of 63 patients admitted to a single HaH during the peak of COVID-19 in Barcelona. Our results suggest that HaH seems to be a safe and effi...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01527-z

    authors: Pericàs JM,Cucchiari D,Torrallardona-Murphy O,Calvo J,Serralabós J,Alvés E,Agelet A,Hidalgo J,Alves E,Castells E,Seijas N,Hernández C,Bodro M,Cardozo C,Coloma E,Nicolás D,Hospital Clínic 4H Team (Hospital at Home-Health H

    更新日期:2020-09-29 00:00:00

  • Onset of symptoms, diagnostic confirmation, and occurrence of multiple infective foci in patients with Staphylococcus aureus bloodstream infection: a look into the order of events and potential clinical implications.

    abstract:PURPOSE:Data on the systemic dissemination in Staphylococcus aureus bloodstream infection (SAB) remain sparse. We investigated the timing and the sequence of clinical symptoms, diagnostic confirmation, and occurrence of multiple infective foci in relation to three major infective foci. METHODS:From 2006 to 2011, all a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1165-x

    authors: Smit J,Rieg SR,Wendel AF,Kern WV,Seifert H,Schønheyder HC,Kaasch AJ

    更新日期:2018-10-01 00:00:00

  • Effect of dexamethasone and pentoxifylline in combination with amoxicillin in the treatment of penicillin-insensitive pneumococcal pneumonia in guinea pigs.

    abstract::A fatal guinea pig model of pneumococcal pneumonia was developed in order to evaluate the efficacy of amoxicillin combined with either pentoxifylline or dexamethasone. Parameters assessed were survival time and lung changes (alterations, bacterial colony counts, inducible nitric oxide synthase [iNOS] and cyclooxygenas...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2098-x

    authors: Parra A,García-Olmos M,Nieto E,García-Calvo G,Ponte C,Soriano F

    更新日期:2002-06-01 00:00:00

  • Long-term antibiotic treatment with roxithromycin in patients with multiple sclerosis.

    abstract:BACKGROUND:There are conflicting results concerning an association between Chlamydia pneumoniae and MS (multiple sclerosis). In the present study, we investigated a possible therapeutic option with antibiotics. PATIENTS AND METHODS:In our randomized, placebo-controlled double-blind study, 28 patients with the confirme...

    journal_title:Infection

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s15010-006-5114-8

    authors: Woessner R,Grauer MT,Frese A,Bethke F,Ginger T,Hans A,Treib J

    更新日期:2006-12-01 00:00:00

  • Non-typeable Haemophilus influenzae-associated early pregnancy loss: an emerging neonatal and maternal pathogen.

    abstract:OBJECTIVES:There is increasing evidence indicating an association between invasive non-typeable Haemophilus influenzae (NTHi) infection in pregnancy and early pregnancy loss. As the diagnosis relies on microbiological investigation of post-mortem placental and foetal samples, a significant proportion of NTHi-related pr...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-019-01359-6

    authors: Cevik M,Moncayo-Nieto OL,Evans MJ

    更新日期:2020-04-01 00:00:00

  • Immunoglobulin prophylaxis against hepatitis A among Swedish UN soldiers in an endemic region.

    abstract::Six hundred and fifteen Swedish soldiers (X = 24.9 years) serving with the UN forces in Cyprus were tested for antibody against hepatitis A (anti-HAV) before and after six months' service. Before the service, a high susceptibility to hepatitis A was found, as only 2.3% (14/615) had anti-HAV. In comparison, the prevale...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01648930

    authors: Weiland O,Berg JV,Bäck E,Lundbergh P

    更新日期:1979-01-01 00:00:00

  • Hospitalization rates for complicated and uncomplicated chickenpox in a poorly vaccined pediatric population.

    abstract:BACKGROUND:A retrospective study was conducted to provide epidemiological data on hospitalization for complicated and uncomplicated chickenpox in a pediatric population. METHODS:The study analyzed hospitalization cases for chickenpox, among all the 31 Tuscan hospitals, during the period 1997-2003. RESULTS:Globally, 6...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-007-6248-z

    authors: Bonsignori F,Chiappini E,Frenos S,Peraldo M,Galli L,de Martino M

    更新日期:2007-12-01 00:00:00

  • Aortic thrombus and multiple embolisms during a Mycoplasma pneumoniae infection.

    abstract::We report the case of a patient who presented with a thrombus of the aortic arch complicated with splenic, renal and peroneal artery embolisms, associated with transient lupus anticoagulant, during a Mycoplasma pneumoniae infection. The outcome was good under antibiotic and anticoagulant treatment. We also review the ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0475-2

    authors: Flateau C,Asfalou I,Deman AL,Ficko C,Andriamanantena D,Fontan E,Viant E,Bonnevie L,Rapp C

    更新日期:2013-08-01 00:00:00

  • Effective treatment of urinary tract infections.

    abstract::In prescribing any particular antimicrobial agent for the treatment of urinary tract infection decisions have to be made on the choice of drug, on the basis of bacteriological findings, the dosage and the duration of administration. These problems are reviewed below in conjunction with the criteria of successful thera...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644939

    authors: Acar JF

    更新日期:1980-01-01 00:00:00

  • Andrologic studies and sexual potency in chronic human brucellosis.

    abstract::A 100 male patients aged from 20 to 45 years were treated for chronic brucellosis. Sixty-eight complained of impaired sexual potency. The percentage of patients with sexual disorders increased parallel to the duration of the disease. Andrologic investigations comprised a study sexual history, physical examination of t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641469

    authors: Kassur B,Dziubek Z

    更新日期:1980-01-01 00:00:00

  • Studies on serum and cerebrospinal fluid levels of cephacetrile in neonates.

    abstract::The serum half-life of cephacetrile and its penetration from the serum into the cerebrospinal fluid (CSF) was determined in 33 premature and full-term neonates. On an average the serum half-life was 3.6 hours in children with a birth weight above 1,500 g; in children with a birth weight below 1,500 g it was 5.1 hours....

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640789

    authors: Windorfer A,Gasteiger U

    更新日期:1977-01-01 00:00:00

  • Peripheral oxygen availability within skeletal muscle in sepsis and septic shock: comparison to limited infection and cardiogenic shock.

    abstract::In 40 intensive care patients, tissue oxygen partial pressure distribution within skeletal muscle was measured in order to estimate peripheral oxygen availability. In septic patients with multiple organ failure (n = 20) mean skeletal muscle pO2 was abnormally high (48.8 +/- 8.5 mmHg, p less than 0.001) in contrast to ...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01645355

    authors: Boekstegers P,Weidenhöfer S,Pilz G,Werdan K

    更新日期:1991-09-01 00:00:00

  • IFN-alpha: therapeutic options in HIV and HIV/HCV, HIV/HBV dual infection.

    abstract::The antiviral effects of interferon-alpha (IFN-alpha) are well documented for the treatment of hepatitis B or C infections, whereas antiretroviral effects for treatment of HIV-1 infection have been investigated up to now only in small-sized preclinical studies. New preclinical and clinical data on IFN-alpha for HIV, H...

    journal_title:Infection

    pub_type:

    doi:

    authors: Jablonowski H

    更新日期:2003-03-01 00:00:00

  • Transintestinal elimination of ciprofloxacin in humans--concomitant assessment of its metabolites in serum, ileum and colon.

    abstract::Ciprofloxacin (200 mg) was infused to seven patients at the beginning of elective colorectal surgery. Thirty minutes after the end of infusion (i.e. 60 min after the start of the operation) ciprofloxacin reached concentrations of 1.60 mg/l in serum and of 3.42-6.07 mg/kg fresh weight in the ileum and colon. During the...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01710676

    authors: Viell B,Krause B,Vestweber KH,Schaaf S,Scholl H

    更新日期:1992-11-01 00:00:00

  • Neglected tropical diseases in Europe: rare diseases and orphan drugs?

    abstract::Neglected tropical diseases are becoming more and more frequent in Europe due to the increasing immigration from endemic areas. Nonetheless specific treatments are scarcely available in many European countries, since they are neither officially licensed nor marketed. Only a few referral health centres can afford to ac...

    journal_title:Infection

    pub_type: 社论

    doi:10.1007/s15010-018-1241-2

    authors: Calleri G,Angheben A,Albonico M

    更新日期:2019-02-01 00:00:00

  • Serious complications of tuberculous epididymitis.

    abstract::Tuberculous epididymitis is a rare entity associated with minor complications. We present two cases of tuberculous epididymitis associated with serious complications (bilateral psoas abscesses and Addison's disease with psoas abscess). A review of the literature disclosed six additional cases associated with serious c...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s150100050080

    authors: Skoutelis A,Marangos M,Petsas T,Chionis I,Barbalias G,Bassaris H

    更新日期:2000-05-01 00:00:00

  • In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria.

    abstract::The ability of clavulanic acid to inactivate beta-lactamase was investigated using 47 amoxicillin-resistant bacteria. In the presence of 10 mg/l clavulanic acid most strains of staphylococci, Escherichia coli, Klebsiella and Proteus mirabilis became fully amoxicillin-sensitive. This effect of clavulanic acid was in mo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641472

    authors: Peters G,Pulverer G,Neugebauer M

    更新日期:1980-01-01 00:00:00