Abstract:
BACKGROUND:There are conflicting results concerning an association between Chlamydia pneumoniae and MS (multiple sclerosis). In the present study, we investigated a possible therapeutic option with antibiotics. PATIENTS AND METHODS:In our randomized, placebo-controlled double-blind study, 28 patients with the confirmed diagnosis of MS [61% relapsing-remitting MS (RR-MS), 32% secondary chronic-progressive MS (SP-MS) and 7% primary chronic progressive MS (PP-MS)] were treated over a time period of 12 months with three cycles of a 6-week oral antibiotic therapy with roxithromycin (300 mg per day) or placebo. RESULTS:No significant differences were observed in patients with RR-MS regarding the expanded disability status scale (EDSS) and the relapse rate when comparing treatment with roxithromycin and placebo. CONCLUSION:Our study shows that the patients with MS do not profit from a long-term antibiotic treatment with roxithromycin compared to placebo treatment. A causative connection between bacterial infections with C. pneumonia and MS therefore does seem very unlikely.
journal_name
Infectionjournal_title
Infectionauthors
Woessner R,Grauer MT,Frese A,Bethke F,Ginger T,Hans A,Treib Jdoi
10.1007/s15010-006-5114-8subject
Has Abstractpub_date
2006-12-01 00:00:00pages
342-4issue
6eissn
0300-8126issn
1439-0973journal_volume
34pub_type
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