Long-term antibiotic treatment with roxithromycin in patients with multiple sclerosis.

Abstract:

BACKGROUND:There are conflicting results concerning an association between Chlamydia pneumoniae and MS (multiple sclerosis). In the present study, we investigated a possible therapeutic option with antibiotics. PATIENTS AND METHODS:In our randomized, placebo-controlled double-blind study, 28 patients with the confirmed diagnosis of MS [61% relapsing-remitting MS (RR-MS), 32% secondary chronic-progressive MS (SP-MS) and 7% primary chronic progressive MS (PP-MS)] were treated over a time period of 12 months with three cycles of a 6-week oral antibiotic therapy with roxithromycin (300 mg per day) or placebo. RESULTS:No significant differences were observed in patients with RR-MS regarding the expanded disability status scale (EDSS) and the relapse rate when comparing treatment with roxithromycin and placebo. CONCLUSION:Our study shows that the patients with MS do not profit from a long-term antibiotic treatment with roxithromycin compared to placebo treatment. A causative connection between bacterial infections with C. pneumonia and MS therefore does seem very unlikely.

journal_name

Infection

journal_title

Infection

authors

Woessner R,Grauer MT,Frese A,Bethke F,Ginger T,Hans A,Treib J

doi

10.1007/s15010-006-5114-8

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

342-4

issue

6

eissn

0300-8126

issn

1439-0973

journal_volume

34

pub_type

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    authors: Origüen J,Fernández-Ruiz M,Lumbreras C,Orellana MÁ,López-Medrano F,Ruiz-Merlo T,San Juan R,García-Reyne A,González E,Polanco N,Paz-Artal E,Andrés A,Aguado JM

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    doi:10.1007/BF01643233

    authors: Enzensberger R,Braun W,July C,Helm EB,Doerr HW

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    abstract::Turicella otitidis and Corynebacterium auris, described as new species 20 years ago, have been isolated mainly from the external ear canal and middle ear fluid. While their taxonomic position has been clearly established, their diagnosis in the routine laboratory is difficult. The question of their pathogenic potentia...

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    journal_title:Infection

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    doi:10.1007/s150100050070

    authors: Linde H,Glück T,Metz M,Reng C,Erlmeier S,Lehn N

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    pub_type: 历史文章,杂志文章

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    pub_type: 杂志文章

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    authors: Smids C,Kouijzer IJ,Vos FJ,Sprong T,Hosman AJ,de Rooy JW,Aarntzen EH,de Geus-Oei LF,Oyen WJ,Bleeker-Rovers CP

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    doi:10.1007/s15010-009-9069-4

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    pub_type: 杂志文章

    doi:10.1007/BF01648930

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    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s15010-007-7043-6

    authors: Ott SR,Allewelt M,Lorenz J,Reimnitz P,Lode H,German Lung Abscess Study Group.

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  • [Microbiological diagnosis of septicemia].

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    pub_type: 杂志文章

    doi:10.1007/BF01639113

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    pub_type: 杂志文章

    doi:10.1007/BF01643241

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    pub_type: 杂志文章

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    authors: Wenzler-Röttele S,Dettenkofer M,Schmidt-Eisenlohr E,Gregersen A,Schulte-Mönting J,Tvede M

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    journal_title:Infection

    pub_type: 杂志文章

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    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-017-0997-0

    authors: Lehmann C,Berner R,Bogner JR,Cornely OA,de With K,Herold S,Kern WV,Lemmen S,Pletz MW,Ruf B,Salzberger B,Stellbrink HJ,Suttorp N,Ullmann AJ,Fätkenheuer G,Jung N

    更新日期:2017-06-01 00:00:00

  • Pharmacokinetics of imipenem in patients undergoing major colon surgery.

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01646409

    authors: Erttmann M,Krausse R,Ullmann U

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  • Diagnostic accuracy of urinary dipstick to exclude catheter-associated urinary tract infection in ICU patients: a reappraisal.

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    doi:10.1007/s15010-014-0612-6

    authors: Coman T,Troché G,Semoun O,Pangon B,Mignon F,Jacq G,Merceron S,Abbosh N,Laurent V,Guezennec P,Henry-Lagarrigue M,Revault-d'Allonnes L,Ben-Mokhtar H,Audibert J,Bruneel F,Resche-Rigon M,Bedos JP,Legriel S

    更新日期:2014-08-01 00:00:00

  • Epidemiology and clinical impact of glycopeptide resistance in Staphylococcus aureus.

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    pub_type: 杂志文章,评审

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    authors: Ruef C

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    pub_type: 杂志文章,评审

    doi:10.1007/BF01726464

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    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01667215

    authors: Naber KG,Sörgel F,Gutzler F,Bartosik-Wich B

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    pub_type: 杂志文章,多中心研究

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    doi:10.1007/BF01641080

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    更新日期:1983-03-01 00:00:00

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    pub_type: 杂志文章,评审

    doi:

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    更新日期:2003-12-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/BF01704358

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    更新日期:1992-01-01 00:00:00

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    authors: Kourbeti IS,Alegakis DE,Roditakis GE,Samonis G

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