Moxifloxacin vs ampicillin/sulbactam in aspiration pneumonia and primary lung abscess.

Abstract:

BACKGROUND:Aspiration pneumonia (AP) and primary lung abscess (PLA), are diseases following aspiration of infectious material from the oropharynx or stomach. An antibiotic therapy, also covering anaerobic pathogens, is the treatment of choice. In this study we compared moxifloxacin (MXF) and ampicillin/sulbactam (AMP/SUL) concerning efficacy and safety in the treatment of AP and PLA. METHODS:Patients with pulmonary infections following aspiration were included in a prospective, open-label, randomized, multicenter trial. Sequential antibiotic therapy with MXF or AMP/SUL was administered until complete radiologic and clinical resolution. RESULTS:A total of 139 patients with AP and PLA were included, 96 were evaluable for efficacy (EE, 48 patients in each treatment group). The overall clinical response rates in both groups were numerically identical (66.7%). MXF and AMP/SUL were both well tolerated, even after long-term administration [median duration of treatment (range) in days MXF versus AMP/SUL: AP 11 (4-45) vs 9 (3-25), PLA 30.5 (7-158) vs 35 (6-90)]. CONCLUSION:In the treatment of aspiration-associated pulmonary infections moxifloxacin appears to be clinically as effective and as safe as ampicillin/sulbactam; but, however, having the additional benefit of a more convenient (400 mg qd) treatment.

journal_name

Infection

journal_title

Infection

authors

Ott SR,Allewelt M,Lorenz J,Reimnitz P,Lode H,German Lung Abscess Study Group.

doi

10.1007/s15010-007-7043-6

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

23-30

issue

1

eissn

0300-8126

issn

1439-0973

journal_volume

36

pub_type

杂志文章,多中心研究,随机对照试验
  • In vitro-activity of clavulanic acid and amoxicillin combined against amoxicillin-resistant bacteria.

    abstract::The ability of clavulanic acid to inactivate beta-lactamase was investigated using 47 amoxicillin-resistant bacteria. In the presence of 10 mg/l clavulanic acid most strains of staphylococci, Escherichia coli, Klebsiella and Proteus mirabilis became fully amoxicillin-sensitive. This effect of clavulanic acid was in mo...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641472

    authors: Peters G,Pulverer G,Neugebauer M

    更新日期:1980-01-01 00:00:00

  • First report of chronic implant-related septic arthritis and osteomyelitis due to Kytococcus schroeteri and a review of human K. schroeteri infections.

    abstract::We report the first case of Kytococcus schroeteri implant-related septic arthritis and osteomyelitis, identified by phenotypic tests and 16S rRNA sequencing, which responded to implant removal and doxycycline. 16S rRNA sequencing was useful for the accurate and rapid identification of the organism as it exhibited thre...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0250-9

    authors: Chan JF,Wong SS,Leung SS,Fan RY,Ngan AH,To KK,Lau SK,Yuen KY,Woo PC

    更新日期:2012-10-01 00:00:00

  • Efficacy and effects on pulmonary function tests of weekly 600 mg aerosol pentamidine as prophylaxis against Pneumocystis carinii pneumonia.

    abstract::A prospective study was designed to evaluate the efficacy and effects on pulmonary function tests of weekly 600 mg aerosolised pentamidine as prophylaxis against Pneumocystis carinii pneumonia (PCP) amongst two groups of patients infected with the human immunodeficiency virus. Group 1 (primary prophylaxis) consisted o...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01704600

    authors: Ong EL,Dunbar EM,Mandal BK

    更新日期:1992-05-01 00:00:00

  • In vitro activity of new cephalosporins against multi-resistant gram-negative bacteria.

    abstract::The in vitro sensitivities of 47 multi-resistant gram-negative bacilli against six third generation cephalosporins were investigated. Overall, moxalactam was the most active compound and cefoperazone the least active. Ceftizoxime and ceftazidime were very active against Enterobacteriaceae. Ceftriaxone and ceftizoxime ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641100

    authors: Fainstein V,Le Blanc B,Bodey GP

    更新日期:1983-01-01 00:00:00

  • [Use and risk of antibacterial chemotherapy from the medical point of view].

    abstract::The evaluation of the efficacy and possible intolerance of an antibacterial chemotherapy is based on the exact analysis of patient specific signs and symptoms, pathogenetic factors of the specific bacteria and parameters of the specific substance. One has to differentiate between usefulness of the antibiotics (effect)...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01644740

    authors: Lode H

    更新日期:1991-01-01 00:00:00

  • Recommendations for the management of acute hepatitis B: position paper of the Italian Society for the Study of Infectious and Tropical Diseases (SIMIT).

    abstract:PURPOSE:To develop recommendations for the management of acute hepatitis B by the Italian Society for the Study of Infectious and Tropical Diseases. METHODS:Development of the recommendations divided into three levels of evidence according to the GRADE system: A (high), B (medium) and C (low experts opinion), together...

    journal_title:Infection

    pub_type: 杂志文章,实务指引,评审

    doi:10.1007/s15010-014-0642-0

    authors: Bruno R,Carosi G,Coppola N,Gaeta GB,Puoti M,Santantonio T,Taliani G,Armignacco O,Sagnelli E,Andreoni M,Angarano G,Di Perri G,D'Offizi G,Galli M,Rizzardini G,Italian Society for the Study of Infectious and Tropical Diseases.

    更新日期:2014-10-01 00:00:00

  • Hepatitis agents with enteric transmission--an epidemiological analysis.

    abstract:BACKGROUND:Viral hepatitis is characterized by special clinical, biochemical and serological findings. This study was planned to determine the seroprevalence, epidemiological characteristics and clinical and biochemical findings of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections during an outbreak of jau...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2123-0

    authors: Yayli G,Kiliç S,Ormeci AR

    更新日期:2002-12-01 00:00:00

  • Management of a Mycobacterium immunogenum infection of a peritoneal dialysis catheter site.

    abstract::Mycobacterium immunogenum is a member of the rapidly growing non-tuberculous mycobacteria and is a relatively new species identified within this group. An 81-year-old immune-competent male was diagnosed with M. immunogenum infection of his peritoneal dialysis catheter exit site and surrounding soft tissue. To our know...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-018-1199-0

    authors: Shenoy A,El-Nahal W,Walker M,Chopra T,Townsend G,Heysell S,Eby J

    更新日期:2018-12-01 00:00:00

  • Guillain-Barré syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c.

    abstract::In this report, we present a case of a 50-year-old immunocompetent man with Guillain-Barré syndrome (GBS) associated with an autochthonous hepatitis E virus (HEV) infection. The patient presented with tetraparesis and elevated liver enzymes. HEV infection was confirmed serologically and by polymerase chain reaction (P...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-013-0448-5

    authors: Scharn N,Ganzenmueller T,Wenzel JJ,Dengler R,Heim A,Wegner F

    更新日期:2014-02-01 00:00:00

  • Ampicillin concentrations in middle ear effusions in acute otitis media after administration of bacampicillin.

    abstract::The penetration of ampicillin into middle ear effusions after oral administration of 800 mg bacampicillin to patients with acute otitis media was studied and compared with the serum levels. One hour after administration a mean (+/- SEM) concentration of 2.4 +/- 0.4 micrograms/ml ampicillin was found in the effusions a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01659775

    authors: Virtanen S,Lahikainen EA

    更新日期:1979-01-01 00:00:00

  • [Altered bacterial periurethral flora in young girls with chronic, recurrent urinary tract infections? (author's transl)].

    abstract::Assuming a local weakness in the defence system to be responsible for chronic, recurrent infection of the urinary tract in young girls, we made 86 determinations of the bacterial periurethral flora from 70 female patients aged between five and eleven years. Within three patient groups (urologically healthy, temporaril...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640729

    authors: Hofmann K,Marget W,Belohradsky B

    更新日期:1981-01-01 00:00:00

  • Cerebrospinal fluid glucose levels and sensorineural hearing loss in bacterial meningitis.

    abstract:BACKGROUND:Low cerebrospinal fluid (CSF) glucose levels have been associated with sensorineural hearing loss (SNHL) in bacterial meningitis but systematic investigations are lacking. PATIENTS AND METHODS:A retrospective case control study was conducted comparing CSF glucose levels in 47 cases with and 145 controls wit...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-003-3208-0

    authors: Eisenhut M,Meehan T,Batchelor L

    更新日期:2003-08-01 00:00:00

  • Serum immunoglobulin levels in hepatitis non-A, non-B: a comparison with hepatitis A and B.

    abstract::The serum levels of IgA, IgG and IgM were determined by the single radial immunodiffusion method in 86 patients with acute viral hepatitis serologically differentiated by radioimmunoassays. The levels of IgA and IgG were similar in patients with hepatitis A, B and non-A, non-B, while differences in IgM levels were obs...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01641470

    authors: Norkrans G,Nilsson LA,Frösner G,Wahl M,Iwarson S

    更新日期:1980-01-01 00:00:00

  • The effects of pretransplant conditioning, graft-versus-host disease and sepsis on the CRP levels in bone marrow transplantation.

    abstract::To evaluate the diagnostic utility of C-reactive protein (CRP) for the detection of sepsis in bone marrow transplantation, CRP levels were analyzed after pretransplant conditioning and variably combined in septic, focal or viral infections with graft-versus-host disease (GvHD) in 64 bone marrow recipients. The CRP lev...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01740812

    authors: Rintala E,Remes K,Salmi TT,Koskinen P,Nikoskelainen J

    更新日期:1997-11-01 00:00:00

  • Experiences on the efficacy and safety of nalidixic acid, oxolinic acid, cinoxacin and norfloxacin in the treatment of urinary tract infections (UTI).

    abstract::The purpose of this study was to determine the effectiveness and tolerability of norfloxacin, cinoxacin and oxolinic acid in the treatment of urinary tract infections (UTI) in comparison to nalidixic acid. 125 patients were given the drugs in the appropriate doses for 10-14 days and 30 patients were treated for six we...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01645218

    authors: Sabbour MS,El Bokl MA,Osman LM

    更新日期:1984-11-01 00:00:00

  • In-vitro susceptibility of cefoperazone-susceptible and -resistant gram-negative rods to cefoperazone plus sulbactam, other beta-lactams, aminoglycosides and quinolone.

    abstract::We compared the in-vitro activity of cefoperazone-sulbactam (2:1), other beta-lactams, amino-glycosides and ciprofloxacin against cefoperazone-susceptible and -resistant nosocomial gram-negative bacilli. Resistant isolates including Pseudomonas aeruginosa were susceptible to cefoperazone-sulbactam; the susceptible iso...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643761

    authors: Chandrasekar PH,Sluchak JA

    更新日期:1991-01-01 00:00:00

  • Were all carbapenemases created equal? Treatment of NDM-producing extensively drug-resistant Enterobacteriaceae: a case report and literature review.

    abstract:PURPOSE:There is currently a paucity of published literature focused on the treatment of infections caused by NDM-producing organisms. METHODS:We describe a case of a bacteraemia caused by an extensively drug-resistant (XDR) New Delhi metallo-β-lactamase (NDM)-producing Serratia marcescens and review the treatment opt...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-017-1070-8

    authors: Chibabhai V,Nana T,Bosman N,Thomas T,Lowman W

    更新日期:2018-02-01 00:00:00

  • Subcutaneous abscess due to the basidiomycete Phellinus mori in a patient with chronic granulomatous disease.

    abstract::Chronic granulomatous disease (CGD), a primary immunodeficiency caused by impaired phagocyte killing of intracellular pathogens, is characterized by recurrent, life-threatening, bacterial and fungal infections. As a result of improvements in microbiologic culture and identification techniques, a number of unique filam...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0724-7

    authors: Shigemura T,Nakazawa Y,Amano Y,Sudo A,Watanabe M,Kobayashi M,Kobayashi N,Koike K,Agematsu K,Nishimura K

    更新日期:2015-06-01 00:00:00

  • ELISA for antibodies to lipid A, lipopolysaccharides and other hydrophobic antigens.

    abstract::A simple, sensitive and rapid ELISA method for the quantification and characterization of antibodies to lipid A has been developed, which can also be applied to other hydrophobic antigens. For coating, antigens were applied to the wells of ELISA plates as solutions in a mixture of chloroform and ethanol 1:9 (v/v), and...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01650719

    authors: Freudenberg MA,Fomsgaard A,Mitov I,Galanos C

    更新日期:1989-09-01 00:00:00

  • Treatment of recurrent Clostridium difficile infection: a systematic review.

    abstract:BACKGROUND:Clostridium difficile infection (CDI) recurs in nearly one-third of patients who develop an initial infection. Recurrent CDI (RCDI) is associated with considerable morbidity, mortality, and cost. Treatment for RCDI has not been not well examined. METHODS:A systematic review. RESULTS:Sixty-four articles wer...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-013-0496-x

    authors: O'Horo JC,Jindai K,Kunzer B,Safdar N

    更新日期:2014-02-01 00:00:00

  • Localized pulmonary infection associated with Mycobacterium tilburgii in an HIV-infected patient.

    abstract::The case of an HIV-infected patient with low CD4+ cell count and localized pulmonary infection associated with Mycobacterium tilburgii, a recently recognized atypical mycobacterial species, is reported. Diagnosis was confirmed by repeated detection of mycobacterial DNA in lung biopsy specimens. After surgical removal ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-4118-0

    authors: Kolditz M,Halank M,Spornraft-Ragaller P,Schmidt H,Höffken G

    更新日期:2005-08-01 00:00:00

  • In vitro susceptibility of anaerobes to co-trimoxazole.

    abstract::The minimal inhibitory concentrations (MIC) of sulfamethoxazole and trimethoprim against 144 strains of obligately anaerobic bacteria were determined on supplemented Diagnostic Sensitivity Test (Oxoid) agar or broth. 58% of the strains were susceptible to sulfamethoxazole alone (MIC less than or equal to 16 micrograms...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639889

    authors: Wüst J

    更新日期:1980-01-01 00:00:00

  • Interobserver agreement on signs and symptoms of patients with acute febrile illness.

    abstract:PURPOSE:To assess the interobserver agreement on clinical history and physical examination when using a semi-structured questionnaire to evaluate patients with an acute febrile illness (AFI). METHODS:A cross-sectional study was conducted with outpatients aged 12 years and over, presenting with an AFI defined as fever ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-011-0101-0

    authors: Daumas RP,Brasil P,Bressan CS,Oliveira RV,Carvalho BB,Carneiro DV,Passos SR

    更新日期:2011-04-01 00:00:00

  • The epidemiological burden and overall distribution of chronic comorbidities in coronavirus disease-2019 among 202,005 infected patients: evidence from a systematic review and meta-analysis.

    abstract:PURPOSE:The main purpose of this study was to examine the overall distribution of chronic comorbidities in coronavirus disease-19 (COVID-19) infected populations and the risk of the underlying burden of disease in terms of the case fatality ratio (CFR). METHODS:We carried out a systematic review and meta-analysis of s...

    journal_title:Infection

    pub_type: 杂志文章,meta分析

    doi:10.1007/s15010-020-01502-8

    authors: Mahumud RA,Kamara JK,Renzaho AMN

    更新日期:2020-12-01 00:00:00

  • Clinical evaluation of the antifungal effect of sertraline in the treatment of cryptococcal meningitis in HIV patients: a single Mexican center experience.

    abstract:PURPOSE:Cryptococcal meningitis is a potentially fatal fungal infection associated with a significant attributable morbidity and mortality, especially among HIV/AIDS patients. The first-line therapy for the treatment of this clinical entity is the combinatory therapy of amphotericin B plus flucytosine. However, the hig...

    journal_title:Infection

    pub_type: 杂志文章,随机对照试验

    doi:10.1007/s15010-017-1059-3

    authors: Villanueva-Lozano H,Treviño-Rangel RJ,González GM,Hernández-Rodríguez PA,Camacho-Ortiz A,Castillo-Reyna L,Galindo-Alvarado SG,Martínez-Reséndez MF

    更新日期:2018-02-01 00:00:00

  • Surgical site infection: rates, etiology and resistance patterns to antimicrobials among strains isolated at Rio de Janeiro University Hospital.

    abstract::A 6-month prospective surveillance was conducted in the Department of General Surgery of the Rio de Janeiro University Hospital. Postoperative infections were classified according to CDC criteria. This study reports a significant rate (16.9%) in surgical infections detected by surveillance in a series where 45% of sur...

    journal_title:Infection

    pub_type: 临床试验,杂志文章

    doi:10.1007/BF01713147

    authors: Santos KR,Fonseca LS,Bravo Neto GP,Gontijo Filho PP

    更新日期:1997-07-01 00:00:00

  • Mortality risk factors with nosocomial Staphylococcus aureus infections in intensive care units: results from the German Nosocomial Infection Surveillance System (KISS).

    abstract:INTRODUCTION:As the number of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infections in German intensive care units increases, the problem of MRSA infection as such is becoming ever more serious. The aim of this study was to investigate whether mortality rates from nosocomial MRSA pneumonia and primar...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-005-3186-5

    authors: Gastmeier P,Sohr D,Geffers C,Behnke M,Daschner F,Rüden H

    更新日期:2005-04-01 00:00:00

  • Duration of posaconazole therapy for Aspergillus fumigatus osteomyelitis dictated by serial monitoring of 1,3-beta-D glucan.

    abstract::Here, we present a case of an immunocompetent 37-year old male who developed Aspergillus fumigatus osteomyelitis 16 years after extensive chest wall reconstructive surgery for Ewing sarcoma. His treatment course was complicated by a severe adverse drug reaction to voriconazole, requiring the use of oral posaconazole t...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-020-01489-2

    authors: Doub JB,Mathur P

    更新日期:2020-12-01 00:00:00

  • Rotavirus epidemiology and vaccine demand: considering Bangladesh chapter through the book of global disease burden.

    abstract:BACKGROUND:Rotavirus is the major cause of gastroenteritis in children throughout the world. Every year, a large number of children aged < 5 years die from rotavirus-related diarrhoeal diseases. Though these infections are vaccine-preventable, the vast majority of children in low-income countries suffer from the infect...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-017-1082-4

    authors: Mahmud-Al-Rafat A,Muktadir A,Muktadir H,Karim M,Maheshwari A,Ahasan MM

    更新日期:2018-02-01 00:00:00

  • Treatment of Lyme arthritis.

    abstract::The efficacy of different therapeutic regimens for Lyme arthritis is reviewed. The first treatment for Lyme arthritis, intramuscular benzathine penicillin 2.4 million units weekly for 3 weeks, had a success rate of 35%. Another study employed intravenous penicillin G at a dosage of 20 million units daily for 10 days, ...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01780668

    authors: Cimmino MA,Moggiana GL,Parisi M,Accardo S

    更新日期:1996-01-01 00:00:00