Abstract:
:The penetration of ampicillin into middle ear effusions after oral administration of 800 mg bacampicillin to patients with acute otitis media was studied and compared with the serum levels. One hour after administration a mean (+/- SEM) concentration of 2.4 +/- 0.4 micrograms/ml ampicillin was found in the effusions and the mean serum level was 7.7 +/- 0.8 micrograms/ml. After twelve hours a mean concentration of 0.6 +/- 0.2 micrograms/ml was found in the middle ear effusions and 0.1 +/- 0.03 micrograms/ml in the serum. The high concentration of ampicillin in middle ear effusions after twelve hours suggests that a twice daily dosage of bacampicillin should be given in acute otitis media.
journal_name
Infectionjournal_title
Infectionauthors
Virtanen S,Lahikainen EAdoi
10.1007/BF01659775subject
Has Abstractpub_date
1979-01-01 00:00:00pages
S472-4eissn
0300-8126issn
1439-0973journal_volume
7 Suppl 5pub_type
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