Abstract:
BACKGROUND:Catheter-associated urinary tract infection is the most common nosocomial infection in clinical settings. For bacteria ascending to the bladder the most common route is the extraluminal, but the intraluminal route also plays a role. For this reason, we compared two urinary closed system bags (CSB), one with a double and the other with a single non-return valve (NRV), in a laboratory setting in order to establish their ability to prevent or delay the ascent of bacteria from the drainage bag to the bladder. PATIENTS AND METHODS:The tests were performed in two microbiological laboratories (Copenhagen (C), Denmark and Freiburg (F), Germany). These were blinded to each other. A urinary tract model using artificial urine was set up. Two sets of ten drainage bags each with a double NRV (CSB A), and two sets of ten drainage bags each with a single NRV (CSB B) were inoculated with Escherichia coli (F: ATCC 25922; C: clinical strain). Daily samples were taken from two drainage ports on each system - one above the NRV (Port I), the other above the top of the artificial bladder (Port II). Time till E. coli was detected at the drainage ports (time to positivity) was measured. Colonization of the 'bladder' was defined as time to positivity at Port II. RESULTS:No significant differences in time to positivity at Port I (median 9.0, range: 6-12 for CSB B vs median 9.5 days, range: 6-13 for CSB A) were observed between the two systems. However, substantial differences were seen between the two systems in time to positivity at Port II: Port II on the bladder model using CSB B became positive after a median of 14.0 days (range: 10-22), whereas Port II of the model using CSB A only became positive after 21.5 days (range: 13-24). This amounts to a highly significant difference of 7.5 days (p = 0.0001) in the mean. CONCLUSION:Under laboratory conditions, colonization of the 'bladder' was significantly delayed when the CSB with a double NRV was used in comparison to the results obtained from the single NRV-system. Clinical trials should be conducted to investigate whether the urinary CSB with the double NRV has the ability to prevent (or to delay the onset of) catheter-associated urinary tract infection.
journal_name
Infectionjournal_title
Infectionauthors
Wenzler-Röttele S,Dettenkofer M,Schmidt-Eisenlohr E,Gregersen A,Schulte-Mönting J,Tvede Mdoi
10.1007/s15010-006-5626-2subject
Has Abstractpub_date
2006-08-01 00:00:00pages
214-8issue
4eissn
0300-8126issn
1439-0973journal_volume
34pub_type
杂志文章相关文献
INFECTION文献大全abstract::Polymorphonuclear leukocyte (PMNL) chemotaxis was evaluated in ten healthy volunteers who had received 600 mg of clindamycin intramuscularly. Serum obtained 3 hours after the administration of clindamycin significantly increased PMNL chemotaxis. Serum obtained at 12 and 24 hours after the administration of the drug di...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01712455
更新日期:1993-09-01 00:00:00
abstract::The kinetics of human cytomegalovirus (HCMV)-specific immunoglobulin E (IgE), M (IgM), A (IgA) and G (IgG) were studied in 421 sera obtained from 19 renal allograft recipients by enzyme-linked immunosorbent assay (ELISA). Cytomegalic inclusion disease (CID) occurred in 11 (57.9%) patients. HCMV infection was diagnosed...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01710536
更新日期:1993-05-01 00:00:00
abstract::During the course of chronic hepatitis B virus (HBV) infection, a patient seropositive for hepatitis B e antigen experienced four episodes of acute hepatic necroinflammation. Serum HBV-DNA concentration elevated immediately before the first and third exacerbations, whereas serum hepatitis C virus (HCV) RNA was detecte...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-001-1195-6
更新日期:2001-12-01 00:00:00
abstract:PURPOSE:To describe the demographic, clinical, and microbiological profile of native vertebral osteomyelitis (NVO) in aged patients as compared to that of younger patients, to identify differences that could motivate changes in clinical management. METHODS:Retrospective, observational cohort study (1990-2015) includin...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1177-6
更新日期:2018-10-01 00:00:00
abstract::A 200 mg oral dose of ciprofloxacin, norfloxacin or ofloxacin was administered to six healthy male volunteers in a three way cross-over study in order to examine the kinetics in humans in relation to the bactericidal activity in serum and urine. Serum concentrations for ciprofloxacin were similar to norfloxacin and lo...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01650502
更新日期:1988-01-01 00:00:00
abstract::The most efficient route of transmission of hepatitis C virus (HCV) infection is through contaminated blood. Sexual transmission or other close human contact could play a role in sporadic infections. We describe a case of acute hepatitis C progressing to chronic hepatitis over a follow-up of 4 years in a 44-year-old w...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s15010-007-6188-7
更新日期:2007-12-01 00:00:00
abstract::Penetration of ciprofloxacin into human tonsils was studied following an intravenous infusion of 200 mg over 15 minutes to adult humans undergoing tonsillectomy. Samples were taken one-and-a-half to four hours after dosing. Generally, tissue levels exceeded corresponding serum concentrations by 50% (range of intraindi...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01651152
更新日期:1984-09-01 00:00:00
abstract::Using the immunofluorescence technique in 187 patients with bacteriologically proven prostatitis according to the Meares-Stamey test demonstrated a significant amount of antibody-coated bacteria (ACB) in their ejaculates. The ACB test was useful to discriminate between chronic bacterial prostatitis and prostatodynia w...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643684
更新日期:1991-01-01 00:00:00
abstract:PURPOSE:The incidence of Staphylococcus aureus skin and soft tissue infection (SSTI) is high in sub-Saharan Africa. This is fueled by a high prevalence of Panton-Valentine leukocidin (PVL), which can be associated with necrotizing disease. The aim was to describe the clinical presentation and the treatment of SSTI in t...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-018-1140-6
更新日期:2018-06-01 00:00:00
abstract::Ciprofloxacin (200 mg) was infused to seven patients at the beginning of elective colorectal surgery. Thirty minutes after the end of infusion (i.e. 60 min after the start of the operation) ciprofloxacin reached concentrations of 1.60 mg/l in serum and of 3.42-6.07 mg/kg fresh weight in the ileum and colon. During the...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01710676
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Screening for staphylococci among various patient populations has become important for appropriate therapeutic management and for control of nosocomial infections. The purpose of this study is to evaluate the in vitro sensitivity and specificity of a chromogenic agar medium, S. aureus ID (bioMérieux, France)...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-006-5094-8
更新日期:2006-04-01 00:00:00
abstract:BACKGROUND:There is very less information on the use of antiretroviral (ARV) drugs and viro-immunological outcome over calendar years in Italy. PATIENTS AND METHODS:We performed an analysis of a prospective observational cohort (MASTER) to assess antiretroviral drug use in first line HAART and explore whether initial ...
journal_title:Infection
pub_type: 杂志文章,多中心研究
doi:10.1007/s15010-007-7227-0
更新日期:2008-06-01 00:00:00
abstract:PURPOSE:Since May 2016, WHO recommended a 9-12 month short-treatment regimen for multidrug-resistant tuberculosis (MDR-TB) treatment known as the 'Bangladesh Regimen'. However, limited data exist on the appropriateness thereof, and its implementation in low- and middle-income countries (LMIC). We report here on the pil...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-019-01314-5
更新日期:2019-10-01 00:00:00
abstract::Drug-induced anaphylaxis is an unpredictable adverse reaction. Although it may occur with any medication, antibiotics induce more cases of anaphylaxis than any other medication class with most cases being induced by β-lactam antibiotics. Clindamycin is an antibiotic with good gram-positive and anaerobe coverage which ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-015-0826-2
更新日期:2016-06-01 00:00:00
abstract::Eighty-nine patients with a history of recurrent urinary infection who required immediate treatment for significant bacteriuria were treated with either trimethoprim (300 mg at night) or with the standard course of co-trimoxazole (two tablets 12-hourly) for seven days. Cure rates one week after the end of treatment we...
journal_title:Infection
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1007/BF01640874
更新日期:1982-09-01 00:00:00
abstract:OBJECT:To assess easily monitored predictors for tuberculosis mortality. DESIGN:Risk factors for tuberculosis mortality were assessed during the 8-month treatment in 440 men and 269 women diagnosed with confirmed or presumed intrathoracic tuberculosis included prospectively in Guinea-Bissau from May 1996 to April 2001...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6090-3
更新日期:2007-04-01 00:00:00
abstract::Cefoperazone, an antibiotic commonly used for prophylaxis of infection, has been associated with hypoprothrombinemia and bleeding. To reduce the risk of bleeding, co-administration of vitamin K has been advised. We reassessed the need for vitamin K use in a retrospective analysis of 50 patients undergoing urologic pro...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01704604
更新日期:1992-05-01 00:00:00
abstract::A 12-year-old girl with a 2-month history of fever and abdominal pain was admitted to our hospital. Ultrasound and CT scans of the abdomen showed multiple hypoechoic lesions of liver and spleen. Screening for zoonosis revealed high positive titers to Bartonella henselae. T-cell deficiency was demonstrated and remained...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/s150100050059
更新日期:2000-03-01 00:00:00
abstract::A microbiological analysis of 102 patients suffering from cystic fibrosis was conducted over a 22 month period. 20 microbial species with the following incidence were identified: Pseudomonas aeruginosa: 83.4%; Candida albicans: 29.4%; Staphylococcus aureus: 24.5%; Staphylococcus epidermidis: 11.8%; Haemophilus influen...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644137
更新日期:1987-07-01 00:00:00
abstract::A 6-month prospective surveillance was conducted in the Department of General Surgery of the Rio de Janeiro University Hospital. Postoperative infections were classified according to CDC criteria. This study reports a significant rate (16.9%) in surgical infections detected by surveillance in a series where 45% of sur...
journal_title:Infection
pub_type: 临床试验,杂志文章
doi:10.1007/BF01713147
更新日期:1997-07-01 00:00:00
abstract:PURPOSE:To evaluate the impact of country socioeconomic status and hospital type on device-associated healthcare-associated infections (DA-HAIs) in neonatal intensive care units (NICUs). METHODS:Data were collected on DA-HAIs from September 2003 to February 2010 on 13,251 patients in 30 NICUs in 15 countries. DA-HAIs ...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0136-2
更新日期:2011-10-01 00:00:00
abstract::The recent literature on clostridial infections of animals and infections due to gram-negative anaerobic rods is reviewed. It is stressed that quite recently the literature is concerned with animal models for the evaluation and study of the chemotherapy, immunity mechanisms and pathogenesis of Fusobacterium and Bacter...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF01639869
更新日期:1980-01-01 00:00:00
abstract::The incidence of fulminant hepatitis in Taiwan was studied in a series of consecutive 523 patients with acute viral hepatitis including 11 with acute hepatitis A, 67 with acute hepatitis B, 124 with acute hepatitis NANB and 321 acute hepatitis in HBsAg carriers (patients who were HBsAg positive but anti-HBc IgM negati...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01643385
更新日期:1990-07-01 00:00:00
abstract::The humoral and cell mediated immune response was investigated in 90 patients suffering from chronic posttraumatic osteomyelitis. In 10-20% of the patients the serum IgG and IgM was increased, in 5-10% the levels were decreased. The values were compared with those of a control group of 35 normal healthy volunteers. Of...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01638722
更新日期:1976-01-01 00:00:00
abstract:PURPOSE:Bloodstream infections (BSIs) are frequent after allogeneic haematopoietic stem cell transplantation (HSCT). The aim of this study was to identify predictors of mortality after BSI in patients who undergo HSCT. METHODS:Patients who underwent HSCT between 1 January 2004 and 31 January 2008 and developed BSI dur...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0229-y
更新日期:2012-06-01 00:00:00
abstract::Haemolytic uraemic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP) are thrombotic microangiopathies increasingly reported in patients with HIV infection. However, characteristic features of thrombotic microangiopathies associated with HIV disease have not been defined yet. The typical courses of HUS and T...
journal_title:Infection
pub_type: 杂志文章,评审
doi:10.1007/BF02565164
更新日期:1999-01-01 00:00:00
abstract::In prescribing any particular antimicrobial agent for the treatment of urinary tract infection decisions have to be made on the choice of drug, on the basis of bacteriological findings, the dosage and the duration of administration. These problems are reviewed below in conjunction with the criteria of successful thera...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/BF01644939
更新日期:1980-01-01 00:00:00
abstract:PURPOSE:Limited data are available on immunologic responses to primary pandemic H1N1 (2009) vaccination in recipients of allogeneic hematopoietic stem cell transplantation (HSCT) recipients. In 2009 serologic responses to either pandemic H1N1 (2009) vaccine (n = 36) or pandemic H1N1 (2009) infection (n = 2) were studie...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-011-0206-5
更新日期:2012-04-01 00:00:00
abstract::We describe a 66-year-old woman hospitalized with fever, fatigue and hepatopathy. In her medical history arterial hypertension (treated with propranolol and lisinopril), diabetes mellitus type 2 (no treatment before admission) and a gout arthropathy were noted wherefore a therapy with allopurinol 300 mg per day has be...
journal_title:Infection
pub_type: 杂志文章
doi:10.1007/s15010-007-6365-8
更新日期:2008-08-01 00:00:00
abstract::Neglected tropical diseases are becoming more and more frequent in Europe due to the increasing immigration from endemic areas. Nonetheless specific treatments are scarcely available in many European countries, since they are neither officially licensed nor marketed. Only a few referral health centres can afford to ac...
journal_title:Infection
pub_type: 社论
doi:10.1007/s15010-018-1241-2
更新日期:2019-02-01 00:00:00