Controversies in the therapeutic approach to congenital cytomegalovirus infection.

Abstract:

:Treatment of congenital cytomegalovirus infection is mandatory in cases with severe systemic and/or neurological involvement. However, some patients are paucisymptomatic, with very subtle systemic manifestations and/or minimal brain alterations. Current international guidelines do not clearly state whether these children should be treated, and this decision is not straightforward for clinicians. Of a small series of six infants with congenital cytomegalovirus infection admitted to our neonatal unit between 2015 and 2019, half showed paucisymptomatic neurological manifestations. In these cases, the determination of ß2-microglobulin in cerebrospinal fluid and magnetic resonance imaging aided in the decision-making concerning the therapeutic approach to follow.

journal_name

Infection

journal_title

Infection

authors

Garrido-Barbero M,Arnaez J,Garcia-Alix A

doi

10.1007/s15010-020-01392-w

subject

Has Abstract

pub_date

2020-06-01 00:00:00

pages

463-469

issue

3

eissn

0300-8126

issn

1439-0973

pii

10.1007/s15010-020-01392-w

journal_volume

48

pub_type

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