A standard immunoglobulin preparation produced from bovine colostra shows antibody reactivity and neutralization activity against Shiga-like toxins and EHEC-hemolysin of Escherichia coli O157:H7.

Abstract:

:Enterohemorrhagic Escherichia coli (EHEC) causes a variety of clinical conditions, the most important being hemorrhagic colitis and hemolytic uremic syndrome. A curative therapy of EHEC diseases is not yet feasible. This study investigates the antibody reactivity of Lactobin, a standardized immunoglobulin (Ig) preparation, obtained from the colostra of non-immunized cows. Three different batches of Lactobin exhibited equally high titers of specific antibodies against Shiga-like toxins (SLTs, verocytotoxins) and EHEC hemolysin (EHEC-Hly) produced by E. coli O157. In addition, Lactobin blocked the cytotoxic effect of SLT-I and SLT-II on Vero cell monolayers and inhibited the cytolytic effects of EHEC-Hly on human erythrocytes. Since Lactobin contains high levels of antibodies and neutralizing activity against important virulence factors of EHEC O157, this drug has potential use in the treatment of diarrhea and the prevention of EHEC-associated hemolytic uremic syndrome.

journal_name

Infection

journal_title

Infection

authors

Lissner R,Schmidit H,Karch H

doi

10.1007/BF01716084

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

378-83

issue

5

eissn

0300-8126

issn

1439-0973

journal_volume

24

pub_type

杂志文章
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    更新日期:1992-11-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2006-12-01 00:00:00

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    pub_type: 杂志文章

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    pub_type: 杂志文章

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    更新日期:1988-01-01 00:00:00

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