Abstract:
:GM-CSF is a hemopoietic growth factor with substantial effects on the proliferation of neutrophils, eosinophils and monocytes/macrophages. Its physiologic role in infection is still poorly understood. The gene for GM-CSF is constitutively transcribed in cells substantial for antiinfectious response. Various cells are activated and induced by TNF and IL-1 to synthesize GM-CSF. No systemic GM-CSF levels can be detected in patients with infection. It is likely that GM-CSF plays its physiological role in the immediate vicinity of the cells by which it is secreted. GM-CSF functionally activates neutrophils, monocytes/macrophages and eosinophils. It may augment T-cell proliferation and function. GM-CSF is effective in mice infected with Staphylococcus aureus or Salmonella typhimurium. Its effect in infectious disease in man should be explored.
journal_name
Infectionjournal_title
Infectionauthors
Freund M,Kleine HDdoi
10.1007/BF01705024keywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
S84-92eissn
0300-8126issn
1439-0973journal_volume
20 Suppl 2pub_type
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