The role of GM-CSF in infection.

Abstract:

:GM-CSF is a hemopoietic growth factor with substantial effects on the proliferation of neutrophils, eosinophils and monocytes/macrophages. Its physiologic role in infection is still poorly understood. The gene for GM-CSF is constitutively transcribed in cells substantial for antiinfectious response. Various cells are activated and induced by TNF and IL-1 to synthesize GM-CSF. No systemic GM-CSF levels can be detected in patients with infection. It is likely that GM-CSF plays its physiological role in the immediate vicinity of the cells by which it is secreted. GM-CSF functionally activates neutrophils, monocytes/macrophages and eosinophils. It may augment T-cell proliferation and function. GM-CSF is effective in mice infected with Staphylococcus aureus or Salmonella typhimurium. Its effect in infectious disease in man should be explored.

journal_name

Infection

journal_title

Infection

authors

Freund M,Kleine HD

doi

10.1007/BF01705024

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

S84-92

eissn

0300-8126

issn

1439-0973

journal_volume

20 Suppl 2

pub_type

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    更新日期:1987-07-01 00:00:00

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    doi:10.1007/BF01710747

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    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1007/BF01641306

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