[Parenteral cephalosporins for the treatment of lower respiratory tract infections].

Abstract:

:In most cases of respiratory tract infection, antibiotic therapy has to be initiated before the results of microbiological examination are available. The four most common pathogens of acute exacerbations of chronic bronchitis are pneumococci, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus. Pneumococci are the predominant pathogens of community-acquired pneumonia, followed by H. influenzae and staphylococci. Legionella, mycoplasma and chlamydia vary in frequency according to the population studied. Staphylococci, Pseudomonas, Enterobacter and Klebsiella spp. as well as H. influenzae are the major pathogens of secondary pneumonia. For reasons of cost and environmental problems, oral antibiotics ought to be used whenever possible considering the severity of the infection and patient circumstance. Parenteral antibiotics are indicated in severe infections in order to provide high therapeutic drug levels. Second generation cephalosporins are appropriate for initial therapy of lower respiratory tract infections. In case of severe infection, cephalosporins should be combined with an aminoglycoside, ureidopenicillin or quinolone. Cefuroxime has shown good clinical efficacy and tolerance in lower respiratory tract infections.

journal_name

Infection

journal_title

Infection

authors

Vogel F

doi

10.1007/BF01710341

subject

Has Abstract

pub_date

1993-01-01 00:00:00

pages

S28-34

eissn

0300-8126

issn

1439-0973

journal_volume

21 Suppl 1

pub_type

杂志文章,评审
  • [Enoxacin concentration in bone tissue].

    abstract::For successful treatment of bacterial osteomyelitis the administered antibiotic must reach sufficiently high concentrations in bone tissues. Therefore concentrations of enoxacin in bone in ten patients requiring hip surgery were measured. To prevent a postoperative infection, 400 mg enoxacin b.i.d. for two days were a...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643632

    authors: Adam D,Weismeier K,Sörgel F,Zürcher J

    更新日期:1989-01-01 00:00:00

  • Susceptibility of frequent urinary pathogens to fosfomycin trometamol and eight other antibiotics: results of an Italian multicenter survey.

    abstract::In order to assess the resistance profile for fosfomycin trometamol after several years of clinical use in Italy, this study has explored the susceptibility to fosfomycin and eight other antibacterial drugs of 6,021 strains isolated from 23,816 urines during 1990 in three teaching hospitals located in Genoa, Parma and...

    journal_title:Infection

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1007/BF01710017

    authors: Schito GC,Chezzi C,Nicoletti G,Moreddu M,Arcangeletti MC,Stefani S,Albini E,Del Bono GP

    更新日期:1992-01-01 00:00:00

  • In vitro testing of clarithromycin in combination with ethambutol and rifampicin against Mycobacterium avium complex.

    abstract::The activity of clarithromycin in combination with ethambutol and rifampicin was tested at concentrations achievable in serum against 20 strains of Mycobacterium avium complex. The combination of clarithromycin plus rifampicin showed inhibition of 11 of the strains and bactericidal synergism against seven of the strai...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01645362

    authors: Stauffer F,Dörtbudak O,Lahonik E

    更新日期:1991-09-01 00:00:00

  • Klebsiella brain abscess in adults.

    abstract:BACKGROUND:We analyzed the clinical manifestations and therapeutic outcomes of Klebsiella brain abscesses. PATIENTS AND METHODS:The clinical data of 15 patients with Klebsiella brain abscesses, retrospectively collected over a 14-year period, were studied. RESULTS:The 15 patients included 13 cases of Klebsiella pneum...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-0069-2

    authors: Liliang PC,Lin YC,Su TM,Rau CS,Lu CH,Chang WN,Lee TC,Chen HJ

    更新日期:2001-03-01 00:00:00

  • Twenty-eight cases of Mycobacterium marinum infection: retrospective case series and literature review.

    abstract:PURPOSE:Invasive Mycobacterium marinum disease (tenosynovitis and osteomyelitis) may be an increasingly common manifestation of M. marinum infection that presents unique diagnostic and therapeutic challenges. We conducted a retrospective case series and literature review of M. marinum infection to better understand the...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/s15010-015-0776-8

    authors: Johnson MG,Stout JE

    更新日期:2015-12-01 00:00:00

  • Legionella in two splenectomized patients. Coincidence or causal relationship?

    abstract::We describe two splenectomized patients admitted with pneumonia. The course in one was complicated by overwhelming multiorgan failure when the only indicative laboratory result was seropositivity for Legionella hackeliae and Legionella longbeachae. He was initially treated with ceftriaxone and roxithromycin, followed ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-3005-4

    authors: Gorelik O,Lazarovich Z,Boldur I,Almoznino-Sarafian D,Alon I,Modai D,Cohen N

    更新日期:2004-06-01 00:00:00

  • [Bone concentrations of imipenem after a dose of imipenem/cilastatin].

    abstract::The concentration of imipenem in organic bone, determined in 16 patients by bioassay after short infusion (15 min) of 1 g imipenem/cilastatin was 4.3 +/- 2.06 mg/kg (geometric mean +/- standard deviation, n = 13) after 45 minutes, and 2.8 +/- 1.86 mg/kg (n = 26) after 88 minutes. Imipenem penetrates into inorganic hyd...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01647497

    authors: Wittmann DH,Kuipers TH,Fock R,Höll M,Bauernfeind A

    更新日期:1986-01-01 00:00:00

  • A stringent preemptive protocol reduces cytomegalovirus disease in the first 6 months after kidney transplantation.

    abstract:BACKGROUND:The optimal strategy to prevent cytomegalovirus (CMV) disease after kidney transplantation continues to be open to debate. The preemptive approach requires regular determination of CMV viremia and prompt initiation of therapy. METHODS:We retrospectively compared the incidence of CMV disease during two perio...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0343-5

    authors: Greiner M,Cusini A,Ruesch M,Schiesser M,Ledergerber B,Fehr T,Mueller NJ

    更新日期:2012-12-01 00:00:00

  • Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.

    abstract:BACKGROUND:Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS:We evaluated the relationship between enterococcal bacteremia and IE by comparing clinical and demographic characteristics of all cases of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-004-2036-1

    authors: Anderson DJ,Murdoch DR,Sexton DJ,Reller LB,Stout JE,Cabell CH,Corey GR

    更新日期:2004-04-01 00:00:00

  • Benefit and advantage to clinicians of a computer-assisted microbiological diagnosis and database system.

    abstract::Computer-assisted diagnostic systems may accelerate transmission of microbiological reports and facilitate evaluation of the epidemiological situation and thus improve the collaboration between microbiologists and clinicians. This possible benefit is demonstrated by four examples. It became evident that incidences of ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01646938

    authors: Manncke K,Heizmann W

    更新日期:1988-01-01 00:00:00

  • [In vitro effect of acylureido penicillins and mezlocillin on anaerobic sporeless gram-negative rods of genus Bacteroides].

    abstract::313 anaerobic gram-negative rods of the Bacteroides genus isolated from 295 clinical specimens were tested for their sensitivity to azlocillin and mezlocillin using the dilution method with agar plates. 25 mg/l of azlocillin inhibited 80.2% of the strains and the same concentration of mezlocillin inhibited 86.9%. The ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640681

    authors: Höhne C

    更新日期:1982-01-01 00:00:00

  • HHV6 meningoencephalitis sequelae in previously healthy children.

    abstract:INTRODUCTION:Human herpes virus 6 (HHV6) infection is a self-limiting illness occurring in early childhood. As with other herpes viruses, the encephalopathy associated with HHV6 is often attributable to the reactivation of a virus previously latent in human brain tissue. Previous reports on HHV6 encephalopathy dealt ma...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-012-0295-9

    authors: Bozzola E,Krzysztofiak A,Bozzola M,Calcaterra V,Quondamcarlo A,Lancella L,Villani A

    更新日期:2012-10-01 00:00:00

  • Epidemiological study of tuberculosis in Palermo, Italy: IS6110 fingerprinting of Mycobacterium tuberculosis strains isolated in the years 1994-1998.

    abstract::In some industrialized countries reemergence of tuberculosis has been recorded. Most cases are thought to be caused by reactivation of infections that had been acquired many years before, but in some geographical areas up to 40% of diagnosed infections have been estimated to be newly acquired, based on the results of ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s150100050036

    authors: Nastasi A,Mammina C

    更新日期:1999-11-01 00:00:00

  • Hepatitis agents with enteric transmission--an epidemiological analysis.

    abstract:BACKGROUND:Viral hepatitis is characterized by special clinical, biochemical and serological findings. This study was planned to determine the seroprevalence, epidemiological characteristics and clinical and biochemical findings of hepatitis A virus (HAV) and hepatitis E virus (HEV) infections during an outbreak of jau...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-002-2123-0

    authors: Yayli G,Kiliç S,Ormeci AR

    更新日期:2002-12-01 00:00:00

  • Ototoxicity and nephrotoxicity of netilmicin.

    abstract::Comparative functional and histological tests were performed in eight groups of ten quinea pigs each, which were administered 50, 75, 100 and 150 mg of netilmicin respecitvely b.i.d. for 29 days, 15 and 25 mg of gentamicin and 50 and 100 mg of amikacin per kg body weight respecitvely b.i.d. and in one control group of...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01638926

    authors: Federspil P

    更新日期:1976-01-01 00:00:00

  • The incidence of fulminant hepatic failure in acute viral hepatitis in Taiwan: increased risk in patients with pre-existing HBsAg carrier state.

    abstract::The incidence of fulminant hepatitis in Taiwan was studied in a series of consecutive 523 patients with acute viral hepatitis including 11 with acute hepatitis A, 67 with acute hepatitis B, 124 with acute hepatitis NANB and 321 acute hepatitis in HBsAg carriers (patients who were HBsAg positive but anti-HBc IgM negati...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01643385

    authors: Chu CM,Liaw YF

    更新日期:1990-07-01 00:00:00

  • A Thr72Ala polymorphism in the NKG2D gene is associated with early symptomatic congenital cytomegalovirus disease.

    abstract::The potential risk factors for congenital cytomegalovirus (cCMV) infection or development of disease remain unclear. Here, we investigated the genetic polymorphisms in natural killer (NK) group 2, member D (NKG2D), an activating receptor expressed on NK cells, and in MHC class I-related chains A, the ligand of NKG2D, ...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-015-0774-x

    authors: Taniguchi R,Koyano S,Suzutani T,Goishi K,Ito Y,Morioka I,Nakamura H,Yamada H,Oka A,Inoue N

    更新日期:2015-06-01 00:00:00

  • Meningitis in a girl with recurrent otitis media caused by Streptococcus pyogenes--otitis media has to be treated appropriately.

    abstract::Streptococcus pyogenes rarely causes meningitis. A recent increase in the incidence and severity of diseases due to S. pyogenes has been observed worldwide, without an apparent increase in the incidence of S. pyogenes meningitis. However, more recently severe and fulminant cases of S. pyogenes meningitis have been rep...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-001-1065-2

    authors: Steppberger K,Adams I,Deutscher J,Müller H,Kiess W

    更新日期:2001-10-01 00:00:00

  • Criteria for the diagnosis of urinary tract infection and for the assessment of therapeutic effectiveness.

    abstract::Three parameters--urinary symptoms, pyuria, and bacteriuria--can be used independently or in combination to define the presence of urinary tract infection. Using these parameters, several approaches to defining urinary infection in various clinical contexts are discussed. Similarly, approaches to the definition and cl...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01704358

    authors: Stamm WE

    更新日期:1992-01-01 00:00:00

  • Moxifloxacin vs ampicillin/sulbactam in aspiration pneumonia and primary lung abscess.

    abstract:BACKGROUND:Aspiration pneumonia (AP) and primary lung abscess (PLA), are diseases following aspiration of infectious material from the oropharynx or stomach. An antibiotic therapy, also covering anaerobic pathogens, is the treatment of choice. In this study we compared moxifloxacin (MXF) and ampicillin/sulbactam (AMP/S...

    journal_title:Infection

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1007/s15010-007-7043-6

    authors: Ott SR,Allewelt M,Lorenz J,Reimnitz P,Lode H,German Lung Abscess Study Group.

    更新日期:2008-02-01 00:00:00

  • Investigation of Rickettsia conorii antibodies in the Antalya area.

    abstract::Mediterranean spotted fever, caused by Rickettsia conorii, is a tick-borne infection. Serum samples for screening R. conorii antibodies of professionally exposed persons in the Antalya region, on the Mediterranean coast of Turkey, were analyzed. R. conorii IgG antibodies were detected in 13 of 98 (13.3%) serum samples...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF02771845

    authors: Vural T,Ergin C,Sayin F

    更新日期:1998-05-01 00:00:00

  • Cefodizime given once daily for the treatment of upper urinary tract infections and complicated lower urinary tract infections.

    abstract::The efficacy of cefodizime (CDZ) in upper urinary tract infections (UUTI) and complicated lower urinary tract infections (LUTI) was assessed by analysis of the combined results of five clinical trials. Doses of CDZ 1 g i.m. daily, 1 x 2 g i.v. or i.m. and 2 x 2 g i.v. were investigated; comparative agents were cefurox...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01709945

    authors: Hofstetter AG

    更新日期:1992-01-01 00:00:00

  • Transintestinal elimination of ciprofloxacin in humans--concomitant assessment of its metabolites in serum, ileum and colon.

    abstract::Ciprofloxacin (200 mg) was infused to seven patients at the beginning of elective colorectal surgery. Thirty minutes after the end of infusion (i.e. 60 min after the start of the operation) ciprofloxacin reached concentrations of 1.60 mg/l in serum and of 3.42-6.07 mg/kg fresh weight in the ileum and colon. During the...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01710676

    authors: Viell B,Krause B,Vestweber KH,Schaaf S,Scholl H

    更新日期:1992-11-01 00:00:00

  • Bacterial meningitis in infants and children.

    abstract::Bacterial meningitis of infants and children exact a major toll worldwide. Haemophilus influenzae, Streptococcus pneumoniae and Neisseria meningitidis continue to be the major causes, and efforts to reduce the incidence of this disease have had limited success. Major advances in rapid diagnosis, such as antigen detect...

    journal_title:Infection

    pub_type: 杂志文章,评审

    doi:10.1007/BF01641744

    authors: Marks MI

    更新日期:1984-01-01 00:00:00

  • ELISA for antibodies to lipid A, lipopolysaccharides and other hydrophobic antigens.

    abstract::A simple, sensitive and rapid ELISA method for the quantification and characterization of antibodies to lipid A has been developed, which can also be applied to other hydrophobic antigens. For coating, antigens were applied to the wells of ELISA plates as solutions in a mixture of chloroform and ethanol 1:9 (v/v), and...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01650719

    authors: Freudenberg MA,Fomsgaard A,Mitov I,Galanos C

    更新日期:1989-09-01 00:00:00

  • [Fosfomycin concentrations in serum and bile (author's transl)].

    abstract::40 patients were given a single, short intravenous infusion of 4 g fosfomycin over a period of five to ten minutes. In 23 patients, the contents of the gall bladder were removed intra-operatively 30-105 minutes after the fosfomycin infusion. In 17 patients who had undergone cholecystectomy eight to ten days earlier, b...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01640831

    authors: Müller O,Rückert U,Walter W,Haag R,Sauer W

    更新日期:1982-01-01 00:00:00

  • Release of TNF alpha and IL6 from human monocytes infected with Mycobacterium kansasii: a comparison to Mycobacterium avium.

    abstract::Tumor necrosis factor alpha (TNF alpha) and interleukin 6 (IL6) are cytokines with a varied spectrum of inflammatory and immunological activities, for example modulation of acute phase proteins, fever and stimulation of B-lymphocytes. Mycobacterium avium has been shown to stimulate the release of TNF alpha and IL6 fro...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01715538

    authors: Stauffer F,Petrow EP,Burgmann H,Graninger W,Georgopoulos A

    更新日期:1994-09-01 00:00:00

  • Women facing HIV. Key question on women with HIV infection: Italian consensus workshop.

    abstract::A panel of leading Italian specialists in infectious diseases, obstetrics and gynaecology met in a national consensus workshop on women facing HIV to review critical aspects and discuss recommendations for selected key questions on four issues: (1) women and highly active antiretroviral therapy (HAART): access to care...

    journal_title:Infection

    pub_type: 共识发展会议,杂志文章

    doi:10.1007/s15010-008-7361-7

    authors: Carosi G,Nasta P,Fiore S,Matteelli A,Cauda R,Ferrazzi E,Tamburrini E,Savasi V,Bini T,Ravizza M,Bucceri A,Vichi F,Murri R,Mazzotta F,d'Arminio Monforte A,Italian Working Group for the Women with HIV Management Guidelines.

    更新日期:2009-04-01 00:00:00

  • Liposome-encapsulated ampicillin against Listeria monocytogenes in vivo and in vitro.

    abstract::In an experimental infection caused by Listeria monocytogenes in mice a considerable enhancement (90-fold) of the therapeutic activity of ampicillin resulting from liposomal encapsulation was observed. The mechanism by which liposomes improved the therapeutic index of ampicillin in this infection appeared to be an inc...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/BF01639742

    authors: Bakker-Woudenberg IA,Lokerse AF,Vink-van den Berg JC,Roerdink FH

    更新日期:1988-01-01 00:00:00

  • Strategies to enhance rational use of antibiotics in hospital: a guideline by the German Society for Infectious Diseases.

    abstract:INTRODUCTION:In the time of increasing resistance and paucity of new drug development there is a growing need for strategies to enhance rational use of antibiotics in German and Austrian hospitals. An evidence-based guideline on recommendations for implementation of antibiotic stewardship (ABS) programmes was developed...

    journal_title:Infection

    pub_type: 杂志文章

    doi:10.1007/s15010-016-0885-z

    authors: de With K,Allerberger F,Amann S,Apfalter P,Brodt HR,Eckmanns T,Fellhauer M,Geiss HK,Janata O,Krause R,Lemmen S,Meyer E,Mittermayer H,Porsche U,Presterl E,Reuter S,Sinha B,Strauß R,Wechsler-Fördös A,Wenisch C,Kern

    更新日期:2016-06-01 00:00:00