Abstract:
:Pefloxacin was applied to a newborn suffering from ventriculitis caused by Klebsiella pneumoniae after failure of routine antibiotics. Treatment was successful. Blood and CSF levels were high, thus documenting good CSF penetration. In addition to this case report, a review of the literature regarding seven neonates with CNS infection treated with fluoroquinolones and from whom CSF levels were obtained, is presented. In conclusion, due to their excellent activity against gram-negative microorganisms, fluoroquinolones may be considered in the treatment of neonatal CNS infections if the pathogen is resistant to routinely used antibiotics. Only limited experience is available with fluoroquinolones in pediatric patients given their potential for cartilage toxicity in young animals.
journal_name
Infectionjournal_title
Infectionauthors
Linder N,Dagan R,Kuint J,Keler N,Keren G,Reichman Bdoi
10.1007/BF01716707subject
Has Abstractpub_date
1994-05-01 00:00:00pages
210-2issue
3eissn
0300-8126issn
1439-0973journal_volume
22pub_type
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