Four-year experience with a recombinant hepatitis B vaccine.

Abstract:

:Three hundred and forty-three healthy adults were vaccinated with five different lots of recombinant hepatitis B vaccine. Three hundred and forty (99.1%) individuals produced antibodies against hepatitis B surface antigen (anti-HBs). Peak anti-HBs concentrations were significantly higher in females and younger individuals. All anti-HBs positive individuals developed antibodies to the common determinant "a" of HBsAg. The vaccine was well tolerated, without severe side reactions. Persistence of anti-HBs was followed in 130 individuals for 3, and in 15 for 4 years after the first vaccination of these two groups. 21.7% and 32.3%, respectively, no longer had protective levels of anti-HBs after this time. The persistence of anti-HBs was dependent on peak anti-HBs levels, with consistent kinetics of anti-HBs decline. Revaccination of individuals whose specific antibody levels had fallen below 10 IU/l led to a prompt anti-HBs response. Comparison with individuals vaccinated with plasma-derived hepatitis B vaccine revealed no substantial differences between the two vaccines.

journal_name

Infection

journal_title

Infection

authors

Jilg W,Schmidt M,Deinhardt F

doi

10.1007/BF01646879

subject

Has Abstract

pub_date

1989-03-01 00:00:00

pages

70-6

issue

2

eissn

0300-8126

issn

1439-0973

journal_volume

17

pub_type

杂志文章
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    doi:10.1007/BF01743362

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    pub_type: 杂志文章

    doi:10.1007/BF01709955

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    更新日期:1992-01-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2000-05-01 00:00:00

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    journal_title:Infection

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  • Guillain-Barré syndrome associated with Mycobacterium bovis lymphadenitis.

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    journal_title:Infection

    pub_type: 杂志文章

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    更新日期:2015-10-01 00:00:00

  • Clinical characteristics of Raoultella ornithinolytica bacteremia.

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    更新日期:2015-02-01 00:00:00

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    更新日期:1996-01-01 00:00:00

  • A survey of ATRIPLA use in clinical practice as first-line therapy in HIV-positive persons in Europe.

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    authors: Mocroft A,Reiss P,Rakhmanova A,Banhegyi D,Phillips AN,De Wit S,Ristola M,Lundgren JD,Grarup J,Kirk O,EuroSIDA in EuroCOORD.

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    doi:10.1007/BF02033066

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    pub_type: 杂志文章,评审

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  • HHV6 meningoencephalitis sequelae in previously healthy children.

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    pub_type: 杂志文章

    doi:10.1007/s15010-012-0295-9

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    journal_title:Infection

    pub_type: 杂志文章

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    pub_type: 杂志文章

    doi:10.1007/BF01639903

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    更新日期:1980-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.1007/BF01642766

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  • Detection of SARS-CoV-2 in conjunctival secretions from patients without ocular symptoms.

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    pub_type: 杂志文章

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    pub_type: 杂志文章,评审

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    更新日期:2015-04-01 00:00:00

  • Femoral osteomyelitis due to Cladophialophora arxii in a patient with chronic granulomatous disease.

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    pub_type: 临床试验,杂志文章

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    pub_type: 杂志文章

    doi:10.1007/BF01713044

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    pub_type: 杂志文章

    doi:10.1007/BF01641124

    authors: Dette GA,Finke U

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    pub_type: 杂志文章,评审

    doi:10.1007/BF01641744

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