[Pseudomonas aeruginosa immunoglobulin in experimental pneumonia].

Abstract:

:A guinea pig model of experimental Pseudomonas aeruginosa pneumonia was used to evaluate factors affecting the efficacy of passive immune therapy with Psomaglobin N, a hyperimmune P. aeruginosa globulin. Animals treated 2 h after infection with a single intravenous infusion of Psomaglobin N, 500 mg/kg, demonstrated 33% survival. Lower dosages were less effective and no survivors occurred among albumin-treated controls. Treatment with Psomaglobin N was effective if given 2 h or 8 h after infection but not if delayed until 24 h after infection. Animals rendered neutropenic with cyclophosphamide did not survive if treated with Psomaglobin N alone. However, when Psomaglobin N was added to tobramycin treatment, a significant increase in survival occurred (86%) as compared to that observed with tobramycin alone (43%) (p less than 0.05). We conclude that Psomaglobin N may offer a useful therapeutic option in management of P. aeruginosa pneumonia.

journal_name

Infection

journal_title

Infection

authors

Pennington JE,Pier GB

doi

10.1007/BF01646124

subject

Has Abstract

pub_date

1987-01-01 00:00:00

pages

56-9

issue

1

eissn

0300-8126

issn

1439-0973

journal_volume

15

pub_type

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