Abstract:
:Lung cancer is the deadliest cancer worldwide. The mutational frequency of EGFR and KRAS genes in lung adenocarcinoma varies worldwide per ethnicity and smoking. The impact of EGFR and KRAS mutations in Brazilian lung cancer remains poorly explored. Thus, we investigated the frequency of EGFR and KRAS mutations in a large Brazilian series of lung adenocarcinoma together with patients' genetic ancestry, clinicopathological and sociodemographic characteristics. The mutational frequency of EGFR was 22.7% and KRAS was 20.4%. The average ancestry proportions were 73.1% for EUR, 13.1% for AFR, 6.5% for AME and 7.3% for ASN. EGFR mutations were independently associated with never-smokers, high-Asian ancestry, and better performance status. KRAS mutations were independently associated with tobacco exposure and non-Asian ancestry. EGFR-exon 20 mutations were associated with worse outcome. The Cox regression model indicated a worse outcome for patients whose were older at diagnosis (>61 y), solid histological subtype, loss of weight (>10%), worse performance status (≥2), and presence of KRAS mutations and EGFR mutational status in TKi non-treated patients. In conclusion, we assessed the clinicopathological and ethnic impact of EGFR and KRAS mutations in the largest series reported of Brazilian lung adenocarcinomas. These findings can support future clinical strategies for Brazilian lung cancer patients.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Leal LF,de Paula FE,De Marchi P,de Souza Viana L,Pinto GDJ,Carlos CD,Berardinelli GN,Miziara JE,da Silva CM,Silva ECA,Pereira R,de Oliveira MA,Scapulatempo-Neto C,Reis RMdoi
10.1038/s41598-019-39965-xsubject
Has Abstractpub_date
2019-03-01 00:00:00pages
3209issue
1issn
2045-2322pii
10.1038/s41598-019-39965-xjournal_volume
9pub_type
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