Abstract:
:C-reactive protein (CRP) is an acute-phase plasma protein that can be used as a biomarker for activation of the immune system. A spectral analysis of CRP level over time for patients with gynaecological tumours has been reported by Madondo et al., using a periodogram method, suggesting that there is no significant periodicity in the data. In our study, we investigate the impact of low sample number on periodogram analysis, for non-uniform sampling intervals-we conclude that data of Madondo et al. cannot rule out periodic behaviour. The search for patterns (periodic or otherwise) in the CRP time-series is of interest for providing a cue for the optimal times at which cancer therapies are best administered. In this paper we show (i) there is no evidence to rule out periodicity in CRP levels, and (ii) we provide a prescription for the minimum data sample rate required in future experiments for improved testing of a periodic CRP signal hypothesis. The analysis we provide may be used for establishing periodicity in any short time-series signal that is observed without a priori information.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Dorraki M,Fouladzadeh A,Salamon SJ,Allison A,Coventry BJ,Abbott Ddoi
10.1038/s41598-018-30469-8subject
Has Abstractpub_date
2018-08-10 00:00:00pages
11979issue
1issn
2045-2322pii
10.1038/s41598-018-30469-8journal_volume
8pub_type
杂志文章abstract::Stimulation with lipopolysaccharide (LPS; endotoxin) not only causes rapid production of proinflammatory cytokines, but also induces a state of LPS hypo-responsiveness to a second LPS stimulation (endotoxin tolerance (ET)). Murine bone marrow-derived MCs (BMMCs) and peritoneal MCs (PMCs) developed ET as shown by an ab...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-04890-4
更新日期:2017-07-03 00:00:00
abstract::An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title:Scientific reports
pub_type: 已发布勘误
doi:10.1038/s41598-020-60956-w
更新日期:2020-02-26 00:00:00
abstract::Noisy galvanic vestibular stimulation (nGVS) delivered at imperceptible intensities can improve vestibular function in health and disease. Here we evaluated whether nGVS effects on vestibular function are only present during active stimulation or may exhibit relevant post-stimulation after-effects. Initially, nGVS amp...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-020-59374-9
更新日期:2020-02-13 00:00:00
abstract::Bisphenol A (BPA) is one of the commonest Endocrine Disruptor Compounds worldwide. It interferes with vertebrate reproduction, possibly by inducing deregulation of epigenetic mechanisms. To determine its effects on female reproductive physiology and investigate whether changes in the expression levels of genes related...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep21982
更新日期:2016-02-25 00:00:00
abstract::Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract of uncertain origin, which includes ulcerative colitis (UC) and Crohn's disease (CD). The composition of gut microbiota may change in IBD affected individuals, but whether dysbiosis is the cause or the consequence of infla...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-10034-5
更新日期:2017-08-25 00:00:00
abstract::Drug addiction remains a prevalent and fatal disease worldwide that carries significant social and economic impacts. Recent reports suggest illicit pregabalin (Lyrica) use may be increasing among youth, however the addictive potential of pregabalin has not been well established. Drug seeking behavior and chronic drug ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-51556-4
更新日期:2019-10-22 00:00:00
abstract::We report low-temperature solution-processed p-CuO nanorods (NRs)/n-ZnO NRs heterojunction light emitting diode (LED), exploiting the native point defects of ZnO NRs. ZnO NRs were synthesized at 90 °C by using hydrothermal method while CuO NRs were synthesized at 100 °C by using microwave reaction system. The electric...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep17961
更新日期:2015-12-09 00:00:00
abstract::Aquaporins (AQPs) are a ubiquitous family of transmembrane water channel proteins. A subgroup of AQP water channels also facilitates transmembrane diffusion of small, polar solutes. A constriction within the pore, the aromatic/arginine (ar/R) selectivity filter, is thought to control solute permeability: previous stud...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56814-z
更新日期:2019-12-30 00:00:00
abstract::Crypt neurons are a third type of olfactory receptor neurons with a highly unusual "one cell type--one receptor" mode of expression, the same receptor being expressed by the entire population of crypt neurons. Attempts to identify the target region(s) of crypt neurons have been inconclusive so far. We report that TrkA...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep02063
更新日期:2013-01-01 00:00:00
abstract::Confocal Raman spectroscopy (CRS) can provide information about oocyte competency through measurement of changes in the macromolecular architecture during oocyte development and maturation. Hitherto most spectroscopic studies have been limited to fixed oocytes due to the inherent difficulties working with live cells. ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-08973-0
更新日期:2017-08-21 00:00:00
abstract::Living organisms dynamically and flexibly operate a great number of components. As one of such redundant control mechanisms, low-dimensional coordinative structures among multiple components have been investigated. However, structures extracted from the conventional statistical dimensionality reduction methods do not ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-53187-1
更新日期:2019-11-14 00:00:00
abstract::Modified constraint-induced movement therapy (mCIMT) improves upper limb (UL) motor execution in unilateral cerebral palsy (uCP). As these children also show motor planning deficits, action-observation training (AOT) might be of additional value. Here, we investigated the combined value of AOT to mCIMT on UL kinematic...
journal_title:Scientific reports
pub_type: 杂志文章,随机对照试验
doi:10.1038/s41598-020-67427-2
更新日期:2020-06-26 00:00:00
abstract::In the present study, a surface-active enzyme, lipase was immobilized in polyethyleneimine (PEI) microcapsules and then modified with oxidized multiwall carbon nanotubes (MWCNTs). The resulting lipase microcapsules exhibited higher activity and stability, since the activity of microcapsules was 21.9 folds than that of...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep29670
更新日期:2016-07-18 00:00:00
abstract::In most organisms, ribosomal RNA (rRNA) contributes to >85% of total RNA. Thus, to obtain useful information from RNA-sequencing (RNA-seq) analyses at reasonable sequencing depth, typically, mature polyadenylated transcripts are enriched or rRNA molecules are depleted. Targeted depletion of rRNA is particularly useful...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-48692-2
更新日期:2019-08-22 00:00:00
abstract::Little information is available on chemical forms of heavy metals on integrate plant roots. KNO3 (1 M), 0.05M EDTA at pH6 and 0.01 M HCl were used sequentially to extract the exchangeable, complexed and precipitated forms of Cu(II) and Cd(II) from soybean roots and then to investigate chemical form distribution of Cu(...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep36373
更新日期:2016-11-02 00:00:00
abstract::A 3D cell culture is preferred to 2D cell culture since it allows cells to grow in all directions in vitro, similar to how they would in vivo. 3D cell culture plates currently used in tissue engineering research have limited access to control the geometry. Furthermore, 3D cell culture plate manufacturing methods are r...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-50186-0
更新日期:2019-09-27 00:00:00
abstract::The biological function of sterol glucosides (SGs), the most abundant sterol derivatives in higher plants, remains uncertain. In an effort to improve our understanding of these membrane lipids we examined phenotypes exhibited by the roots of Arabidopsis (Arabidopsis thaliana) lines carrying insertions in the UDP-Glc:s...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-017-05925-6
更新日期:2017-07-18 00:00:00
abstract::T helper 17 (Th17) cells not only play critical roles in protecting against bacterial and fungal infections but are also involved in the pathogenesis of autoimmune diseases. The retinoic acid-related orphan receptor (RORγt) is a key transcription factor involved in Th17 cell differentiation through direct transcriptio...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep16355
更新日期:2015-11-09 00:00:00
abstract::We study complex scaling properties of RR and QT intervals of electrocardiograms (ECGs) with their equivalences at the cellular level, that is, inter-beat intervals (IBI) and field potential durations (FPD) of spontaneously beating human-induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) aggregates. Our de...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-40247-9
更新日期:2019-03-06 00:00:00
abstract::Pre-stimulus alpha (8-12 Hz) and beta (16-20 Hz) oscillations have been frequently linked to the prediction of upcoming sensory input. Do these frequency bands serve as a neural marker of linguistic prediction as well? We hypothesized that if pre-stimulus alpha and beta oscillations index language predictions, their p...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-56600-x
更新日期:2019-12-27 00:00:00
abstract::Extensive mapping of neuronal connections in the central nervous system requires high-throughput µm-scale imaging of large volumes. In recent years, different approaches have been developed to overcome the limitations due to tissue light scattering. These methods are generally developed to improve the performance of a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep09808
更新日期:2015-05-07 00:00:00
abstract::Numerous studies have investigated the association between eosinophilia and clinical outcome of patients with chronic obstructive pulmonary disease (COPD) but the evidence is conflicting. We conducted a pooled analysis of outcome measures comparing eosinophilic and non-eosinophilic COPD patients. We searched articles ...
journal_title:Scientific reports
pub_type: 杂志文章,meta分析
doi:10.1038/s41598-017-13745-x
更新日期:2017-10-18 00:00:00
abstract::Multiple sclerosis is a chronic, autoimmune and neurodegenerative disease affecting multiple functional systems and resulting in motor impairments associated with muscle weakness and lack of movement coordination. We quantified upper limb motor deficits with a robot-based assessment including behavioral and muscle syn...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-20343-y
更新日期:2018-02-01 00:00:00
abstract::The temporal correspondence between two arbitrarily chosen pairs of alternating features can generally be reported for rates up to 3-4 Hz. This limit is however surpassed for specialised visual mechanisms that encode conjunctions of features. Here we show that this 3-4 Hz limit is exceeded for eye gaze and eyebrow pai...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-27242-2
更新日期:2018-06-13 00:00:00
abstract::The Yiyuan hominin fossil site is one of the few localities in China where a partial skullcap and several loose teeth of Homo erectus have been discovered. Yiyuan was previously assigned broadly to the Middle Pleistocene by biostratigraphical correlation and ESR/U-series dating. Here, we report the first application o...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-019-43401-5
更新日期:2019-05-06 00:00:00
abstract::All models of evolution of human behaviour depend on the correct identification and interpretation of bone surface modifications (BSM) on archaeofaunal assemblages. Crucial evolutionary features, such as the origin of stone tool use, meat-eating, food-sharing, cooperation and sociality can only be addressed through co...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-24071-1
更新日期:2018-04-10 00:00:00
abstract::While there is a rich literature on transcription dynamics during the development of many organisms, protein data is limited. We used iTRAQ isotopic labeling and mass spectrometry to generate the largest developmental proteomic dataset for any animal. Expression dynamics of nearly 4,000 proteins of Xenopus laevis was ...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep04365
更新日期:2014-03-14 00:00:00
abstract::Estrogen deprivation aggravates cardiac injury after myocardial ischemia and reperfusion (I/R) injury. Although either estrogen or the dipeptidyl peptidase-4 (DPP-4) inhibitor, vildagliptin, reduces myocardial damage following cardiac I/R, their effects on the heart in obese-insulin resistant and estrogen deprived con...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep44306
更新日期:2017-03-10 00:00:00
abstract::The influence of meteorological determinants on tuberculosis (TB) incidence remains severely under-discussed, especially through the perspective of time series analysis. In the current study, we used a distributed lag nonlinear model (DLNM) to analyze a 10-year series of consecutive surveillance data. We found that, a...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/s41598-018-28426-6
更新日期:2018-07-03 00:00:00
abstract::Balancing stomata-dependent CO2 assimilation and transpiration is a key challenge for increasing crop productivity and water use efficiency under drought stress for sustainable crop production worldwide. Here, we show that cucumber and luffa plants with luffa as rootstock have intrinsically increased water use efficie...
journal_title:Scientific reports
pub_type: 杂志文章
doi:10.1038/srep20212
更新日期:2016-02-02 00:00:00