On detection of periodicity in C-reactive protein (CRP) levels.

Abstract:

:C-reactive protein (CRP) is an acute-phase plasma protein that can be used as a biomarker for activation of the immune system. A spectral analysis of CRP level over time for patients with gynaecological tumours has been reported by Madondo et al., using a periodogram method, suggesting that there is no significant periodicity in the data. In our study, we investigate the impact of low sample number on periodogram analysis, for non-uniform sampling intervals-we conclude that data of Madondo et al. cannot rule out periodic behaviour. The search for patterns (periodic or otherwise) in the CRP time-series is of interest for providing a cue for the optimal times at which cancer therapies are best administered. In this paper we show (i) there is no evidence to rule out periodicity in CRP levels, and (ii) we provide a prescription for the minimum data sample rate required in future experiments for improved testing of a periodic CRP signal hypothesis. The analysis we provide may be used for establishing periodicity in any short time-series signal that is observed without a priori information.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Dorraki M,Fouladzadeh A,Salamon SJ,Allison A,Coventry BJ,Abbott D

doi

10.1038/s41598-018-30469-8

subject

Has Abstract

pub_date

2018-08-10 00:00:00

pages

11979

issue

1

issn

2045-2322

pii

10.1038/s41598-018-30469-8

journal_volume

8

pub_type

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