3D printing of sacrificial templates into hierarchical porous materials.

abstract：:Osteochondral defects contain damage to both the articular cartilage and underlying subchon- dral bone, which remains a significant challenge in orthopedic surgery. Layered structure of bone, cartilage and the bone-cartilage interface must be taken into account in the case of biofabrication of the osteochondral (OC) i...

journal_title：Scientific reports

authors： Ayan B,Wu Y,Karuppagounder V,Kamal F,Ozbolat IT

更新日期：2020-08-04 00:00:00

abstract：:Recently, long non-coding RNAs (lncRNAs) have emerged as an important class of molecules involved in many cellular processes. One of their primary functions is to shape epigenetic landscape through interactions with chromatin modifying proteins. However, mechanisms contributing to the specificity of such interactions ...

journal_title：Scientific reports

authors： Tu S,Yuan GC,Shao Z

更新日期：2017-01-31 00:00:00

abstract：:An important number of healthy and diseased tissues shows spatial variations in their metabolic capacities across the tissue. The liver is a prime example of such heterogeneity where the gradual changes in various metabolic activities across the liver sinusoid is termed as "zonation" of the liver. Here, we introduce t...

journal_title：Scientific reports

authors： Kang YBA,Eo J,Mert S,Yarmush ML,Usta OB

更新日期：2018-06-12 00:00:00

abstract：:On standard electrocardiogram (ECG) PQ interval is known to be moderately heart rate dependent, but no physiologic details of this dependency have been established. At the same time, PQ dynamics is a clear candidate for non-invasive assessment of atrial abnormalities including the risk of atrial fibrillation. We studi...

journal_title：Scientific reports

authors： Toman O,Hnatkova K,Smetana P,Huster KM,Šišáková M,Barthel P,Novotný T,Schmidt G,Malik M

更新日期：2020-02-13 00:00:00

abstract：:Modulating the tumor microenvironment to promote an effective immune response is critical in managing any type of tumor. Melanoma is an aggressive skin cancer and the incidence rate is increasing worldwide. Potent protease inhibitors have recently been extensively researched as potential therapeutic agents against var...

journal_title：Scientific reports

authors： Ranasinghe SL,Rivera V,Boyle GM,McManus DP

更新日期：2019-11-07 00:00:00

abstract：:Compared with the commercially available single nucleotide polymorphism (SNP) chip based on the Bead Chip technology, the solution hybrid selection (SHS)-based target enrichment SNP chip is not only design-flexible, but also cost-effective for genotype sequencing. In this study, we propose to design an animal SNP chip...

journal_title：Scientific reports

authors： Qiao X,Su R,Wang Y,Wang R,Yang T,Li X,Chen W,He S,Jiang Y,Xu Q,Wan W,Zhang Y,Zhang W,Chen J,Liu B,Liu X,Fan Y,Chen D,Jiang H,Fang D,Liu Z,Wang X,Zhang Y,Mao D,Wang Z,Di R,Zhao Q,Zhong T,Yang H,Wa

更新日期：2017-08-17 00:00:00

abstract：:The emergence of single-cell RNA sequencing (scRNA-seq) technologies has enabled us to measure the expression levels of thousands of genes at single-cell resolution. However, insufficient quantities of starting RNA in the individual cells cause significant dropout events, introducing a large number of zero counts in t...

journal_title：Scientific reports

authors： Talwar D,Mongia A,Sengupta D,Majumdar A

更新日期：2018-11-05 00:00:00

abstract：:Perovskite LaFeO3/montmorillonite nanocomposites (LaFeO3/MMT) have been successfully prepared via assembling LaFeO3 nanoparticles on the surface of montmorillonite with citric acid assisted sol-gel method. The results indicated that the uniform LaFeO3 nanoparticles were densely deposited onto the surface of montmorill...

journal_title：Scientific reports

authors： Peng K,Fu L,Yang H,Ouyang J

更新日期：2016-01-18 00:00:00

abstract：:In this letter, making use of real gait force profiles of healthy and patient groups with Parkinson disease which have different disease severity in terms of Hoehn-Yahr stage, we calculate various heuristic complexity measures of the recurrence quantification analysis (RQA). Using this technique, we are able to evince...

journal_title：Scientific reports

authors： Afsar O,Tirnakli U,Marwan N

更新日期：2018-06-14 00:00:00

abstract：:Telomeres, the protective, terminal parts of the chromosomes erode during cell division and as a result of oxidative damage by reactive oxygen species (ROS). Ectotherms rely on the ambient temperature for maintaining temperature-dependent metabolic rate, regulated through behavioural thermoregulation. Their temperatur...

journal_title：Scientific reports

authors： Axelsson J,Wapstra E,Miller E,Rollings N,Olsson M

更新日期：2020-01-13 00:00:00

abstract：:Neutrophil gelatinase-associated lipocalin (NGAL, lipocalin 2 or LCN2) is an iron carrier protein whose circulating level is increased by kidney injury, bacterial infection and obesity, but its metabolic consequence remains elusive. To study physiological role of LCN2 in energy homeostasis, we challenged female Lcn2 k...

journal_title：Scientific reports

authors： Ishii A,Katsuura G,Imamaki H,Kimura H,Mori KP,Kuwabara T,Kasahara M,Yokoi H,Ohinata K,Kawanishi T,Tsuchida J,Nakamoto Y,Nakao K,Yanagita M,Mukoyama M,Mori K

更新日期：2017-11-14 00:00:00

abstract：:The purpose of this study was to find the circulating microRNAs (miRNAs) co-related with the severity of coronary artery calcification (CAC), and testify whether the selected miRNAs could reflect the obstructive coronary artery disease in symptomatic patients. Patients with chest pain and moderated risk for coronary a...

journal_title：Scientific reports

authors： Liu W,Ling S,Sun W,Liu T,Li Y,Zhong G,Zhao D,Zhang P,Song J,Jin X,Xu Z,Song H,Li Q,Liu S,Chai M,Dai Q,He Y,Fan Z,Zhou YJ,Li Y

更新日期：2015-11-05 00:00:00

abstract：:The xeroderma pigmentosum group C (XPC) protein complex is a key factor that detects DNA damage and initiates nucleotide excision repair (NER) in mammalian cells. Although biochemical and structural studies have elucidated the interaction of XPC with damaged DNA, the mechanism of its regulation in vivo remains to be u...

journal_title：Scientific reports

authors： Akita M,Tak YS,Shimura T,Matsumoto S,Okuda-Shimizu Y,Shimizu Y,Nishi R,Saitoh H,Iwai S,Mori T,Ikura T,Sakai W,Hanaoka F,Sugasawa K

更新日期：2015-06-04 00:00:00

abstract：:Competition between simultaneously presented visual stimuli lengthens reaction time and reduces both the BOLD response and neural firing. In contrast, conditions of sequential presentation have been assumed to be free from competition. Here we manipulated the spatial proximity of stimuli (Near versus Far conditions) t...

journal_title：Scientific reports

authors： Ahmad J,Swan G,Bowman H,Wyble B,Nobre AC,Shapiro KL,McNab F

更新日期：2017-07-06 00:00:00

abstract：:Understanding the molecular mechanisms underlying Alzheimer's disease (AD) is necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore important to detect the most important genes and miRNAs, which are associated with molecular events, and studying their interactions for recognitio...

journal_title：Scientific reports

authors： Moradifard S,Hoseinbeyki M,Ganji SM,Minuchehr Z

更新日期：2018-03-19 00:00:00

abstract：:Antimonite [Sb(III)]-oxidizing bacteria can transform the toxic Sb(III) into the less toxic antimonate [Sb(V)]. Recently, the cytoplasmic Sb(III)-oxidase AnoA and the periplasmic arsenite [As(III)] oxidase AioAB were shown to responsible for bacterial Sb(III) oxidation, however, disruption of each gene only partially ...

journal_title：Scientific reports

authors： Li J,Yang B,Shi M,Yuan K,Guo W,Wang Q,Wang G

更新日期：2017-03-02 00:00:00

abstract：:Limbal stem cell deficiency can be treated with transplantation of cultured human limbal epithelial cells (LEC). It can be advantageous to produce LEC in centralized labs and thereafter ship them to eye clinics. The present study used transport simulations of LEC to determine if vigorous shaking during transport alter...

journal_title：Scientific reports

authors： Utheim OA,Lyberg T,Eidet JR,Raeder S,Sehic A,Roald B,Messelt E,de la Paz MF,Dartt DA,Utheim TP

更新日期：2018-07-12 00:00:00

abstract：:Proteins that act as global transcriptional regulators play key roles in bacterial adaptation to new niches. These proteins recognize multiple DNA sites across the bacterial genome by different mechanisms. Enterococcus faecalis is able to survive in various niches of the human host, either as a commensal or as a leadi...

journal_title：Scientific reports

authors： Ruiz-Cruz S,Moreno-Blanco A,Espinosa M,Bravo A

更新日期：2019-04-16 00:00:00

abstract：:An available pathway to prepare the ionized covalent organic nanosheets (iCONs) has been proposed by a metal-assisted aqueous-phase exfoliation route from covalent organic frameworks. The soluble and belt-shaped iCONs could immobilize a large quantity of proteins (2.73 mg/mg, BSA/iCONs) and hence serve as transporters...

journal_title：Scientific reports

authors： Kong W,Wan J,Namuangruk S,Guo J,Wang C

更新日期：2018-04-03 00:00:00

abstract：:Freshwater mussels are ecosystem engineers and keystone species in aquatic environments. Unfortunately, due to dramatic declines this fauna is among the most threatened globally. Here, we clarify the taxonomy and biogeography of Russian Unionidae species based on the most comprehensive multi-locus dataset sampled to d...

journal_title：Scientific reports

authors： Bolotov IN,Kondakov AV,Konopleva ES,Vikhrev IV,Aksenova OV,Aksenov AS,Bespalaya YV,Borovskoy AV,Danilov PP,Dvoryankin GA,Gofarov MY,Kabakov MB,Klishko OK,Kolosova YS,Lyubas AA,Novoselov AP,Palatov DM,Savvinov GN,Solom

更新日期：2020-02-20 00:00:00

abstract：:The ability to generate germ cells from pluripotent stem cells (PSCs) is valuable for human regenerative medicine and animal breeding. Germ cell-like cells (GCLCs) have been differentiated from mouse and human PSCs, but not from porcine PSCs, which are considered an ideal model for stem cell applications. Here, we dev...

journal_title：Scientific reports

authors： Wang H,Xiang J,Zhang W,Li J,Wei Q,Zhong L,Ouyang H,Han J

更新日期：2016-06-06 00:00:00

abstract：:Genetic epidemiological studies show that genetic factors contribute significantly to cervical cancer carcinogenesis. Several genome-wide association studies (GWAS) have revealed novel genetic variants associated with cervical cancer susceptibility. We aim to replicate 4 GWAS-identified single nucleotide polymorphisms...

journal_title：Scientific reports

authors： Yang YC,Chang TY,Chen TC,Lin WS,Lin CL,Lee YJ

更新日期：2018-10-17 00:00:00

abstract：:Non-traumatic osteonecrosis (ON) of the femoral head is a common disease affecting a young population as the peak age of diagnosis is in the 40 s. The natural history of non-traumatic ON leads to a collapse of the femoral head requiring prosthetic replacement in a 60% of cases. Although trabecular bone involvement in ...

journal_title：Scientific reports

authors： Pascart T,Falgayrac G,Migaud H,Quinchon JF,Norberciak L,Budzik JF,Paccou J,Cotten A,Penel G,Cortet B

更新日期：2017-03-07 00:00:00

abstract：:Transparent anti-fogging and self-cleaning coatings are of great interest for many applications, including solar panels, windshields and displays or lenses to be used in humid environments. In this paper, we report on the simultaneous synthesis, at atmospheric pressure, of anatase TiO2 nanoparticles and low-temperatur...

journal_title：Scientific reports

authors： Chemin JB,Bulou S,Baba K,Fontaine C,Sindzingre T,Boscher ND,Choquet P

更新日期：2018-06-25 00:00:00

abstract：:Neutrophil elastase (NE) suppresses IL-8/CXCL8 in human airway smooth muscle cells (hASM) while stimulating its production in respiratory epithelial cells. This differential effect is mediated by the selective induction of NKRF and dysregulation in chronic inflammatory diseases. We hypothesized that the differential a...

journal_title：Scientific reports

authors： Ho SC,Wu SM,Feng PH,Liu WT,Chen KY,Chuang HC,Chan YF,Kuo LW,Lee KY

更新日期：2017-03-21 00:00:00

abstract：:We describe a technique for imaging single mRNAs in living cells based on fluorescent protein (FP) complementation. We employ the high affinity interaction between the bacterial phage MS2/PP7 coat proteins and their respective RNA binding motifs as an RNA scaffold to bring two halves of a split-FP together to image si...

journal_title：Scientific reports

authors： Wu B,Chen J,Singer RH

更新日期：2014-01-09 00:00:00

abstract：:Current studies addressing the influence of interleukin-33 or its receptor (IL-33R/ST2) on development of atopic dermatitis-like inflammation in mice have reported conflicting results. We compared the response in single- and double-deficient IL-33-/-/ST2-/- C57BL/6J BomTac mice in the well-established calcipotriol-ind...

journal_title：Scientific reports

authors： Pietka W,Sundnes O,Hammarström C,Zucknick M,Khnykin D,Haraldsen G

更新日期：2020-04-15 00:00:00

abstract：:The role of changes in dopamine neuronal activity during the development of symptoms in affective disorders remains controversial. Here, we show that inactivation of NMDA receptors on dopaminergic neurons in adult mice led to the development of affective disorder-like symptoms. The loss of NMDA receptors altered activ...

journal_title：Scientific reports

authors： Jastrzębska K,Walczak M,Cieślak PE,Szumiec Ł,Turbasa M,Engblom D,Błasiak T,Parkitna JR

更新日期：2016-11-17 00:00:00

abstract：:Cell biology is increasingly dependent on quantitative methods resulting in the need for microscopic labelling technologies that are highly sensitive and specific. Whilst the use of fluorescent proteins has led to major advances, they also suffer from their relatively low brightness and photo-stability, making the det...

journal_title：Scientific reports

authors： Lepore A,Taylor H,Landgraf D,Okumus B,Jaramillo-Riveri S,McLaren L,Bakshi S,Paulsson J,Karoui ME

更新日期：2019-05-27 00:00:00

abstract：:The transglutaminase (TG) family comprises eight isozymes that form the isopeptide bonds between glutamine and lysine residues and contribute to the fibrotic diseases via crosslinking-mediated stabilization of ECM and the activation of TGF-β in several tissues. However, despite a growing body of evidence implicating T...

journal_title：Scientific reports

authors： Tatsukawa H,Tani Y,Otsu R,Nakagawa H,Hitomi K

更新日期：2017-03-22 00:00:00