Abstract：
:Understanding the molecular mechanisms underlying Alzheimer's disease (AD) is necessary for the diagnosis and treatment of this neurodegenerative disorder. It is therefore important to detect the most important genes and miRNAs, which are associated with molecular events, and studying their interactions for recognition of AD mechanisms. Here we focus on the genes and miRNAs expression profile, which we have detected the miRNA target genes involved in AD. These are the most quintessential to find the most important miRNA, to target genes and their important pathways. A total of 179 differentially expressed miRNAs (DEmiRs) and 1404 differentially expressed genes (DEGs) were obtained from a comprehensive meta-analysis. Also, regions specific genes with their molecular function in AD have been demonstrated. We then focused on miRNAs which regulated most genes in AD, alongside we analyzed their pathways. The miRNA-30a-5p and miRNA-335 elicited a major function in AD after analyzing the regulatory network, we showed they were the most regulatory miRNAs in the AD. In conclusion, we demonstrated the most important genes, miRNAs, miRNA-mRNA interactions and their related pathways in AD using Bioinformatics methods. Accordingly, our defined genes and miRNAs could be used for future molecular studies in the context of AD.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Moradifard S,Hoseinbeyki M,Ganji SM,Minuchehr Zdoi
10.1038/s41598-018-20959-0subject
Has Abstractpub_date
2018-03-19 00:00:00pages
4767issue
1issn
2045-2322pii
10.1038/s41598-018-20959-0journal_volume
8pub_type
杂志文章,meta分析abstract：:Least component-based delivery of drug-tagged-nanocarriers across blood-brain-barriers (BBB) will allow site-specific and on-demand release of therapeutics to prevent CNS diseases. We developed a non-invasive magnetically guided delivery of magneto-electric nanocarriers (MENCs), ~20 nm, 10 mg/kg, across BBB in C57Bl/J...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep25309
更新日期：2016-05-04 00:00:00
abstract：:Deleterious mutations in patchd1 domain containing 1 (PTCHD1) gene have been identified in patients with intellectual disability and/or autism spectrum disorder (ASD). To clarify the causal relationship between Ptchd1 deficiency and behavioral defects relevant to neurodevelopmental disorders, we generated global Ptchd...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49781-y
更新日期：2019-09-12 00:00:00
abstract：:Any processing delay between the two eyes can result in illusory 3D percepts for moving objects because of either changes in the pure disparities over time for disparity sensors or by changes to sensors that encode motion/disparity conjointly. This is demonstrated by viewing a fronto-parallel pendulum through a neutra...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-06151-w
更新日期：2017-07-17 00:00:00
abstract：:Nanoliposomal formulation of C6-ceramide, a proapoptotic sphingolipid metabolite, presents an effective way to treat malignant tumor. Here, we provide evidence that acute treatment (30 min) of melanoma and breast cancer cells with nanoliposomal C6-ceramide (NaL-C6) may suppress cell migration without inducing cell dea...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep09275
更新日期：2015-03-20 00:00:00
abstract：:Large (>10 kb) palindromic sequences are enriched on mammalian sex chromosomes. In mice, these palindromes harbor gene families (≥2 gene copies) expressed exclusively in post-meiotic testicular germ cells, a time when most single-copy sex-linked genes are transcriptionally repressed. This observation led to the hypoth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-27360-x
更新日期：2018-06-12 00:00:00
abstract：:Parental care is widespread in Archosaurs (birds, crocodilians, dinosaurs and pterosaurs), and this group provides a useful model for the evolution of parent-offspring interactions. While offspring signalling has been well-studied in birds, the modulation of parental care in crocodilians remains an open question. Here...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep15547
更新日期：2015-10-23 00:00:00
abstract：:We have experimentally demonstrated a strong correlation between the electrical properties of Zn1-xTex Ovonic threshold switching (OTS) selector device and the material properties analysed by X-ray diffraction (XRD), spectroscopic ellipsometry, and X-ray photoelectron spectroscopy (XPS). The correlation and the key ma...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-30207-0
更新日期：2018-08-07 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-18751-7
更新日期：2018-01-08 00:00:00
abstract：:A previous study identified 3 nonsynonymous and 6 synonymous mutations in the entire mosquito sodium channel of Culex quinquefasciatus, the prevalence of which were strongly correlated with levels of resistance and increased dramatically following insecticide selection. However, it is unclear whether this is unique to...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00781
更新日期：2012-01-01 00:00:00
abstract：:Gene expression profiles reflect the biologically diverse activities of cells under specific cell environments. Using the transcriptional response of cultured cells to blood composition, we developed a litmus gene assay to discriminate blood samples reflecting different sample qualities or disease conditions. This cel...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17293-2
更新日期：2017-12-04 00:00:00
abstract：:Craniosynostosis must often be corrected using surgery, by which the affected bone tissue is remodeled. Nowadays, surgical reconstruction relies mostly on the subjective judgement of the surgeon to best restore normal skull shape, since remodeled bone is manually placed and fixed. Slight variations can compromise the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54148-4
更新日期：2019-11-27 00:00:00
abstract：:Perovskite solar cells based on series of inorganic cesium lead bromide and iodide mixture, CsPbBr3-xI x , where x varies between 0, 0.1, 0.2, and 0.3 molar ratio were synthesized by two step-sequential deposition at ambient condition to design the variations of wide band gap light absorbers. A device with high overal...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-20228-0
更新日期：2018-02-06 00:00:00
abstract：:Urban water supplies are critical to the growth of the city and the wellbeing of its citizens. However, these supplies can be vulnerable to hydrological extremes, such as droughts and floods, especially if they are the main source of water for the city. Maintaining these supplies and preparing for future conditions is...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-23509-w
更新日期：2018-03-26 00:00:00
abstract：:Tyrosine hydroxylase (TH) catalyzes the hydroxylation of L-tyrosine to L-DOPA. This is the rate-limiting step in the biosynthesis of the catecholamines - dopamine (DA), norepinephrine (NE), and epinephrine (EP). Catecholamines (CA) play a key role as neurotransmitters and hormones. Aberrant levels of CA are associated...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-54461-y
更新日期：2019-12-09 00:00:00
abstract：:The chorioallantoic-membrane (CAM)-assay is an established model for in vivo tumor research. Contrary to rodent-xenograft-models, the CAM-assay does not require breeding of immunodeficient strains due to native immunodeficiency. This allows xenografts to grow on the non-innervated CAM without pain or impairment for th...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75660-y
更新日期：2020-10-29 00:00:00
abstract：:Nanoporous structures have proven as an effective way for enhanced electrochromic performance by providing a large surface area can get fast ion/electron transfer path, leading to larger optical modulation and fast response time. Herein, for the first time, application of vacuum cathodic arc plasma (CAP) deposition te...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-65191-x
更新日期：2020-05-21 00:00:00
abstract：:Carbon-based stationary phases for chromatographic separation have been commercially available since the 1980s. Porous graphitic carbon liquid chromatography columns are known to be highly resistant to aggressive mobile phases and extreme pH values of solvents and eluents, an important advantage compared to convention...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-33075-w
更新日期：2018-10-03 00:00:00
abstract：:Single-nucleotide polymorphisms (SNPs) in cytokine genes can affect gene expression and thereby modulate inflammation and carcinogenesis. However, the data on the association between SNPs in the interleukin 1 beta gene (IL1B) and colorectal cancer (CRC) are conflicting. We found an association between a 4-SNP haplotyp...
journal_title：Scientific reports
pub_type： 杂志文章,多中心研究
doi：10.1038/srep41920
更新日期：2017-02-03 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-020-77348-9
更新日期：2020-11-18 00:00:00
abstract：:Sex hormones may have a role in the pathophysiology of substance use disorders, as demonstrated by the association between testosterone and addictive behaviour in opioid dependence. Although opioid use has been found to suppress testosterone levels in men and women, the extent of this effect and how it relates to meth...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep06189
更新日期：2014-08-26 00:00:00
abstract：:Neuroblastoma is the most commonly diagnosed extracranial tumor in the first year of life. Approximately 9% of neuroblastoma patients present germline or somatic aberrations in the gene encoding for anaplastic lymphoma kinase (ALK). This increases in high-risk neuroblastomas, which have a 14% frequency of ALK aberrati...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55060-7
更新日期：2019-12-18 00:00:00
abstract：:Coronary computed tomography angiography is an established technique in clinical practice and a valuable tool in the diagnosis of coronary artery disease in humans. Imaging of coronaries in preclinical research, i.e. in small animals, is very difficult due to the high demands on spatial and temporal resolution. Mice e...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-73735-4
更新日期：2020-10-08 00:00:00
abstract：:Sonic hedgehog (Shh) is a multifunctional signaling protein governing pattern formation, proliferation and cell survival during embryogenesis. In the adult brain, Shh has neurotrophic function and is implicated in hippocampal neurogenesis but the cellular source of Shh in the hippocampus remains ill defined. Here, we ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53192-4
更新日期：2019-11-22 00:00:00
abstract：:The gliotransmitter glutamate released from astrocytes can modulate neuronal firing by activating neuronal N-methyl-D-aspartic acid (NMDA) receptors. This enables astrocytic glutamate(AG) to be involved in neuronal physiological and pathological functions. Based on empirical results and classical neuron-glial "tripart...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32343
更新日期：2016-08-30 00:00:00
abstract：:A marine isolate, Nesiotobacter exalbescens COD22, isolated from deep sea sediment (2100 m depth) was capable of degrading aromatic hydrocarbons. The Nesiotobacter sp. grew well in the presence of toluene at 0.1 MPa and 10 MPa at a rate of 0.24 h-1 and 0.12 h-1, respectively, in custom designed high pressure reactors....
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-55115-9
更新日期：2019-12-10 00:00:00
abstract：:During chronic cerebral hypoperfusion (CCH), the cerebral blood flow gradually decreases, leading to cognitive impairments and neurodegenerative disorders, such as vascular dementia. The reduced oxygenation, energy supply induced metabolic changes, and insufficient neuroplasticity could be reflected in the synaptic pr...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-72868-w
更新日期：2020-09-29 00:00:00
abstract：:Studies of past human-landscape interactions rely upon the integration of archaeological, biological and geological information within their geographical context. However, detecting the often ephemeral traces of human activities at a landscape scale remains difficult with conventional archaeological field survey. Geop...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep01517
更新日期：2013-01-01 00:00:00
abstract：:Numerous studies have been conducted to examine the molecular mechanism of Haemophilus parasuis resistance to antibiotic, but rarely to tildipirosin. In the current study, transcriptional profiling was applied to analyse the variation in gene expression of JS0135 and tildipirosin-resistant JS32. The growth curves show...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07972-5
更新日期：2017-08-08 00:00:00
abstract：:Globally, lung cancer accounts for approximately 20% of all cancer related deaths. Five-year survival is poor and rates have remained unchanged for the past four decades. There is an urgent need to identify markers of lung carcinogenesis and new targets for therapy. Given the recent successes of immune modulators in c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep18907
更新日期：2016-01-13 00:00:00
abstract：:Our study aimed to compare the ability of anthropometric obesity indices to predict MetS and to determine the sex-specific optimal cut-off values for MetS among Malaysian vegetarians. Body weight, height, waist circumference (WC), blood pressure (BP), fasting venous blood sample were collected from 273 vegetarians in ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78035-5
更新日期：2020-11-30 00:00:00
