Oral Agents for the Treatment of Gestational Diabetes.

Abstract:

PURPOSE OF REVIEW:To review the current evidence of the safety and efficacy of the use of oral agents for treatment of gestational diabetes (GDM). RECENT FINDINGS:The use of metformin and glyburide in pregnancy for treatment of GDM has dramatically increased since the early 2000s. Meta-analyses suggest that glyburide may increase the risk for large for gestational (LGA) infants and neonatal hypoglycemia. Conversely, metformin may potentially decrease rates of pregnancy-induced hypertension, LGA, neonatal hypoglycemia, and maternal weight gain. However, recent long-term offspring studies indicate a potential detrimental effect of metformin on fat mass that suggests an effect of such medication on fetal programming. While there have been several novel oral anti-diabetes medications brought to market in the past decade, there is minimal data to guide use and in particular data regarding long-term safety for the exposed offspring of treated women. Most professional societies recommend insulin as first-line treatment of gestational diabetes after failure of lifestyle modification. Both metformin and glyburide cross the placenta and long-term safety data is limited. However, patient satisfaction is substantially higher with use of oral agents, and the current literatures suggest that metformin may reduce several common short-term adverse outcomes related to GDM.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Finneran MM,Landon MB

doi

10.1007/s11892-018-1093-2

subject

Has Abstract

pub_date

2018-09-28 00:00:00

pages

119

issue

11

eissn

1534-4827

issn

1539-0829

pii

10.1007/s11892-018-1093-2

journal_volume

18

pub_type

杂志文章,评审
  • Possible role of GLP-1 and its agonists in the treatment of type 1 diabetes mellitus.

    abstract::Unfortunately, the only approved medical treatment for type 1 diabetes mellitus (DM) is insulin, despite the fact that tight control cannot be reached without some serious side effects such as hypoglycemia and weight gain. More and more importance is now shifted towards developing new drugs that can reach a better gly...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-012-0291-6

    authors: Issa CM,Azar ST

    更新日期:2012-10-01 00:00:00

  • Interventions to Improve Rate of Diabetes Testing Postpartum in Women With Gestational Diabetes Mellitus.

    abstract:PURPOSE OF REVIEW:Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. In the USA, four million women are screened annually for GDM in pregnancy in part to improve pregnancy outcomes but also because diagnosis predicts a high risk of future type 2 diabetes mellitus (T2DM). T...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-017-0835-x

    authors: Hamel MS,Werner EF

    更新日期:2017-02-01 00:00:00

  • Is there a relationship between oral health and diabetic neuropathy?

    abstract::Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0673-7

    authors: Borgnakke WS,Anderson PF,Shannon C,Jivanescu A

    更新日期:2015-11-01 00:00:00

  • No islets left behind: islet autotransplantation for surgery-induced diabetes.

    abstract::For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preser...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-012-0296-1

    authors: Bellin MD,Balamurugan AN,Pruett TL,Sutherland DE

    更新日期:2012-10-01 00:00:00

  • Transplantation of xenogeneic islets: are we there yet?

    abstract::Beta cell replacement therapy has been proposed as a novel therapy for the treatment of type 1 diabetes. The proof of concept has been demonstrated with successful islet allotransplantation. Islet xenotransplantation has been proposed as an alternative, more reliable, and infinite source of beta cells. The advantages ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0413-9

    authors: O'Connell PJ,Cowan PJ,Hawthorne WJ,Yi S,Lew AM

    更新日期:2013-10-01 00:00:00

  • Updates in Gestational Diabetes Prevalence, Treatment, and Health Policy.

    abstract:PURPOSE OF REVIEW:Gestational diabetes (GDM) is associated with adverse pregnancy and neonatal outcomes and increased maternal risk for subsequent type 2 diabetes. The best diagnostic strategy for GDM is debated and the role of oral antidiabetic medications (OAD) for treatment is unclear. In this paper, we review metho...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1147-0

    authors: Dickens LT,Thomas CC

    更新日期:2019-05-09 00:00:00

  • Sitting Less and Moving More: Improved Glycaemic Control for Type 2 Diabetes Prevention and Management.

    abstract::Epidemiological evidence indicates that excessive time spent in sedentary behaviours (too much sitting) is associated with an increased risk of type 2 diabetes (T2D). Here, we highlight findings of experimental studies corroborating and extending the epidemiological evidence and showing the potential benefits for T2D ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0797-4

    authors: Dempsey PC,Owen N,Yates TE,Kingwell BA,Dunstan DW

    更新日期:2016-11-01 00:00:00

  • PPAR-gamma agonists and diabetic nephropathy.

    abstract::Diabetic nephropathy is a clinical syndrome of albuminuria, declining glomerular filtration rate, and increased risk of cardiovascular disease. Multiple mechanisms have been implicated in its pathogenesis. Although current therapies appear to be effective, treatment of diabetic nephropathy remains suboptimal. This rev...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-005-0057-5

    authors: Zhang Y,Guan Y

    更新日期:2005-12-01 00:00:00

  • Oxidative stress: changes in pregnancy and with gestational diabetes mellitus.

    abstract::Pregnancy is susceptible to oxidative stress and antioxidant defenses can be altered in response to elevated levels of oxidative stress. Limited data in gestational diabetes mellitus (GDM) suggest that products of lipid peroxidation may be increased and antioxidant enzyme activities decreased, although the results hav...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-005-0024-1

    authors: Chen X,Scholl TO

    更新日期:2005-08-01 00:00:00

  • Automated analysis of diabetic retinopathy images: principles, recent developments, and emerging trends.

    abstract::Diabetic retinopathy (DR) is a vision-threatening complication of diabetes. Timely diagnosis and intervention are essential for treatment that reduces the risk of vision loss. A good color retinal (fundus) photograph can be used as a surrogate for face-to-face evaluation of DR. The use of computers to assist or fully ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0393-9

    authors: Li B,Li HK

    更新日期:2013-08-01 00:00:00

  • Integrated Cardio-Respiratory Control: Insight in Diabetes.

    abstract::Autonomic dysfunction is a frequent and relevant complication of diabetes mellitus, as it is associated with increased morbidity and mortality. In addition, it is today considered as predictive of the most severe diabetic complications, like nephropathy and retinopathy. The classical methods of screening are the cardi...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0804-9

    authors: Bernardi L,Bianchi L

    更新日期:2016-11-01 00:00:00

  • Role of Senescent Renal Cells in Pathophysiology of Diabetic Kidney Disease.

    abstract:PURPOSE OF REVIEW:Diabetic kidney disease (DKD) is the leading cause of kidney failure in the USA, representing ~ 44% of all cases of kidney failure. Advancements in both glucose management and inhibitors of the renin-angiotensin system have significantly improved prognosis for individuals with DKD, yet DKD continues t...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01314-y

    authors: Wiley CD

    更新日期:2020-06-16 00:00:00

  • FTO and obesity: mechanisms of association.

    abstract::The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gene are associated no...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-014-0486-0

    authors: Zhao X,Yang Y,Sun BF,Zhao YL,Yang YG

    更新日期:2014-01-01 00:00:00

  • Risks, benefits, and therapeutic potential of hematopoietic stem cell transplantation for autoimmune diabetes.

    abstract::Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing β cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory regimens were tested aiming at blocking some steps of the autoimmune process against β cell mass and ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-012-0309-0

    authors: Couri CE,de Oliveira MC,Simões BP

    更新日期:2012-10-01 00:00:00

  • Memory T Cells in Type 1 Diabetes: the Devil is in the Detail.

    abstract:PURPOSE OF REVIEW:Therapies that target beta-cell antigen-specific T cells subsets have not been as successful in patients with type 1 diabetes as in mice. This might be explained by complexities in the repertoire of beta-cell antigen-specific T cells and the variety of T cell subsets involved in type 1 diabetes develo...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-017-0889-9

    authors: Narsale A,Davies JD

    更新日期:2017-08-01 00:00:00

  • Sodium-Glucose Cotransporter Type 2 (SGLT-2) Inhibitors and Ketogenesis: the Good and the Bad.

    abstract:PURPOSE OF REVIEW:The micro/macrovascular complications of diabetes cause considerable morbidity and premature mortality. The SGLT2 inhibitors are the first diabetes medications with significant benefits on microvascular disease (nephropathy) and macrovascular cardiovascular disease. In this review, we evaluate one of ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01359-z

    authors: Ekanayake P,Hupfeld C,Mudaliar S

    更新日期:2020-11-23 00:00:00

  • CNS Regulation of Glucose Homeostasis: Role of the Leptin-Melanocortin System.

    abstract:PURPOSE OF REVIEW:In this brief review, we highlight studies that have contributed to our current understanding of glucose homeostasis by the central nervous system (CNS) leptin-melanocortin system, particularly proopiomelanocortin neurons and melanocortin-4 receptors (MC4R). RECENT FINDINGS:Leptin deficiency is assoc...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01311-1

    authors: da Silva AA,do Carmo JM,Hall JE

    更新日期:2020-05-26 00:00:00

  • Diagnosis, screening, and management of cystic fibrosis-related diabetes.

    abstract::Diabetes is a common complication of cystic fibrosis (CF), occurring in approximately 40% of adult patients. It is clinically distinct from type 1 or type 2 diabetes, and requires a unique approach. Because of evidence that it is associated with increased morbidity and mortality, prompt diagnosis and aggressive manage...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-002-0069-3

    authors: Moran A

    更新日期:2002-04-01 00:00:00

  • Vascular calcification in diabetes: mechanisms and implications.

    abstract::Cardiovascular disease (CVD) remains the leading cause of death among adults with diabetes, and CVD prevention remains a major challenge. Coronary artery calcium (CAC) score measured by electron beam tomography (EBT) or multi-slice detector computed tomography correlates closely with plaque burden and coronary angiogr...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0379-7

    authors: Snell-Bergeon JK,Budoff MJ,Hokanson JE

    更新日期:2013-06-01 00:00:00

  • Benefit-to-Risk Balance of Weight Loss Interventions in Older Adults with Obesity.

    abstract:PURPOSE OF REVIEW:Obesity in the older adult is a burgeoning health epidemic that leads to increased morbidity, disability, and institutionalization. This review presents a brief overview of geriatric-specific consequences of obesity by highlighting the risks and benefits of intentional weight loss. RECENT FINDINGS:In...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1249-8

    authors: DiMilia PR,Mittman AC,Batsis JA

    更新日期:2019-11-04 00:00:00

  • Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders.

    abstract:PURPOSE OF REVIEW:The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown whether this treatment is also suitable for patients with obesity due to a co...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01327-7

    authors: Vos N,Oussaada SM,Cooiman MI,Kleinendorst L,Ter Horst KW,Hazebroek EJ,Romijn JA,Serlie MJ,Mannens MMAM,van Haelst MM

    更新日期:2020-07-30 00:00:00

  • Heterogeneity in Obesity: Genetic Basis and Metabolic Consequences.

    abstract:PURPOSE OF REVIEW:Our review provides a brief summary of the most recent advances towards the identification of the genetic basis of specific aspects of obesity and the quantification of their consequences on health. We also highlight the most promising avenues to be explored in the future. RECENT FINDINGS:While obesi...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-1285-4

    authors: Sulc J,Winkler TW,Heid IM,Kutalik Z

    更新日期:2020-01-22 00:00:00

  • Cardiac autoimmunity as a novel biomarker, mediator, and therapeutic target of heart disease in type 1 diabetes.

    abstract::Patients with type 1 diabetes (T1D) suffer excess mortality from cardiovascular disease (CVD) that has persisted despite substantial reductions in microvascular complications. Although T1D and type 2 diabetes (T2D) are etiologically distinct, it has generally been assumed that CVD in T1D is "the same disease" as that ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0598-1

    authors: Lipes MA,Galderisi A

    更新日期:2015-05-01 00:00:00

  • Latent (slowly progressing) autoimmune diabetes in adults.

    abstract::About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and m...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-008-0018-x

    authors: Seissler J

    更新日期:2008-04-01 00:00:00

  • Maternal factors that determine neonatal size and body fat.

    abstract::These data are a review of previously published data. Initially, body composition was estimated in 186 neonates. Fat- free mass (FFM), which constituted 86% of birth weight, accounted for 83% of the variance in birth weight; fat mass (FM), which constituted 14% of birth weight, accounted for 46% of the variance in bir...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-001-0013-y

    authors: Catalano PM,Kirwan JP

    更新日期:2001-08-01 00:00:00

  • Multifocal electroretinography in diabetic retinopathy and diabetic macular edema.

    abstract::In this review article, we first present a brief overview of the vascular and neural components of diabetic retinopathy. Next, the multifocal electroretinogram (mfERG) technique, which can map neuroretinal function noninvasively, is described. Findings in diabetic retinal disease using the mfERG are reviewed. We then ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-014-0526-9

    authors: Bearse MA Jr,Ozawa GY

    更新日期:2014-01-01 00:00:00

  • Insights into the genetic susceptibility to type 2 diabetes from genome-wide association studies of glycaemic traits.

    abstract::Over the past 8 years, the genetics of complex traits have benefited from an unprecedented advancement in the identification of common variant loci for diseases such as type 2 diabetes (T2D). The ability to undertake genome-wide association studies in large population-based samples for quantitative glycaemic traits ha...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-014-0551-8

    authors: Marullo L,El-Sayed Moustafa JS,Prokopenko I

    更新日期:2014-01-01 00:00:00

  • Nutrition and nonalcoholic fatty liver disease in children.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease found in 3% to 9% of children in the United States. NAFLD represents a spectrum of liver disease and is frequently associated with features of the metabolic syndrome. Nutrition's role in NAFLD is complex. It does not appear that overweight...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-008-0069-z

    authors: Vos MB,McClain CJ

    更新日期:2008-10-01 00:00:00

  • Assessing Psychological Insulin Resistance in Type 2 Diabetes: a Critical Comparison of Measures.

    abstract:PURPOSE OF REVIEW:This study aims to examine the operationalisation of 'psychological insulin resistance' (PIR) among people with type 2 diabetes and to identify and critique relevant measures. RECENT FINDINGS:PIR has been operationalised as (1) the assessment of attitudes or beliefs about insulin therapy and (2) hypo...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-017-0873-4

    authors: Holmes-Truscott E,Pouwer F,Speight J

    更新日期:2017-07-01 00:00:00

  • The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy.

    abstract:PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1243-1

    authors: Blair RA,Rosenberg EA,Palermo NE

    更新日期:2019-12-06 00:00:00