Euglycemic Ketoacidosis.

Abstract:

PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyperglycemia can delay diagnosis and treatment, resulting in potential serious adverse outcomes. RECENT FINDINGS:Recently, with the wide clinical use of sodium glucose co-transporter 2 inhibitors (SGLT2i), euKA has come back into the spotlight. Use of SGLT2i use can predispose to the development of ketoacidosis with relatively low or normal levels of blood glucose. This condition, however, can occur, in the absence of diabetes, in settings such as pregnancy, restriction on caloric intake, glycogen storage diseases or defective gluconeogenesis (alcohol abuse or chronic liver disease), and cocaine abuse. euKA is a challenging diagnosis for most physicians who may be misled by the presence of normal glycemia or mild hyperglycemia. In this article, we review pathophysiology, etiologies, clinical presentation and the management of euKA.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Bonora BM,Avogaro A,Fadini GP

doi

10.1007/s11892-020-01307-x

subject

Has Abstract

pub_date

2020-05-19 00:00:00

pages

25

issue

7

eissn

1534-4827

issn

1539-0829

pii

10.1007/s11892-020-01307-x

journal_volume

20

pub_type

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