Abstract:
PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyperglycemia can delay diagnosis and treatment, resulting in potential serious adverse outcomes. RECENT FINDINGS:Recently, with the wide clinical use of sodium glucose co-transporter 2 inhibitors (SGLT2i), euKA has come back into the spotlight. Use of SGLT2i use can predispose to the development of ketoacidosis with relatively low or normal levels of blood glucose. This condition, however, can occur, in the absence of diabetes, in settings such as pregnancy, restriction on caloric intake, glycogen storage diseases or defective gluconeogenesis (alcohol abuse or chronic liver disease), and cocaine abuse. euKA is a challenging diagnosis for most physicians who may be misled by the presence of normal glycemia or mild hyperglycemia. In this article, we review pathophysiology, etiologies, clinical presentation and the management of euKA.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Bonora BM,Avogaro A,Fadini GPdoi
10.1007/s11892-020-01307-xsubject
Has Abstractpub_date
2020-05-19 00:00:00pages
25issue
7eissn
1534-4827issn
1539-0829pii
10.1007/s11892-020-01307-xjournal_volume
20pub_type
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