Abstract:
:Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are further exacerbated by the metabolic syndrome. The duration of diabetes and glycemic control may have an impact on the type and severity of cognitive impairment, but as yet we cannot predict who is at greatest risk of developing cognitive impairment. The pathophysiology of cognitive impairment is multifactorial, although dysfunction in each interconnecting pathway ultimately leads to discordance in metabolic signaling. The pathophysiology includes defects in insulin signaling, autonomic function, neuroinflammatory pathways, mitochondrial (Mt) metabolism, the sirtuin-peroxisome proliferator-activated receptor-gamma co-activator 1α (SIRT-PGC-1α) axis, and Tau signaling. Several promising therapies have been identified in pre-clinical studies, but remain to be validated in clinical trials.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Zilliox LA,Chadrasekaran K,Kwan JY,Russell JWdoi
10.1007/s11892-016-0775-xsubject
Has Abstractpub_date
2016-09-01 00:00:00pages
87issue
9eissn
1534-4827issn
1539-0829pii
10.1007/s11892-016-0775-xjournal_volume
16pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:Review innovations in health care financing promoting health system investments in addressing medical and social determinants of health (SDH) for patients with diabetes. RECENT FINDINGS:Particular payment models implemented in the public and private sectors increasingly offer flexibility in health ca...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1275-6
更新日期:2019-11-20 00:00:00
abstract::Recent evidence points to the crucial role of the central nervous system in controlling glucose homeostasis. Hypothalamic centers involved in the regulation of energy balance and endogenous glucose production constantly sense fuel availability by receiving and integrating inputs from circulating nutrients and hormones...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-006-0033-8
更新日期:2006-06-01 00:00:00
abstract::Neonatal hypoglycemia is an important consequence for the infant of the mother with diabetes. We have reviewed 24 published papers of various protocols for control of glucose in pregnant diabetic women during labor and delivery including our own published work. A relationship of maternal glucose during labor and neona...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0450-4
更新日期:2014-01-01 00:00:00
abstract::In normal physiology, glucagon from pancreatic alpha cells plays an important role in maintaining glucose homeostasis via its regulatory effect on hepatic glucose production. Patients with type 2 diabetes suffer from fasting and postprandial hyperglucagonemia, which stimulate hepatic glucose production and, thus, cont...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-014-0555-4
更新日期:2014-12-01 00:00:00
abstract:PURPOSE OF REVIEW:To provide an updated summary of discoveries made to date resulting from genome-wide association study (GWAS) and sequencing studies, and to discuss the latest loci added to the growing repertoire of genetic signals predisposing to type 1 diabetes (T1D). RECENT FINDINGS:Genetic studies have identifie...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1235-1
更新日期:2019-11-04 00:00:00
abstract::The treatment of painful diabetic polyneuropathy (PDPN) remains a major challenge. A number of reasons have made the guidelines on PDPN management of particular interest, including its high prevalence, health and socioeconomic impact, interdisciplinary nature and the need for updated evidence-based information to refi...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0287-2
更新日期:2012-08-01 00:00:00
abstract::Proliferative diabetic retinopathy (PDR), characterized by pathologic retinal angiogenesis, is a major cause of blindness in the USA and globally. Treatments targeting vascular endothelial growth factor (VEGF) have emerged as a beneficial part of the therapeutic armamentarium for this condition, highlighting the utili...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0289-0
更新日期:2012-08-01 00:00:00
abstract::As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0270-y
更新日期:2012-06-01 00:00:00
abstract::Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-010-0160-0
更新日期:2011-02-01 00:00:00
abstract::Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presenta...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-014-0538-5
更新日期:2014-10-01 00:00:00
abstract::Low- and middle-income countries (LMICs) face a rapid change in the nutrition transition toward increases in noncommunicable diseases. Underlying this transition are shifts in the agricultural system and the subsequent growth of the modern retail and food service sectors across all regions and countries, a change in t...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0631-4
更新日期:2015-09-01 00:00:00
abstract::Although there is clear evidence from experimental diabetic neuropathy (DN) models that the multiple pathways involved in neuronal degeneration cause overproduction of reactive oxygen species, oxidative stress, and cellular dysfunction, therapeutic approaches addressing these mechanisms have not yet provided a basis f...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-003-0007-z
更新日期:2003-12-01 00:00:00
abstract::Complementary and alternative medicine (CAM) describes a diverse group of medical and health care systems, practices, and products not currently considered to be part of conventional medicine. Inadequacies in current treatments for diabetes have led 2 to 3.6 million Americans to use CAM for diabetes treatment, despite...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-006-0042-7
更新日期:2006-06-01 00:00:00
abstract::Pregnancy is susceptible to oxidative stress and antioxidant defenses can be altered in response to elevated levels of oxidative stress. Limited data in gestational diabetes mellitus (GDM) suggest that products of lipid peroxidation may be increased and antioxidant enzyme activities decreased, although the results hav...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-005-0024-1
更新日期:2005-08-01 00:00:00
abstract::The transition from intravenous (IV) to subcutaneous (SQ) insulin in the hospitalized patient with diabetes or hyperglycemia is a key step in patient care. This review article suggests a stepwise approach to the transition in order to promote safety and euglycemia. Important components of the transition include evalua...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0595-4
更新日期:2015-05-01 00:00:00
abstract::Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0294-3
更新日期:2012-10-01 00:00:00
abstract::Diabetic nephropathy is the leading cause of renal failure in industrialized countries. There is strong evidence that diabetic nephropathy is influenced by genetic factors. Studies in the Pima Indians as well as in other populations demonstrate that diabetic nephropathy aggregates in families. The hypothesis that the ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-001-0046-2
更新日期:2001-12-01 00:00:00
abstract::Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for intervention....
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-001-0035-5
更新日期:2001-12-01 00:00:00
abstract:PURPOSE OF REVIEW:Neuropathic pain may arise from multiple mechanisms and locations. Efficacy of current treatments for painful diabetic neuropathy is limited to an unpredictable subset of patients, possibly reflecting diversity of pain generator mechanisms, and there is a lack of targeted treatments for individual pat...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-0969-5
更新日期:2018-01-23 00:00:00
abstract::A large body of evidence indicates that the risk for developing chronic diabetic complications is under the control of genetic factors. Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropath...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-010-0147-x
更新日期:2010-12-01 00:00:00
abstract::Diagnostic criteria for diabetes in children have not been established with nearly the rigor as that employed in adults. Recently revised American Diabetes Association (ADA) criteria allowed utilization of hemoglobin A(1c) (HbA1c) ≥ 6.5 % for diagnosis of diabetes. A recent series of pediatric studies appear to show t...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0343-y
更新日期:2013-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. RECENT FINDINGS:Generation of multi-omic data to measure each of the "biologic layers," developments in describing genomic function an...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1137-2
更新日期:2019-02-26 00:00:00
abstract:PURPOSE:The measurement and estimation of diabetes in populations guides resource allocation, health priorities, and can influence practice and future research. To provide a critical reflection on current diabetes surveillance, we provide in-depth discussion about how upstream determinants, prevalence, incidence, and d...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1088-z
更新日期:2018-09-19 00:00:00
abstract::Marijuana is used by millions of people, with use likely to increase in the USA because of the trend towards increased decriminalization and legalization. Obesity and diabetes mellitus (DM) rates have increased dramatically in the USA over the past 30 years, with a recent estimate of 29 million individuals with DM. Be...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0795-6
更新日期:2016-11-01 00:00:00
abstract:PURPOSE OF REVIEW:Therapies that target beta-cell antigen-specific T cells subsets have not been as successful in patients with type 1 diabetes as in mice. This might be explained by complexities in the repertoire of beta-cell antigen-specific T cells and the variety of T cell subsets involved in type 1 diabetes develo...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0889-9
更新日期:2017-08-01 00:00:00
abstract::Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus (DM). DM is now recognized as a risk equivalent for coronary heart disease. The lipid profile in patients with type 2 DM is characterized by elevated triglycerides, low levels of high-density lipoprotein cholest...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-007-0036-0
更新日期:2007-06-01 00:00:00
abstract::Hypertension and diabetes are independent risk factors for both cardiovascular disease and renal complications. Coexistence of these comorbid conditions predisposes the patient to a much greater risk of progression to end-stage renal disease. Combined with the increased cardiovascular mortality, this has led to recent...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-002-0124-0
更新日期:2002-12-01 00:00:00
abstract::Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and acti...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0605-6
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Obesity and its associated metabolic diseases have reached epidemic proportions worldwide, reducing life expectancy and quality of life. Several drugs have been tested to treat these diseases but many of them have damaging side effects. Consequently, there is an urgent need to develop more effective t...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0866-3
更新日期:2017-06-01 00:00:00
abstract::Exercise has long been recognized as a cornerstone in diabetes care. Even so, modern science is just beginning to understand the physiologic impact cardiovascular fitness has on long-term diabetes management, and the prevention or delay, of type 2 diabetes. Recent advances in research are defining the metabolic pathwa...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-002-0109-z
更新日期:2002-10-01 00:00:00