The forgotten role of glucose effectiveness in the regulation of glucose tolerance.

abstract：:Although numerous chemokine/chemokine receptor pathways have been described to be implicated in the pathogenesis of type 1 diabetes (T1D), the CXCR1/2 axis has recently been proved to be crucial for leucocyte recruitment involved in insulitis and β cell damage. Multiple strategies blocking the CXCR1/2 pathway are avai...

journal_title：Current diabetes reports

authors： Citro A,Cantarelli E,Piemonti L

更新日期：2015-10-01 00:00:00

abstract：:Overnutrition is a major cause of diabetes. The contrary situation of undernutrition has also been suggested to increase the risk of the disease. Especially undernutrition during prenatal life has been hypothesized to program the structure and physiology of the fetus in such a way that it is more prone to develop diab...

journal_title：Current diabetes reports

authors： de Rooij SR,Roseboom TJ,Painter RC

更新日期：2014-10-01 00:00:00

abstract：:The endothelium has several diverse functions in maintaining vascular integrity in terms of structure and function. Two key vasodilators, nitric oxide (NO) and prostacyclin, maintain the vascular pathway, inhibit platelet aggregation, and are antithrombotic. More recently, they have been shown to be anti-inflammatory,...

journal_title：Current diabetes reports

authors： Dandona P

更新日期：2002-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity is increasing at an alarming rate and now poses a global threat to humankind. In recent years, we have seen the emergence of medical devices to combat the obesity epidemic. These therapeutic strategies are discussed in this review dividing them into gastric and duodenal therapies. RECENT FIND...

journal_title：Current diabetes reports

authors： Ruban A,Doshi A,Lam E,Teare JP

更新日期：2019-08-30 00:00:00

abstract：:This article reviews selected recent literature on adult diabetes patient-centered adherence to diabetes care recommendations. We describe more fully a limited number of articles that have particular lessons for diabetes clinicians and researchers. Each article was reviewed for methodology, adherence measures, and typ...

journal_title：Current diabetes reports

authors： Walker EA,Usher JA

更新日期：2003-04-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to discuss the burden of type 2 diabetes in youth and summarize the studies that have utilized noninvasive techniques to assess early vascular disease in youth with type 2 diabetes. RECENT FINDINGS:Noninvasive imaging modalities provide researchers with tools to investigate the vascu...

journal_title：Current diabetes reports

authors： Shah AS,Urbina EM

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity in the older adult is a burgeoning health epidemic that leads to increased morbidity, disability, and institutionalization. This review presents a brief overview of geriatric-specific consequences of obesity by highlighting the risks and benefits of intentional weight loss. RECENT FINDINGS:In...

journal_title：Current diabetes reports

authors： DiMilia PR,Mittman AC,Batsis JA

更新日期：2019-11-04 00:00:00

abstract：PURPOSE OF REVIEW:Soon after the first genome-wide association study (GWAS) for type 2 diabetes (T2D) was published, it was hypothesized that rare and low-frequency variants might explain a substantial proportion of disease risk. Rare coding variants in particular were emphasized given their large expected role in dise...

journal_title：Current diabetes reports

authors： Flannick J

更新日期：2019-04-08 00:00:00

abstract：:Complementary and alternative medicine (CAM) describes a diverse group of medical and health care systems, practices, and products not currently considered to be part of conventional medicine. Inadequacies in current treatments for diabetes have led 2 to 3.6 million Americans to use CAM for diabetes treatment, despite...

journal_title：Current diabetes reports

authors： Dham S,Shah V,Hirsch S,Banerji MA

更新日期：2006-06-01 00:00:00

abstract：:About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and m...

journal_title：Current diabetes reports

authors： Seissler J

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity and diabetes are worldwide epidemics. There is also a growing body of evidence relating the gut microbiome composition to insulin resistance. The purpose of this review is to delineate the studies linking gut microbiota to obesity, metabolic syndrome, and diabetes. RECENT FINDINGS:Animal stud...

journal_title：Current diabetes reports

authors： Chen X,Devaraj S

更新日期：2018-10-18 00:00:00

abstract：PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...

journal_title：Current diabetes reports

authors： Blair RA,Rosenberg EA,Palermo NE

更新日期：2019-12-06 00:00:00

abstract：:Hyperglycemia and dyslipidemia are significant and independent risk factors for the vascular complications in patients with diabetes. They have been suggested to cause cardiovascular pathologic changes in diabetic states through the following molecular mechanisms: formation and accumulation of advanced glycation end p...

journal_title：Current diabetes reports

authors： Xu Y,He Z,King GL

更新日期：2005-04-01 00:00:00

abstract：:Type 1 and type 2 diabetes both accelerate cardiovascular disease, yet the triggers are likely different for the two types of diabetes. Results from large-scale clinical trials suggest that intense blood glucose control can reduce cardiovascular events many years later in patients with type 1 diabetes. In type 2 diabe...

journal_title：Current diabetes reports

authors： Averill MM,Bornfeldt KE

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the study is to examine and summarize studies reporting on the epidemiology, the risk of developing diabetes, and the cardiovascular effects on individuals with diabetes of different levels of alcohol consumption. RECENT FINDINGS:Men consume more alcohol than women in populations with ...

journal_title：Current diabetes reports

authors： Polsky S,Akturk HK

更新日期：2017-11-04 00:00:00

abstract：:The term prediabetes refers to subjects with impaired fasting glucose and/or impaired glucose tolerance who are at increased risk for type 2 diabetes mellitus. Although both types of patients are at increased risk for developing type 2 diabetes mellitus and cardiovascular disease, they manifest distinct metabolic abno...

journal_title：Current diabetes reports

authors： Abdul-Ghani MA,DeFronzo RA

更新日期：2009-06-01 00:00:00

abstract：:In normal physiology, glucagon from pancreatic alpha cells plays an important role in maintaining glucose homeostasis via its regulatory effect on hepatic glucose production. Patients with type 2 diabetes suffer from fasting and postprandial hyperglucagonemia, which stimulate hepatic glucose production and, thus, cont...

journal_title：Current diabetes reports

authors： Lund A,Bagger JI,Christensen M,Knop FK,Vilsbøll T

更新日期：2014-12-01 00:00:00

abstract：:Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are fur...

journal_title：Current diabetes reports

authors： Zilliox LA,Chadrasekaran K,Kwan JY,Russell JW

更新日期：2016-09-01 00:00:00

abstract：PURPOSE OF REVIEW:Review innovations in health care financing promoting health system investments in addressing medical and social determinants of health (SDH) for patients with diabetes. RECENT FINDINGS:Particular payment models implemented in the public and private sectors increasingly offer flexibility in health ca...

journal_title：Current diabetes reports

authors： Saulsberry L,Peek M

更新日期：2019-11-20 00:00:00

abstract：:Over the past 8 years, the genetics of complex traits have benefited from an unprecedented advancement in the identification of common variant loci for diseases such as type 2 diabetes (T2D). The ability to undertake genome-wide association studies in large population-based samples for quantitative glycaemic traits ha...

journal_title：Current diabetes reports

authors： Marullo L,El-Sayed Moustafa JS,Prokopenko I

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview of the current knowledge regarding the natural history of human type 1 diabetes (T1D) and the documented associations between virus infections (in particular the enteroviruses) and disease development. We review studies that examine whether T1D-specific risk alleles in genes inv...

journal_title：Current diabetes reports

authors： Blanter M,Sork H,Tuomela S,Flodström-Tullberg M

更新日期：2019-08-10 00:00:00

abstract：PURPOSE OF REVIEW:Diabetic nephropathy, a major microvascular complication of diabetes and the most common cause of end-stage renal disease, is characterized by prominent accumulation of extracellular matrix. The membrane microdomains caveolae, and their integral protein caveolin-1, play critical roles in the regulatio...

journal_title：Current diabetes reports

authors： Van Krieken R,Krepinsky JC

更新日期：2017-03-01 00:00:00

abstract：:For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preser...

journal_title：Current diabetes reports

authors： Bellin MD,Balamurugan AN,Pruett TL,Sutherland DE

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Diabetes is the leading cause of kidney disease globally. Diabetic kidney disease (DKD) is a heterogeneous disorder manifested as albuminuria and/or decreasing GFR. Hyperglycemic burden is the major contributor to the development of DKD. In this article, we review the evidence for the contribution of ...

journal_title：Current diabetes reports

authors： Subramanian S,Hirsch IB

更新日期：2018-02-15 00:00:00

abstract：:Recent studies support the concept that the retinal vasculature may provide a summary measure of lifetime exposure to the effects of hyperglycemia. Advances in retinal photographic techniques and in image analysis have allowed objective and precise in vivo measurement of retinal vascular changes. In particular, quanti...

journal_title：Current diabetes reports

authors： Nguyen TT,Wong TY

更新日期：2009-08-01 00:00:00

abstract：:The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of type 2 diabetes mellitus to the chromosome 1q21-25 region in at least eight independent studies. More than 26 candidate genes have already been evaluated, but to date none explain the evidence for linkage in this gene-dense region....

journal_title：Current diabetes reports

authors： Das SK,Elbein SC

更新日期：2007-04-01 00:00:00

abstract：:Lipodystrophies are a genetically heterogeneous group of disorders characterized by loss of subcutaneous adipose tissue and metabolic dysfunction, including insulin resistance, increased levels of free fatty acids, abnormal adipocytokine secretion, and ectopic fat deposition, which are also observed in patients with v...

journal_title：Current diabetes reports

authors： Ficarella R,Laviola L,Giorgino F

更新日期：2015-03-01 00:00:00

abstract：:Suboptimal glycemic control is more common among non-Hispanic Blacks (NHBs) and Hispanics than non-Hispanic Whites (NHWs). Disparities in the performance of self-care behaviors may contribute to this. To synthesize knowledge on current self-care disparities, we reviewed studies from January 2011-March 2016 that includ...

journal_title：Current diabetes reports

authors： Mayberry LS,Bergner EM,Chakkalakal RJ,Elasy TA,Osborn CY

更新日期：2016-11-01 00:00:00

abstract：:Mobile and smartphone (mHealth) technologies have the potential to improve diabetes care and self-management, but little is known about their effectiveness and how patients, providers, and payers currently interact with them. We conducted a systematic review and found only 20 peer-reviewed articles, published since 20...

journal_title：Current diabetes reports

authors： Garabedian LF,Ross-Degnan D,Wharam JF

更新日期：2015-12-01 00:00:00

abstract：:Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presenta...

journal_title：Current diabetes reports

authors： Lauria G,Ziegler D,Malik R,Merkies IS,Waxman SG,Faber CG,PROPANE Study group.

更新日期：2014-10-01 00:00:00