Introduction of hyperglycemia and dyslipidemia in the pathogenesis of diabetic vascular complications.

Abstract:

:Hyperglycemia and dyslipidemia are significant and independent risk factors for the vascular complications in patients with diabetes. They have been suggested to cause cardiovascular pathologic changes in diabetic states through the following molecular mechanisms: formation and accumulation of advanced glycation end products; increased oxidative stress; activation of protein kinase C pathway; increased activity of hexosamine pathway; and vascular inflammation and the impairment of insulin action in the vascular tissues.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Xu Y,He Z,King GL

doi

10.1007/s11892-005-0034-z

keywords:

subject

Has Abstract

pub_date

2005-04-01 00:00:00

pages

91-7

issue

2

eissn

1534-4827

issn

1539-0829

journal_volume

5

pub_type

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