Abstract:
:Overnutrition is a major cause of diabetes. The contrary situation of undernutrition has also been suggested to increase the risk of the disease. Especially undernutrition during prenatal life has been hypothesized to program the structure and physiology of the fetus in such a way that it is more prone to develop diabetes in later life. Famines over the last 100 years have provided historical opportunities to study later-life health consequences of poor nutritional circumstances in early life. The majority of studies based on famine exposure during prenatal life clearly show that diabetes risk is increased. Postnatal famine exposure in childhood, adolescence, or young adulthood also seems to raise risk for diabetes, although prenatal famine effects seem to be more substantial. These study results not only have implications for the consequences of famines still happening but also for pregnancies complicated by factors mimicking poor nutritional situations.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
de Rooij SR,Roseboom TJ,Painter RCdoi
10.1007/s11892-014-0536-7subject
Has Abstractpub_date
2014-10-01 00:00:00pages
536issue
10eissn
1534-4827issn
1539-0829journal_volume
14pub_type
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