Famines in the last 100 years: implications for diabetes.

Abstract:

:Overnutrition is a major cause of diabetes. The contrary situation of undernutrition has also been suggested to increase the risk of the disease. Especially undernutrition during prenatal life has been hypothesized to program the structure and physiology of the fetus in such a way that it is more prone to develop diabetes in later life. Famines over the last 100 years have provided historical opportunities to study later-life health consequences of poor nutritional circumstances in early life. The majority of studies based on famine exposure during prenatal life clearly show that diabetes risk is increased. Postnatal famine exposure in childhood, adolescence, or young adulthood also seems to raise risk for diabetes, although prenatal famine effects seem to be more substantial. These study results not only have implications for the consequences of famines still happening but also for pregnancies complicated by factors mimicking poor nutritional situations.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

de Rooij SR,Roseboom TJ,Painter RC

doi

10.1007/s11892-014-0536-7

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

536

issue

10

eissn

1534-4827

issn

1539-0829

journal_volume

14

pub_type

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