Abstract:
PURPOSE OF REVIEW:The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown whether this treatment is also suitable for patients with obesity due to a confirmed genetic defect (genetic obesity disorders). Therefore, this review aims to elucidate the role of bariatric surgery in the treatment of genetic obesity. RECENT FINDINGS:In monogenic non-syndromic obesity, an underlying genetic defect seems to be the most important factor determining the efficacy of bariatric surgery. In syndromic obesity, bariatric surgery result data are scarce, and even though some promising follow-up results have been reported, caution is required as patients with more severe behavioral and developmental disorders might have poorer outcomes. There is limited evidence in support of bariatric surgery as a treatment option for genetic obesity disorders; hence, no strong statements can be made regarding the efficacy and safety of these procedures for these patients. However, considering that patients with genetic obesity often present with life-threatening obesity-related comorbidities, we believe that bariatric surgery could be considered a last-resort treatment option in selected patients.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Vos N,Oussaada SM,Cooiman MI,Kleinendorst L,Ter Horst KW,Hazebroek EJ,Romijn JA,Serlie MJ,Mannens MMAM,van Haelst MMdoi
10.1007/s11892-020-01327-7subject
Has Abstractpub_date
2020-07-30 00:00:00pages
44issue
9eissn
1534-4827issn
1539-0829pii
10.1007/s11892-020-01327-7journal_volume
20pub_type
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pub_type: 杂志文章,评审
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