Abstract:
:Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous system where mitochondrial dysfunction has been implicated as an etiological factor. Diabetes (type 1 or type 2) invokes an elevation of intracellular glucose concentration simultaneously with impaired growth factor support by insulin, and this dual alteration triggers a maladaptation in metabolism of adult sensory neurons. The energy sensing pathway comprising the AMP-activated protein kinase (AMPK)/sirtuin (SIRT)/peroxisome proliferator-activated receptor-γ coactivator α (PGC-1α) signaling axis is the target of these damaging changes in nutrient levels, e.g., induction of nutrient stress, and loss of insulin-dependent growth factor support and instigates an aberrant metabolic phenotype characterized by a suppression of mitochondrial oxidative phosphorylation and shift to anaerobic glycolysis. There is discussion of how this loss of mitochondrial function and transition to overreliance on glycolysis contributes to the diminishment of collateral sprouting and axon regeneration in diabetic neuropathy in the context of the highly energy-consuming nerve growth cone.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Fernyhough Pdoi
10.1007/s11892-015-0671-9subject
Has Abstractpub_date
2015-11-01 00:00:00pages
89issue
11eissn
1534-4827issn
1539-0829pii
10.1007/s11892-015-0671-9journal_volume
15pub_type
杂志文章,评审abstract::The insulin resistance syndrome (IRS) is a common disorder, which has important clinical implications. It is a cluster of cardiovascular risk factors that include obesity, hypertension, dyslipidemia, glucose intolerance, and type 2 diabetes mellitus. Lifestyle modifications and insulin sensitizers are among the severa...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-001-0026-6
更新日期:2001-10-01 00:00:00
abstract::Among the factors predisposing to type 2 diabetes in children, adolescents, and young adults, the health and behavior of both the mother and father are critical. Prevention and treatment of parental nutritional disorders (including obesity and malnutrition), promotion of breastfeeding, and avoidance of overfeeding of ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-011-0246-3
更新日期:2012-02-01 00:00:00
abstract::Patients with type 1 diabetes (T1D) suffer excess mortality from cardiovascular disease (CVD) that has persisted despite substantial reductions in microvascular complications. Although T1D and type 2 diabetes (T2D) are etiologically distinct, it has generally been assumed that CVD in T1D is "the same disease" as that ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0598-1
更新日期:2015-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Type 2 diabetes is common, burdensome, and preventable. Landmark trials such as the Diabetes Prevention Program (DPP) demonstrated that resource-intensive lifestyle support interventions resulting in modest weight loss via healthy diet changes and physical activity can lower the rate of diabetes devel...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-1293-4
更新日期:2020-02-20 00:00:00
abstract::Metabolomics is the snapshot of all detectable metabolites and lipids in biological materials and has potential in reflecting genetic and environmental factors contributing to the development of complex diseases, such as type 1 diabetes. The progression to seroconversion to development of type 1 diabetes has been stud...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0820-9
更新日期:2016-12-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this review is to provide updates on congenital (neonatal) diabetes from 2011 to present, with an emphasis on publications from 2015 to present. RECENT FINDINGS:There has been continued worldwide progress in uncovering the genetic causes of diabetes presenting within the first year of lif...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1016-2
更新日期:2018-06-13 00:00:00
abstract::Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-004-0037-1
更新日期:2004-10-01 00:00:00
abstract::Cardiovascular disease (CVD) remains the leading cause of death among adults with diabetes, and CVD prevention remains a major challenge. Coronary artery calcium (CAC) score measured by electron beam tomography (EBT) or multi-slice detector computed tomography correlates closely with plaque burden and coronary angiogr...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0379-7
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyper...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01307-x
更新日期:2020-05-19 00:00:00
abstract::The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gene are associated no...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-014-0486-0
更新日期:2014-01-01 00:00:00
abstract::Exercise has long been recognized as a cornerstone in diabetes care. Even so, modern science is just beginning to understand the physiologic impact cardiovascular fitness has on long-term diabetes management, and the prevention or delay, of type 2 diabetes. Recent advances in research are defining the metabolic pathwa...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-002-0109-z
更新日期:2002-10-01 00:00:00
abstract::Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0294-3
更新日期:2012-10-01 00:00:00
abstract::Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for intervention....
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-001-0035-5
更新日期:2001-12-01 00:00:00
abstract::About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and m...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-008-0018-x
更新日期:2008-04-01 00:00:00
abstract::Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing β cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory regimens were tested aiming at blocking some steps of the autoimmune process against β cell mass and ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0309-0
更新日期:2012-10-01 00:00:00
abstract::Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and acti...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0605-6
更新日期:2015-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This study aims to examine the operationalisation of 'psychological insulin resistance' (PIR) among people with type 2 diabetes and to identify and critique relevant measures. RECENT FINDINGS:PIR has been operationalised as (1) the assessment of attitudes or beliefs about insulin therapy and (2) hypo...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0873-4
更新日期:2017-07-01 00:00:00
abstract::Mobile and smartphone (mHealth) technologies have the potential to improve diabetes care and self-management, but little is known about their effectiveness and how patients, providers, and payers currently interact with them. We conducted a systematic review and found only 20 peer-reviewed articles, published since 20...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0680-8
更新日期:2015-12-01 00:00:00
abstract::Diabetic polyneuropathy (DPN) is the most common complication that emerges early in patients who have diabetes. Curative treatment for overt or symptomatic DPN has not been established, requiring much effort to explore new modalities. Thus, the use of various kinds of stem cells as a potential therapeutic option for D...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0776-9
更新日期:2016-09-01 00:00:00
abstract::Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectiv...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0364-1
更新日期:2013-04-01 00:00:00
abstract::Suspicion that fructose-containing caloric sweeteners (FCCS) may play a causal role in the development of metabolic diseases has elicited intense basic and clinical research over the past 10 years. Prospective cohort studies converge to indicate that FCCS, and more specifically sugar-sweetened beverages (SSBs), consum...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0627-0
更新日期:2015-08-01 00:00:00
abstract::Pharmacologic doses of glucocorticoids and chronic renal failure are challenging comorbidities and complications for safe and effective dosing of insulin for the management of hospitalized patients with diabetes. Glucocorticoids are used widely in hospitalized patients and will commonly provoke new-onset hyperglycemia...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0339-7
更新日期:2013-02-01 00:00:00
abstract::Replacing dysfunctional endocrine tissues (eg, islets) with healthy, nonautologous material protected against the immune defense of the patient could soon become a reality. Recent advances have resulted in the development of alginate-based microcapsules that meet the demands of biocompatibility, long-term integrity, a...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-007-0051-1
更新日期:2007-08-01 00:00:00
abstract:PURPOSE OF REVIEW:In this brief review, we highlight studies that have contributed to our current understanding of glucose homeostasis by the central nervous system (CNS) leptin-melanocortin system, particularly proopiomelanocortin neurons and melanocortin-4 receptors (MC4R). RECENT FINDINGS:Leptin deficiency is assoc...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01311-1
更新日期:2020-05-26 00:00:00
abstract::In this review article, we first present a brief overview of the vascular and neural components of diabetic retinopathy. Next, the multifocal electroretinogram (mfERG) technique, which can map neuroretinal function noninvasively, is described. Findings in diabetic retinal disease using the mfERG are reviewed. We then ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-014-0526-9
更新日期:2014-01-01 00:00:00
abstract::Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease found in 3% to 9% of children in the United States. NAFLD represents a spectrum of liver disease and is frequently associated with features of the metabolic syndrome. Nutrition's role in NAFLD is complex. It does not appear that overweight...
journal_title:Current diabetes reports
pub_type: 杂志文章
doi:10.1007/s11892-008-0069-z
更新日期:2008-10-01 00:00:00
abstract::Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are fur...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0775-x
更新日期:2016-09-01 00:00:00
abstract:PURPOSE OF REVIEW:Soon after the first genome-wide association study (GWAS) for type 2 diabetes (T2D) was published, it was hypothesized that rare and low-frequency variants might explain a substantial proportion of disease risk. Rare coding variants in particular were emphasized given their large expected role in dise...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1142-5
更新日期:2019-04-08 00:00:00
abstract:PURPOSE OF REVIEW:The purpose of the study is to examine and summarize studies reporting on the epidemiology, the risk of developing diabetes, and the cardiovascular effects on individuals with diabetes of different levels of alcohol consumption. RECENT FINDINGS:Men consume more alcohol than women in populations with ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0950-8
更新日期:2017-11-04 00:00:00
abstract:PURPOSE OF REVIEW:The oral glucose tolerance test (OGTT) is used both in clinical practice and research to assess glucose tolerance. In addition, the OGTT is utilized for surrogate measures of insulin sensitivity and the insulin response to enteral glucose and has been widely applied in the evaluation of β-cell dysfunc...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1023-3
更新日期:2018-06-16 00:00:00