Pathophysiology of prediabetes.

abstract：PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...

journal_title：Current diabetes reports

authors： Blair RA,Rosenberg EA,Palermo NE

更新日期：2019-12-06 00:00:00

abstract：:The transition from intravenous (IV) to subcutaneous (SQ) insulin in the hospitalized patient with diabetes or hyperglycemia is a key step in patient care. This review article suggests a stepwise approach to the transition in order to promote safety and euglycemia. Important components of the transition include evalua...

journal_title：Current diabetes reports

authors： Kreider KE,Lien LF

更新日期：2015-05-01 00:00:00

abstract：:Worldwide increases in diabetes prevalence in the face of limited medical resources have prompted international interest in innovative healthcare delivery models. Project ECHO (Extension for Community Healthcare Outcomes) is a "telementoring" program which has been shown to increase capacity for complex disease manage...

journal_title：Current diabetes reports

authors： Bouchonville MF,Paul MM,Billings J,Kirk JB,Arora S

更新日期：2016-10-01 00:00:00

abstract：:Hyperglycemia is common following organ transplantation, regardless of the pre-transplant diabetes status. Transient post-transplant hyperglycemia and/or new-onset diabetes after transplantation (NODAT) are common and are associated with increased morbidity and mortality. NODAT and type 2 diabetes share similar charac...

journal_title：Current diabetes reports

authors： Galindo RJ,Wallia A

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity and diabetes are worldwide epidemics. There is also a growing body of evidence relating the gut microbiome composition to insulin resistance. The purpose of this review is to delineate the studies linking gut microbiota to obesity, metabolic syndrome, and diabetes. RECENT FINDINGS:Animal stud...

journal_title：Current diabetes reports

authors： Chen X,Devaraj S

更新日期：2018-10-18 00:00:00

abstract：:Contrast-induced nephropathy (CIN) continues to be a significant complication of the increasing use of iodinated contrast media. There have been few new insights into pathogenesis; despite multiple strategies aimed at prophylaxis, very few have proven efficacious. This article reviews our current knowledge regarding C...

journal_title：Current diabetes reports

authors： Solomon R

更新日期：2007-12-01 00:00:00

abstract：:Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...

journal_title：Current diabetes reports

authors： Durnwald CP,Landon MB

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Cont...

journal_title：Current diabetes reports

authors： Feldman MA,Anderson LM,Shapiro JB,Jedraszko AM,Evans M,Weil LEG,Garza KP,Weissberg-Benchell J

更新日期：2018-02-19 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the treatment of type 2 diabetes from a cardiologist's view. RECENT FINDINGS:A new era in the treatment of type 2 diabetes began for the cardiologist in 2015 with the publication of the EMPA-REG outcome trial finding a significant reduction in CV death with empagliflozin (oral sodium-gluc...

journal_title：Current diabetes reports

authors： Chilton RJ,Gallegos KM,Silva-Cardoso J,Oliveros R,Pham S

更新日期：2018-11-08 00:00:00

abstract：:Diabetic nephropathy is continuing to rise in incidence, despite awareness of tight glycemic control and blood pressure. The identification that matrix accumulation is driven by transforming growth factor-beta (TGF-beta) has led to a concerted effort to apply antifibrotic strategies for this disorder. Recent studies h...

journal_title：Current diabetes reports

authors： McGowan TA,Zhu Y,Sharma K

更新日期：2004-12-01 00:00:00

abstract：PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyper...

journal_title：Current diabetes reports

authors： Bonora BM,Avogaro A,Fadini GP

更新日期：2020-05-19 00:00:00

abstract：:Type 1 and type 2 diabetes both accelerate cardiovascular disease, yet the triggers are likely different for the two types of diabetes. Results from large-scale clinical trials suggest that intense blood glucose control can reduce cardiovascular events many years later in patients with type 1 diabetes. In type 2 diabe...

journal_title：Current diabetes reports

authors： Averill MM,Bornfeldt KE

更新日期：2009-02-01 00:00:00

abstract：:The endothelium has several diverse functions in maintaining vascular integrity in terms of structure and function. Two key vasodilators, nitric oxide (NO) and prostacyclin, maintain the vascular pathway, inhibit platelet aggregation, and are antithrombotic. More recently, they have been shown to be anti-inflammatory,...

journal_title：Current diabetes reports

authors： Dandona P

更新日期：2002-08-01 00:00:00

abstract：:Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and acti...

journal_title：Current diabetes reports

authors： Dube S,Errazuriz-Cruzat I,Basu A,Basu R

更新日期：2015-06-01 00:00:00

abstract：:National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...

journal_title：Current diabetes reports

authors： Carson JA

更新日期：2003-10-01 00:00:00

abstract：:The genomes of many species have now been completely sequenced including human and mouse. Great progress has been made in understanding the complex genetics that underlie diabetes and obesity in human populations. One of the current challenges is the functional identification and characterization of the genes within l...

journal_title：Current diabetes reports

authors： McMurray F,Moir L,Cox RD

更新日期：2012-12-01 00:00:00

abstract：:Type 2 diabetes is a progressive disease characterized by the need for additional antidiabetic agents overtime to maintain a stable level of glycemic control. The discovery of the glucagon like peptide 1, 1 of the 2 major incretins, was pivotal to the development of novel therapies, which can be used in individuals wi...

journal_title：Current diabetes reports

authors： Eckerle Mize DL,Salehi M

更新日期：2013-06-01 00:00:00

abstract：:Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...

journal_title：Current diabetes reports

authors： Borgnakke WS,Anderson PF,Shannon C,Jivanescu A

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The increasing prevalence of type 2 diabetes is driving the boundaries of clinical diabetes care outside of the traditional office setting. The purpose of this paper will be to review recent technological advances in the medical management of people with type 2 diabetes, spanning the spectrum of care ...

journal_title：Current diabetes reports

authors： Grant AK,Golden L

更新日期：2019-12-20 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by the loss of beta-cell secretory function and mass. The pathophysiology of beta-cell failure in T2DM involves a complex interaction between genetic susceptibilities and environmental risk factors. One environmental condition that is gaining...

journal_title：Current diabetes reports

authors： Rakshit K,Thomas AP,Matveyenko AV

更新日期：2014-04-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview of the current knowledge regarding the natural history of human type 1 diabetes (T1D) and the documented associations between virus infections (in particular the enteroviruses) and disease development. We review studies that examine whether T1D-specific risk alleles in genes inv...

journal_title：Current diabetes reports

authors： Blanter M,Sork H,Tuomela S,Flodström-Tullberg M

更新日期：2019-08-10 00:00:00

abstract：:This review details the epidemiology, possible mechanisms, and risk factors associated with urogenital autonomic dysfunction in diabetes. Autonomic neuropathy in diabetes is associated with various urological complications including bladder and sexual dysfunction. Several studies have reported the high prevalence of b...

journal_title：Current diabetes reports

authors： Braffett BH,Wessells H,Sarma AV

更新日期：2016-12-01 00:00:00

abstract：:Diagnostic criteria for diabetes in children have not been established with nearly the rigor as that employed in adults. Recently revised American Diabetes Association (ADA) criteria allowed utilization of hemoglobin A(1c) (HbA1c) ≥ 6.5 % for diagnosis of diabetes. A recent series of pediatric studies appear to show t...

journal_title：Current diabetes reports

authors： Kapadia CR

更新日期：2013-02-01 00:00:00

abstract：:The cardiovascular risk associated with the polycystic ovary syndrome (PCOS) has recently attracted much interest. Women with PCOS are more likely to fulfill the diagnosis of the metabolic syndrome, a cluster of related cardiometabolic factors known to predict long-term risk of cardiovascular disease and type 2 diabet...

journal_title：Current diabetes reports

authors： Cussons AJ,Stuckey BG,Watts GF

更新日期：2007-02-01 00:00:00

abstract：:The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of type 2 diabetes mellitus to the chromosome 1q21-25 region in at least eight independent studies. More than 26 candidate genes have already been evaluated, but to date none explain the evidence for linkage in this gene-dense region....

journal_title：Current diabetes reports

authors： Das SK,Elbein SC

更新日期：2007-04-01 00:00:00

abstract：:Both type 1 and type 2 diabetic patients have an increased incidence of ischemic heart disease and congestive heart failure. Cardiovascular disease accounts for up to 80% of the excess mortality in patients with type 2 diabetes. The burden of cardiovascular disease is especially pronounced in diabetic women. Factors t...

journal_title：Current diabetes reports

authors： Blendea MC,McFarlane SI,Isenovic ER,Gick G,Sowers JR

更新日期：2003-06-01 00:00:00

abstract：:Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping ...

journal_title：Current diabetes reports

authors： Mohlke KL,Boehnke M

更新日期：2005-04-01 00:00:00

abstract：:Recent studies support the concept that the retinal vasculature may provide a summary measure of lifetime exposure to the effects of hyperglycemia. Advances in retinal photographic techniques and in image analysis have allowed objective and precise in vivo measurement of retinal vascular changes. In particular, quanti...

journal_title：Current diabetes reports

authors： Nguyen TT,Wong TY

更新日期：2009-08-01 00:00:00

abstract：:In this article, we introduce the increasing prevalence of type 2 diabetes in the Japanese population and discuss the reasons for such an explosive increase. Diabetes has been brought into prominence in Japan by enhanced insulin resistance, through the change of lifestyle against the background of fragile beta-cell fu...

journal_title：Current diabetes reports

authors： Hirose T,Kawamori R

更新日期：2005-06-01 00:00:00

abstract：:Bariatric surgery has emerged as the most durably effective treatment of type 2 diabetes (DM). However, the mechanisms governing improvement in glucose homeostasis have yet to be fully elucidated. In this review we discuss the various types of surgical interventions and the multitude of factors that potentially mediat...

journal_title：Current diabetes reports

authors： Nguyen KT,Korner J

更新日期：2014-01-01 00:00:00