Abstract:
:Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping recently identified a likely susceptibility gene, hepatocyte nuclear factor 4-alpha (HNF4A). Rare loss-of-function mutations in HNF4A cause maturity-onset diabetes of the young and now common noncoding variants have been found to be associated with T2DM.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Mohlke KL,Boehnke Mdoi
10.1007/s11892-005-0043-ykeywords:
subject
Has Abstractpub_date
2005-04-01 00:00:00pages
149-56issue
2eissn
1534-4827issn
1539-0829journal_volume
5pub_type
杂志文章,评审abstract:PURPOSE OF REVIEW:A growing body of epidemiological and experimental data indicate that nutritional or environmental stressors during early development can induce long-term adaptations that increase risk of obesity, diabetes, cardiovascular disease, and other chronic conditions-a phenomenon termed "developmental progra...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1170-1
更新日期:2019-07-20 00:00:00
abstract:PURPOSE OF REVIEW:Great strides have recently been made in elucidating the role of genetic sequence variation in diabetes pathogenesis. Increasingly, studies are focusing on other factors that may contribute to the pathogenesis of diabetes, such as epigenetics, a term "traditionally" encompassing changes to the DNA tha...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1091-4
更新日期:2018-10-02 00:00:00
abstract::Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus (DM). DM is now recognized as a risk equivalent for coronary heart disease. The lipid profile in patients with type 2 DM is characterized by elevated triglycerides, low levels of high-density lipoprotein cholest...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-007-0036-0
更新日期:2007-06-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-002-0074-6
更新日期:2002-04-01 00:00:00
abstract::Diabetic patients are at increased risk for developing cardiovascular disease, and they constitute a large proportion of the global cardiovascular disease burden. Although multiple drugs exist for treating the hyperglycemia associated with diabetes, few have been shown to reduce cardiovascular risk. Great hope surroun...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-010-0099-1
更新日期:2010-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The goal of this review is to provide updates on congenital (neonatal) diabetes from 2011 to present, with an emphasis on publications from 2015 to present. RECENT FINDINGS:There has been continued worldwide progress in uncovering the genetic causes of diabetes presenting within the first year of lif...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1016-2
更新日期:2018-06-13 00:00:00
abstract:PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1243-1
更新日期:2019-12-06 00:00:00
abstract:PURPOSE OF REVIEW:Obesity is increasing at an alarming rate and now poses a global threat to humankind. In recent years, we have seen the emergence of medical devices to combat the obesity epidemic. These therapeutic strategies are discussed in this review dividing them into gastric and duodenal therapies. RECENT FIND...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1217-3
更新日期:2019-08-30 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章
doi:10.1007/s11892-008-0077-z
更新日期:2008-12-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-002-0069-3
更新日期:2002-04-01 00:00:00
abstract:PURPOSE OF REVIEW:The oral glucose tolerance test (OGTT) is used both in clinical practice and research to assess glucose tolerance. In addition, the OGTT is utilized for surrogate measures of insulin sensitivity and the insulin response to enteral glucose and has been widely applied in the evaluation of β-cell dysfunc...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1023-3
更新日期:2018-06-16 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0291-6
更新日期:2012-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Diabetic kidney disease (DKD) is the leading cause of kidney failure in the USA, representing ~ 44% of all cases of kidney failure. Advancements in both glucose management and inhibitors of the renin-angiotensin system have significantly improved prognosis for individuals with DKD, yet DKD continues t...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01314-y
更新日期:2020-06-16 00:00:00
abstract::Neonatal hypoglycemia is an important consequence for the infant of the mother with diabetes. We have reviewed 24 published papers of various protocols for control of glucose in pregnant diabetic women during labor and delivery including our own published work. A relationship of maternal glucose during labor and neona...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0450-4
更新日期:2014-01-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0673-7
更新日期:2015-11-01 00:00:00
abstract::Cardiovascular disease (CVD) remains the leading cause of death among adults with diabetes, and CVD prevention remains a major challenge. Coronary artery calcium (CAC) score measured by electron beam tomography (EBT) or multi-slice detector computed tomography correlates closely with plaque burden and coronary angiogr...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0379-7
更新日期:2013-06-01 00:00:00
abstract::Replacing dysfunctional endocrine tissues (eg, islets) with healthy, nonautologous material protected against the immune defense of the patient could soon become a reality. Recent advances have resulted in the development of alginate-based microcapsules that meet the demands of biocompatibility, long-term integrity, a...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-007-0051-1
更新日期:2007-08-01 00:00:00
abstract::National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-003-0084-z
更新日期:2003-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Ambient air pollution is strongly linked to cardiovascular and respiratory diseases. We summarize available published evidence regarding similar associations with diabetes across the life course. RECENT FINDINGS:We performed a life-course survey of the recent literature, including prenatal, gestation...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1181-y
更新日期:2019-07-19 00:00:00
abstract::Low- and middle-income countries (LMICs) face a rapid change in the nutrition transition toward increases in noncommunicable diseases. Underlying this transition are shifts in the agricultural system and the subsequent growth of the modern retail and food service sectors across all regions and countries, a change in t...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0631-4
更新日期:2015-09-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0336-x
更新日期:2013-02-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01307-x
更新日期:2020-05-19 00:00:00
abstract::Type 2 diabetes is a progressive disease characterized by the need for additional antidiabetic agents overtime to maintain a stable level of glycemic control. The discovery of the glucagon like peptide 1, 1 of the 2 major incretins, was pivotal to the development of novel therapies, which can be used in individuals wi...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0377-9
更新日期:2013-06-01 00:00:00
abstract:PURPOSE OF REVIEW:The Diabetes Prevention Program (DPP) is an evidence-based lifestyle change program for prediabetes that is associated with a 58% reduction in 3-year diabetes incidence, and it has been supported by the American Medical Association and the Centers for Disease Control and Prevention. However, 9 in 10 p...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1034-0
更新日期:2018-08-08 00:00:00
abstract::Infections of the tissue surrounding the teeth (periodontitis) are usually caused by anaerobic gram-negative microorganisms. This infection causes destruction of the supporting alveolar bone and can lead to tooth loss. Removal of these microorganisms can slow or arrest the progression of periodontitis. Diabetes patien...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-004-0011-y
更新日期:2004-02-01 00:00:00
abstract:PURPOSE OF REVIEW:This study aims to examine the operationalisation of 'psychological insulin resistance' (PIR) among people with type 2 diabetes and to identify and critique relevant measures. RECENT FINDINGS:PIR has been operationalised as (1) the assessment of attitudes or beliefs about insulin therapy and (2) hypo...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0873-4
更新日期:2017-07-01 00:00:00
abstract:PURPOSE OF REVIEW:To highlight pathways important for the development of autoimmune diabetes by investigating shared mechanisms of disease in polygenic and monogenic diabetes. RECENT FINDINGS:Genome-wide association studies have identified 57 genetic risk loci for type 1 diabetes. Progress has been made in unravelling...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1141-6
更新日期:2019-03-19 00:00:00
abstract::The occurrence and progression of nephropathy associated with early onset type 2 diabetes (T2D) is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emerge...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0456-y
更新日期:2014-02-01 00:00:00
abstract::The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0347-7
更新日期:2013-02-01 00:00:00
abstract:PURPOSE OF REVIEW:The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown whether this treatment is also suitable for patients with obesity due to a co...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01327-7
更新日期:2020-07-30 00:00:00