Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

abstract：:Although type 1 diabetes remains the most common type of diabetes in the pediatric population, there has been a dramatic rise in type 2 diabetes in youth. Clinical distinctions between these two major types have become blurred. As genetic and biochemical measures become more affordable and available, practical applica...

journal_title：Current diabetes reports

authors： Pihoker C

更新日期：2006-04-01 00:00:00

abstract：:Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...

journal_title：Current diabetes reports

authors： Durnwald CP,Landon MB

更新日期：2011-02-01 00:00:00

abstract：:Hyperglycemia is common following organ transplantation, regardless of the pre-transplant diabetes status. Transient post-transplant hyperglycemia and/or new-onset diabetes after transplantation (NODAT) are common and are associated with increased morbidity and mortality. NODAT and type 2 diabetes share similar charac...

journal_title：Current diabetes reports

authors： Galindo RJ,Wallia A

更新日期：2016-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Great strides have recently been made in elucidating the role of genetic sequence variation in diabetes pathogenesis. Increasingly, studies are focusing on other factors that may contribute to the pathogenesis of diabetes, such as epigenetics, a term "traditionally" encompassing changes to the DNA tha...

journal_title：Current diabetes reports

authors： Zhang H,Pollin TI

更新日期：2018-10-02 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the study is to examine and summarize studies reporting on the epidemiology, the risk of developing diabetes, and the cardiovascular effects on individuals with diabetes of different levels of alcohol consumption. RECENT FINDINGS:Men consume more alcohol than women in populations with ...

journal_title：Current diabetes reports

authors： Polsky S,Akturk HK

更新日期：2017-11-04 00:00:00

abstract：:Overnutrition is a major cause of diabetes. The contrary situation of undernutrition has also been suggested to increase the risk of the disease. Especially undernutrition during prenatal life has been hypothesized to program the structure and physiology of the fetus in such a way that it is more prone to develop diab...

journal_title：Current diabetes reports

authors： de Rooij SR,Roseboom TJ,Painter RC

更新日期：2014-10-01 00:00:00

abstract：:Diabetes is a chronic disease that affects over 25 million adults, many of whom are smokers. The negative health impact of diabetes and comorbid smoking is significant and requires comprehensive interdisciplinary management. The National Diabetes Education Program has identified specific providers, known as PPOD, who ...

journal_title：Current diabetes reports

authors： Register SJ,Harrington KF,Agne AA,Cherrington AL

更新日期：2016-09-01 00:00:00

abstract：:Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are fur...

journal_title：Current diabetes reports

authors： Zilliox LA,Chadrasekaran K,Kwan JY,Russell JW

更新日期：2016-09-01 00:00:00

abstract：:Cardiovascular disease (CVD) remains the leading cause of death among adults with diabetes, and CVD prevention remains a major challenge. Coronary artery calcium (CAC) score measured by electron beam tomography (EBT) or multi-slice detector computed tomography correlates closely with plaque burden and coronary angiogr...

journal_title：Current diabetes reports

authors： Snell-Bergeon JK,Budoff MJ,Hokanson JE

更新日期：2013-06-01 00:00:00

abstract：:Diabetes mellitus and obesity have become increasingly prevalent problems worldwide. Unfortunately, with traditionally prescribed glucose-lowering medications most individuals with diagnosed diabetes do not achieve and maintain adequate glycemic control over time; it may be even more challenging to lower blood glucose...

journal_title：Current diabetes reports

authors： Green JB,Feinglos MN

更新日期：2007-10-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a vision-threatening complication of diabetes. Timely diagnosis and intervention are essential for treatment that reduces the risk of vision loss. A good color retinal (fundus) photograph can be used as a surrogate for face-to-face evaluation of DR. The use of computers to assist or fully ...

journal_title：Current diabetes reports

authors： Li B,Li HK

更新日期：2013-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 2 diabetes is common, burdensome, and preventable. Landmark trials such as the Diabetes Prevention Program (DPP) demonstrated that resource-intensive lifestyle support interventions resulting in modest weight loss via healthy diet changes and physical activity can lower the rate of diabetes devel...

journal_title：Current diabetes reports

authors： Ackermann RT,O'Brien MJ

更新日期：2020-02-20 00:00:00

abstract：:A large body of evidence indicates that the risk for developing chronic diabetic complications is under the control of genetic factors. Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropath...

journal_title：Current diabetes reports

authors： Doria A

更新日期：2010-12-01 00:00:00

abstract：:The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related ...

journal_title：Current diabetes reports

authors： Giannini C,Caprio S

更新日期：2013-02-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease found in 3% to 9% of children in the United States. NAFLD represents a spectrum of liver disease and is frequently associated with features of the metabolic syndrome. Nutrition's role in NAFLD is complex. It does not appear that overweight...

journal_title：Current diabetes reports

authors： Vos MB,McClain CJ

更新日期：2008-10-01 00:00:00

abstract：:The incidence of both type 1 and type 2 diabetes is increasing globally, most likely explained by environmental changes, such as changing exposures to foods, viruses, and toxins, and by increasing obesity. While cardiovascular disease (CVD) mortality has been declining recently, this global epidemic of diabetes threat...

journal_title：Current diabetes reports

authors： Duca L,Sippl R,Snell-Bergeon JK

更新日期：2013-06-01 00:00:00

abstract：:Although numerous chemokine/chemokine receptor pathways have been described to be implicated in the pathogenesis of type 1 diabetes (T1D), the CXCR1/2 axis has recently been proved to be crucial for leucocyte recruitment involved in insulitis and β cell damage. Multiple strategies blocking the CXCR1/2 pathway are avai...

journal_title：Current diabetes reports

authors： Citro A,Cantarelli E,Piemonti L

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Diabetic retinopathy remains the leading cause of blindness among working-age US adults even though timely screening and treatment prevent 90% of blindness. We summarize current knowledge and perspectives to better understand why diabetic eye screening rates remain low and future directions towards pr...

journal_title：Current diabetes reports

authors： Liu Y,Swearingen R

更新日期：2017-08-31 00:00:00

abstract：:Recent estimates suggest that 1 in 12 of the global population suffers from diabetes mellitus. Approximately 40 % of those affected will go on to develop diabetes-related chronic kidney disease or diabetic nephropathy (DN). DN is a major cause of disability and premature death. Existing tests for prognostic purposes a...

journal_title：Current diabetes reports

authors： Simpson K,Wonnacott A,Fraser DJ,Bowen T

更新日期：2016-03-01 00:00:00

abstract：PURPOSE OF REVIEW:Gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. In the USA, four million women are screened annually for GDM in pregnancy in part to improve pregnancy outcomes but also because diagnosis predicts a high risk of future type 2 diabetes mellitus (T2DM). T...

journal_title：Current diabetes reports

authors： Hamel MS,Werner EF

更新日期：2017-02-01 00:00:00

abstract：:Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...

journal_title：Current diabetes reports

authors： Borgnakke WS,Anderson PF,Shannon C,Jivanescu A

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS:Problems in cognitive...

journal_title：Current diabetes reports

authors： Wiebe DJ,Berg CA,Mello D,Kelly CS

更新日期：2018-03-21 00:00:00

abstract：PURPOSE OF REVIEW:Diabetic nephropathy, a major microvascular complication of diabetes and the most common cause of end-stage renal disease, is characterized by prominent accumulation of extracellular matrix. The membrane microdomains caveolae, and their integral protein caveolin-1, play critical roles in the regulatio...

journal_title：Current diabetes reports

authors： Van Krieken R,Krepinsky JC

更新日期：2017-03-01 00:00:00

abstract：:The occurrence and progression of nephropathy associated with early onset type 2 diabetes (T2D) is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emerge...

journal_title：Current diabetes reports

authors： Solis-Herrera C,Triplitt CL,Lynch JL

更新日期：2014-02-01 00:00:00

abstract：:According to a 2010 national survey, 11 % of adults in China have diabetes, affecting 109.6 million individuals. The high prevalence of diabetes has been attributed to the aging of the population, the rapid adoption of energy-dense foods, and a reduction in physical activity. Collectively, these secular changes have c...

journal_title：Current diabetes reports

authors： Yin J,Kong AP,Chan JC

更新日期：2016-12-01 00:00:00

abstract：:There is a well-documented gap between research and practice in diabetes and many other chronic illnesses. This gap is due, in part, to limitations of the research database. Different types of clinical trials have recently been called for that address issues central to clinicians, administrative decision makers, and p...

journal_title：Current diabetes reports

authors： Glasgow RE

更新日期：2004-04-01 00:00:00

abstract：:The insulin resistance syndrome (IRS) is a common disorder, which has important clinical implications. It is a cluster of cardiovascular risk factors that include obesity, hypertension, dyslipidemia, glucose intolerance, and type 2 diabetes mellitus. Lifestyle modifications and insulin sensitizers are among the severa...

journal_title：Current diabetes reports

authors： Desouza C,Gilling L,Fonseca V

更新日期：2001-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...

journal_title：Current diabetes reports

authors： Allweiss P

更新日期：2019-11-20 00:00:00

abstract：:Hypoglycemia is a frequent occurrence in children and adolescents with type 1 diabetes. A variety of efforts have been made to standardize the definition of hypoglycemia and to define one of its most significant psychosocial consequences-fear of hypoglycemia (FOH). In addition to documenting the experience of FOH in c...

journal_title：Current diabetes reports

authors： Driscoll KA,Raymond J,Naranjo D,Patton SR

更新日期：2016-08-01 00:00:00

abstract：:Suspicion that fructose-containing caloric sweeteners (FCCS) may play a causal role in the development of metabolic diseases has elicited intense basic and clinical research over the past 10 years. Prospective cohort studies converge to indicate that FCCS, and more specifically sugar-sweetened beverages (SSBs), consum...

journal_title：Current diabetes reports

authors： Tappy L,Lê KA

更新日期：2015-08-01 00:00:00