Abstract：
PURPOSE OF REVIEW:Diabetic kidney disease (DKD) is the leading cause of kidney failure in the USA, representing ~ 44% of all cases of kidney failure. Advancements in both glucose management and inhibitors of the renin-angiotensin system have significantly improved prognosis for individuals with DKD, yet DKD continues to affect 30-40% of people with type 2 diabetes and is still a major predictor of mortality in this population. Thus, new interventions are required to address this significant health burden. RECENT FINDINGS:One potential target for intervention is cellular senescence. Senescence permanently arrests cell division in response to genotoxic, oncogenic, or metabolic stresses-coupled to the secretion of inflammatory cytokines, chemokines, growth factors, proteases, and other molecules that can have potent local and systemic effects. This senescence-associated secretory phenotype (SASP) explains how a relatively small number of senescent cells can promote pathology, and a growing number of degenerative conditions have been found to be caused or aggravated by senescent cells. Many SASP factors are also associated with loss of kidney function. Targeted elimination of senescent cells prevents the development of several degenerative pathologies. Since senescent cells appear in the proximal tubules and podocytes of patients with DKD, they are an appealing target for intervention in these disorders. Here, we review the current literature linking senescence to DKD and speculate on the likely routes to intervention in a clinical setting.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Wiley CDdoi
10.1007/s11892-020-01314-ysubject
Has Abstractpub_date
2020-06-16 00:00:00pages
33issue
8eissn
1534-4827issn
1539-0829pii
10.1007/s11892-020-01314-yjournal_volume
20pub_type
杂志文章,评审abstract：PURPOSE OF REVIEW:This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS:Problems in cognitive...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-0995-3
更新日期：2018-03-21 00:00:00
abstract：PURPOSE OF REVIEW:This review aims to discuss the burden of type 2 diabetes in youth and summarize the studies that have utilized noninvasive techniques to assess early vascular disease in youth with type 2 diabetes. RECENT FINDINGS:Noninvasive imaging modalities provide researchers with tools to investigate the vascu...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-017-0869-0
更新日期：2017-06-01 00:00:00
abstract：:Diabetic nephropathy is a clinical syndrome of albuminuria, declining glomerular filtration rate, and increased risk of cardiovascular disease. Multiple mechanisms have been implicated in its pathogenesis. Although current therapies appear to be effective, treatment of diabetic nephropathy remains suboptimal. This rev...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-005-0057-5
更新日期：2005-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell bi...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1166-x
更新日期：2019-07-04 00:00:00
abstract：:Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-004-0037-1
更新日期：2004-10-01 00:00:00
abstract：:Diabetic nephropathy is continuing to rise in incidence, despite awareness of tight glycemic control and blood pressure. The identification that matrix accumulation is driven by transforming growth factor-beta (TGF-beta) has led to a concerted effort to apply antifibrotic strategies for this disorder. Recent studies h...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-004-0055-z
更新日期：2004-12-01 00:00:00
abstract：:Little published research exists on psychosocial issues in adolescents with type 2 diabetes mellitus (T2DM), because until two decades ago, diabetes diagnosed in children and adolescents was almost exclusively type 1 diabetes mellitus or insulin-dependent diabetes. In the past two decades, rates of T2DM have increased...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-009-0025-6
更新日期：2009-04-01 00:00:00
abstract：:Type 1 diabetes (T1D) is a complex chronic disease that has many facets for successful management. The burden of this management falls largely on the individual and their family members. Self-management has a major influence on T1D health outcomes, and with successful management, children and adolescents with T1D can ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0544-7
更新日期：2014-01-01 00:00:00
abstract：:Proliferative diabetic retinopathy (PDR), characterized by pathologic retinal angiogenesis, is a major cause of blindness in the USA and globally. Treatments targeting vascular endothelial growth factor (VEGF) have emerged as a beneficial part of the therapeutic armamentarium for this condition, highlighting the utili...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-012-0289-0
更新日期：2012-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Obesity in the older adult is a burgeoning health epidemic that leads to increased morbidity, disability, and institutionalization. This review presents a brief overview of geriatric-specific consequences of obesity by highlighting the risks and benefits of intentional weight loss. RECENT FINDINGS:In...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1249-8
更新日期：2019-11-04 00:00:00
abstract：:Worldwide increases in diabetes prevalence in the face of limited medical resources have prompted international interest in innovative healthcare delivery models. Project ECHO (Extension for Community Healthcare Outcomes) is a "telementoring" program which has been shown to increase capacity for complex disease manage...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0784-9
更新日期：2016-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Obesity and its associated metabolic diseases have reached epidemic proportions worldwide, reducing life expectancy and quality of life. Several drugs have been tested to treat these diseases but many of them have damaging side effects. Consequently, there is an urgent need to develop more effective t...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-017-0866-3
更新日期：2017-06-01 00:00:00
abstract：:Exercise has long been recognized as a cornerstone in diabetes care. Even so, modern science is just beginning to understand the physiologic impact cardiovascular fitness has on long-term diabetes management, and the prevention or delay, of type 2 diabetes. Recent advances in research are defining the metabolic pathwa...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-002-0109-z
更新日期：2002-10-01 00:00:00
abstract：:Both type 1 and type 2 diabetic patients have an increased incidence of ischemic heart disease and congestive heart failure. Cardiovascular disease accounts for up to 80% of the excess mortality in patients with type 2 diabetes. The burden of cardiovascular disease is especially pronounced in diabetic women. Factors t...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-003-0068-z
更新日期：2003-06-01 00:00:00
abstract：:Microalbuminuria clusters with the metabolic syndrome, and both conditions predict cardiovascular disease mortality. The reported relationships of microalbuminuria with the individual components of the metabolic syndrome (i.e., hyperglycemia, insulin resistance, hypertension, dyslipidemia, abdominal obesity) are varia...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-003-0058-1
更新日期：2003-02-01 00:00:00
abstract：:The genomes of many species have now been completely sequenced including human and mouse. Great progress has been made in understanding the complex genetics that underlie diabetes and obesity in human populations. One of the current challenges is the functional identification and characterization of the genes within l...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-012-0323-2
更新日期：2012-12-01 00:00:00
abstract：:Among the spectrum of risk for diabetic foot disease conferred by chronic kidney disease (CKD), end-stage renal disease (ESRD) has emerged as a novel independent risk factor. Apart from the classical triad of neuropathy, infection, and peripheral arterial disease that operate in these individuals, the risk is further ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-010-0128-0
更新日期：2010-08-01 00:00:00
abstract：:Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-005-0043-y
更新日期：2005-04-01 00:00:00
abstract：PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1243-1
更新日期：2019-12-06 00:00:00
abstract：:The occurrence and progression of nephropathy associated with early onset type 2 diabetes (T2D) is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emerge...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-013-0456-y
更新日期：2014-02-01 00:00:00
abstract：:Erectile dysfunction (ED) is more commonly seen in men with various components of the metabolic syndrome (a constellation of various cardiovascular and diabetes risk factors). ED can be considered as a risk marker of the metabolic syndrome and its associated conditions. The patient with ED should be thoroughly evaluat...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-005-0070-8
更新日期：2005-02-01 00:00:00
abstract：:Replacing dysfunctional endocrine tissues (eg, islets) with healthy, nonautologous material protected against the immune defense of the patient could soon become a reality. Recent advances have resulted in the development of alginate-based microcapsules that meet the demands of biocompatibility, long-term integrity, a...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-007-0051-1
更新日期：2007-08-01 00:00:00
abstract：:Cardiovascular disease is a leading cause of death and disability in patients with diabetes or metabolic syndrome (MS). The available data suggest that many patients with diabetes or MS already have vascular abnormalities by the time they are diagnosed with their metabolic disorder. Endothelial dysfunction (ED), which...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-003-0019-8
更新日期：2003-08-01 00:00:00
abstract：:Type 2 diabetes is a progressive disease characterized by the need for additional antidiabetic agents overtime to maintain a stable level of glycemic control. The discovery of the glucagon like peptide 1, 1 of the 2 major incretins, was pivotal to the development of novel therapies, which can be used in individuals wi...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-013-0377-9
更新日期：2013-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Obesity is closely linked with the pathogenesis of type 2 diabetes (T2DM) and cardiovascular disease (CVD), and whilst smoking cessation is associated with weight gain, there are concerns that this weight gain may offset the benefit of CVD risk reduction especially in those with considerable post-cess...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-020-01352-6
更新日期：2020-12-08 00:00:00
abstract：PURPOSE OF REVIEW:A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Cont...
journal_title：Current diabetes reports
pub_type： 杂志文章
doi：10.1007/s11892-018-0981-9
更新日期：2018-02-19 00:00:00
abstract：:Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0753-3
更新日期：2016-07-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an updated summary of discoveries made to date resulting from genome-wide association study (GWAS) and sequencing studies, and to discuss the latest loci added to the growing repertoire of genetic signals predisposing to type 1 diabetes (T1D). RECENT FINDINGS:Genetic studies have identifie...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1235-1
更新日期：2019-11-04 00:00:00
abstract：:Diabetes mellitus is a chronic disease with a higher risk of associated infections. HIV infection severely affects diabetic patients and acts as a significant health concern. Highly active antiretroviral therapy (HAART) has changed HIV from an acute infection to a chronic infection with associated significant metaboli...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-013-0369-9
更新日期：2013-06-01 00:00:00
abstract：:Bile acids are generated in the liver and are traditionally recognized for their regulatory role in multiple metabolic processes including bile acid homeostasis, nutrient absorption, and cholesterol homeostasis. Recently, bile acids emerged as signaling molecules that, as ligands for the bile acid receptors farnesoid ...
journal_title：Current diabetes reports
pub_type： 杂志文章
doi：10.1007/s11892-009-0087-5
更新日期：2010-02-01 00:00:00
