Abstract：
:Proliferative diabetic retinopathy (PDR), characterized by pathologic retinal angiogenesis, is a major cause of blindness in the USA and globally. Treatments targeting vascular endothelial growth factor (VEGF) have emerged as a beneficial part of the therapeutic armamentarium for this condition, highlighting the utility of identifying and targeting specific pathogenic molecules. There continues to be active research into the molecular players regulating retinal angiogenesis, including pro-angiogenic factors, anti-angiogenic factors, and integrins and matrix proteinases. New insights have been especially prominent regarding molecules which regulate specialized endothelial cells called tip cells, which play a lead role in endothelial sprouting. Together, these research efforts are uncovering new, important molecular regulators of retinal angiogenesis, which provide fertile areas for therapeutic exploration. This review discusses potential molecular targets, with an emphasis towards newer targets.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Wang S,Park JK,Duh EJdoi
10.1007/s11892-012-0289-0subject
Has Abstractpub_date
2012-08-01 00:00:00pages
355-63issue
4eissn
1534-4827issn
1539-0829journal_volume
12pub_type
杂志文章,评审abstract：:Marijuana is used by millions of people, with use likely to increase in the USA because of the trend towards increased decriminalization and legalization. Obesity and diabetes mellitus (DM) rates have increased dramatically in the USA over the past 30 years, with a recent estimate of 29 million individuals with DM. Be...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0795-6
更新日期：2016-11-01 00:00:00
abstract：PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell bi...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1166-x
更新日期：2019-07-04 00:00:00
abstract：PURPOSE OF REVIEW:Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). RECENT FINDINGS:T...
journal_title：Current diabetes reports
pub_type： 杂志文章
doi：10.1007/s11892-017-0864-5
更新日期：2017-06-01 00:00:00
abstract：:Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-012-0294-3
更新日期：2012-10-01 00:00:00
abstract：:Cardiovascular disease is a leading cause of death and disability in patients with diabetes or metabolic syndrome (MS). The available data suggest that many patients with diabetes or MS already have vascular abnormalities by the time they are diagnosed with their metabolic disorder. Endothelial dysfunction (ED), which...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-003-0019-8
更新日期：2003-08-01 00:00:00
abstract：:In this review article, we first present a brief overview of the vascular and neural components of diabetic retinopathy. Next, the multifocal electroretinogram (mfERG) technique, which can map neuroretinal function noninvasively, is described. Findings in diabetic retinal disease using the mfERG are reviewed. We then ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0526-9
更新日期：2014-01-01 00:00:00
abstract：:Although type 1 diabetes remains the most common type of diabetes in the pediatric population, there has been a dramatic rise in type 2 diabetes in youth. Clinical distinctions between these two major types have become blurred. As genetic and biochemical measures become more affordable and available, practical applica...
journal_title：Current diabetes reports
pub_type： 杂志文章
doi：10.1007/s11892-006-0020-0
更新日期：2006-04-01 00:00:00
abstract：PURPOSE OF REVIEW:A growing body of epidemiological and experimental data indicate that nutritional or environmental stressors during early development can induce long-term adaptations that increase risk of obesity, diabetes, cardiovascular disease, and other chronic conditions-a phenomenon termed "developmental progra...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1170-1
更新日期：2019-07-20 00:00:00
abstract：:Of the many innovations in health care delivery proposed in the context of health reform for those with chronic diseases such as diabetes, the group visit model is relatively easy to implement and is effective for improving health outcomes and patient and provider satisfaction, with a neutral to positive effect on hea...
journal_title：Current diabetes reports
pub_type： 杂志文章
doi：10.1007/s11892-012-0349-5
更新日期：2013-04-01 00:00:00
abstract：:The incidence of both type 1 and type 2 diabetes is increasing globally, most likely explained by environmental changes, such as changing exposures to foods, viruses, and toxins, and by increasing obesity. While cardiovascular disease (CVD) mortality has been declining recently, this global epidemic of diabetes threat...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-013-0380-1
更新日期：2013-06-01 00:00:00
abstract：:Among the factors predisposing to type 2 diabetes in children, adolescents, and young adults, the health and behavior of both the mother and father are critical. Prevention and treatment of parental nutritional disorders (including obesity and malnutrition), promotion of breastfeeding, and avoidance of overfeeding of ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-011-0246-3
更新日期：2012-02-01 00:00:00
abstract：:Type 1 diabetes (T1D) is a complex chronic disease that has many facets for successful management. The burden of this management falls largely on the individual and their family members. Self-management has a major influence on T1D health outcomes, and with successful management, children and adolescents with T1D can ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0544-7
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:To highlight pathways important for the development of autoimmune diabetes by investigating shared mechanisms of disease in polygenic and monogenic diabetes. RECENT FINDINGS:Genome-wide association studies have identified 57 genetic risk loci for type 1 diabetes. Progress has been made in unravelling...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1141-6
更新日期：2019-03-19 00:00:00
abstract：PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-020-01347-3
更新日期：2020-10-11 00:00:00
abstract：PURPOSE OF REVIEW:Currently, the diagnosis of gestational diabetes mellitus (GDM) lacks uniformity. Several controversies are still under debate, especially on the method of screening and diagnosis. This review focuses on recent literature and provides current evidence for the screening and diagnosis of GDM. RECENT FI...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1271-x
更新日期：2019-12-04 00:00:00
abstract：PURPOSE OF REVIEW:In this brief review, we highlight studies that have contributed to our current understanding of glucose homeostasis by the central nervous system (CNS) leptin-melanocortin system, particularly proopiomelanocortin neurons and melanocortin-4 receptors (MC4R). RECENT FINDINGS:Leptin deficiency is assoc...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-020-01311-1
更新日期：2020-05-26 00:00:00
abstract：:Recent evidence points to the crucial role of the central nervous system in controlling glucose homeostasis. Hypothalamic centers involved in the regulation of energy balance and endogenous glucose production constantly sense fuel availability by receiving and integrating inputs from circulating nutrients and hormones...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-006-0033-8
更新日期：2006-06-01 00:00:00
abstract：:In nondiabetic individuals, a poor response to an endothelium-dependent vasodilator in coronary vessels has been shown to increase the likelihood of a future cardiovascular event. Such prospective data are not as yet available in patients with type 1 or type 2 diabetes. However, consistent with the greatly increased c...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-002-0054-x
更新日期：2002-02-01 00:00:00
abstract：PURPOSE OF REVIEW:Our review provides a brief summary of the most recent advances towards the identification of the genetic basis of specific aspects of obesity and the quantification of their consequences on health. We also highlight the most promising avenues to be explored in the future. RECENT FINDINGS:While obesi...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-020-1285-4
更新日期：2020-01-22 00:00:00
abstract：:Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-015-0673-7
更新日期：2015-11-01 00:00:00
abstract：:Worldwide increases in diabetes prevalence in the face of limited medical resources have prompted international interest in innovative healthcare delivery models. Project ECHO (Extension for Community Healthcare Outcomes) is a "telementoring" program which has been shown to increase capacity for complex disease manage...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0784-9
更新日期：2016-10-01 00:00:00
abstract：:The prevalence of diabetes is two- to threefold higher in American Indians in Montana compared with the non-Indian population. High rates of diabetes have also been described in Canadian aboriginal populations closely related to the tribes in Montana. Diabetes in pregnancy has increased among Indian mothers and high-b...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-004-0028-2
更新日期：2004-06-01 00:00:00
abstract：PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1218-2
更新日期：2019-09-10 00:00:00
abstract：:Erectile dysfunction (ED) is more commonly seen in men with various components of the metabolic syndrome (a constellation of various cardiovascular and diabetes risk factors). ED can be considered as a risk marker of the metabolic syndrome and its associated conditions. The patient with ED should be thoroughly evaluat...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-005-0070-8
更新日期：2005-02-01 00:00:00
abstract：:Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-004-0037-1
更新日期：2004-10-01 00:00:00
abstract：:Fasting glucose and hemoglobin A1c (HbA1c) are the standard measures for diagnosis and monitoring of diabetes. There has been recent interest in nontraditional markers of hyperglycemia, including fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG), as alternatives or adjuncts to standard measures. There i...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0548-3
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:Obesity and diabetes are worldwide epidemics. There is also a growing body of evidence relating the gut microbiome composition to insulin resistance. The purpose of this review is to delineate the studies linking gut microbiota to obesity, metabolic syndrome, and diabetes. RECENT FINDINGS:Animal stud...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1104-3
更新日期：2018-10-18 00:00:00
abstract：PURPOSE OF REVIEW:The goal of this review is to provide updates on congenital (neonatal) diabetes from 2011 to present, with an emphasis on publications from 2015 to present. RECENT FINDINGS:There has been continued worldwide progress in uncovering the genetic causes of diabetes presenting within the first year of lif...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1016-2
更新日期：2018-06-13 00:00:00
abstract：:The endothelium has several diverse functions in maintaining vascular integrity in terms of structure and function. Two key vasodilators, nitric oxide (NO) and prostacyclin, maintain the vascular pathway, inhibit platelet aggregation, and are antithrombotic. More recently, they have been shown to be anti-inflammatory,...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-002-0019-0
更新日期：2002-08-01 00:00:00
abstract：:Diabetic nephropathy has become the main cause of renal failure, but unfortunately the intimate mechanisms leading to the development and progression of renal injury are not yet fully known. Activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes. Moreover, different inflammator...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-006-0080-1
更新日期：2006-12-01 00:00:00
