Bioprinting an Artificial Pancreas for Type 1 Diabetes.

Abstract:

PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell biology has provided the means to overcome these challenges. RECENT FINDINGS:3D bioprinting allows for the precise fabrication of complex 3D architectures containing spatially distributed cells, biomaterials (bioink), and bioactive factors. Different strategies to capitalize on this ability have been investigated for the 3D bioprinting of pancreatic islets. In particular, with co-axial bioprinting technology, the co-printability of islets with supporting cells such as endothelial progenitor cells and regulatory T cells, which have been shown to accelerate revascularization of islets and improve the outcome of various transplantations, respectively, has been achieved. 3D bioprinting of islets for generation of an artificial pancreas is a newly emerging field of study with a vast potential to improve islet transplantation.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Kim J,Kang K,Drogemuller CJ,Wallace GG,Coates PT

doi

10.1007/s11892-019-1166-x

subject

Has Abstract

pub_date

2019-07-04 00:00:00

pages

53

issue

8

eissn

1534-4827

issn

1539-0829

pii

10.1007/s11892-019-1166-x

journal_volume

19

pub_type

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