Beyond HbA1c and glucose: the role of nontraditional glycemic markers in diabetes diagnosis, prognosis, and management.

abstract：:Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectiv...

journal_title：Current diabetes reports

authors： Khalaf KI,Taegtmeyer H

更新日期：2013-04-01 00:00:00

abstract：:Diabetic nephropathy is continuing to rise in incidence, despite awareness of tight glycemic control and blood pressure. The identification that matrix accumulation is driven by transforming growth factor-beta (TGF-beta) has led to a concerted effort to apply antifibrotic strategies for this disorder. Recent studies h...

journal_title：Current diabetes reports

authors： McGowan TA,Zhu Y,Sharma K

更新日期：2004-12-01 00:00:00

abstract：:Charcot neuro-osteoarthropathy (CN) is among the most devastating complications of neuropathy and now most commonly occurs in the feet of diabetic patients. Because it is relatively rare and because most patients and practitioners do not expect major bone pathology in the absence of significant pain, CN is often misdi...

journal_title：Current diabetes reports

authors： Ulbrecht JS,Wukich DK

更新日期：2008-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide updates on congenital (neonatal) diabetes from 2011 to present, with an emphasis on publications from 2015 to present. RECENT FINDINGS:There has been continued worldwide progress in uncovering the genetic causes of diabetes presenting within the first year of lif...

journal_title：Current diabetes reports

authors： Letourneau LR,Greeley SAW

更新日期：2018-06-13 00:00:00

abstract：:The term prediabetes refers to subjects with impaired fasting glucose and/or impaired glucose tolerance who are at increased risk for type 2 diabetes mellitus. Although both types of patients are at increased risk for developing type 2 diabetes mellitus and cardiovascular disease, they manifest distinct metabolic abno...

journal_title：Current diabetes reports

authors： Abdul-Ghani MA,DeFronzo RA

更新日期：2009-06-01 00:00:00

abstract：:Maintaining normal blood glucose levels is a constant challenge for women with diabetes. Anecdotal reports reveal that many women question if menstrual cycle phases may affect their blood glucose levels. However, results from studies investigating the effect of the menstrual cycle on insulin sensitivity in diabetic wo...

journal_title：Current diabetes reports

authors： Trout KK,Teff KL

更新日期：2004-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Neuropathic pain may arise from multiple mechanisms and locations. Efficacy of current treatments for painful diabetic neuropathy is limited to an unpredictable subset of patients, possibly reflecting diversity of pain generator mechanisms, and there is a lack of targeted treatments for individual pat...

journal_title：Current diabetes reports

authors： Lee-Kubli C,Marshall AG,Malik RA,Calcutt NA

更新日期：2018-01-23 00:00:00

abstract：PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...

journal_title：Current diabetes reports

authors： Honasoge A,Nudleman E,Smith M,Rajagopal R

更新日期：2019-09-10 00:00:00

abstract：PURPOSE OF REVIEW:The Diabetes Prevention Program (DPP) is an evidence-based lifestyle change program for prediabetes that is associated with a 58% reduction in 3-year diabetes incidence, and it has been supported by the American Medical Association and the Centers for Disease Control and Prevention. However, 9 in 10 p...

journal_title：Current diabetes reports

authors： Jasik CB,Joy E,Brunisholz KD,Kirley K

更新日期：2018-08-08 00:00:00

abstract：PURPOSE OF REVIEW:The micro/macrovascular complications of diabetes cause considerable morbidity and premature mortality. The SGLT2 inhibitors are the first diabetes medications with significant benefits on microvascular disease (nephropathy) and macrovascular cardiovascular disease. In this review, we evaluate one of ...

journal_title：Current diabetes reports

authors： Ekanayake P,Hupfeld C,Mudaliar S

更新日期：2020-11-23 00:00:00

abstract：:Diabetic polyneuropathy (DPN) is the most common complication that emerges early in patients who have diabetes. Curative treatment for overt or symptomatic DPN has not been established, requiring much effort to explore new modalities. Thus, the use of various kinds of stem cells as a potential therapeutic option for D...

journal_title：Current diabetes reports

authors： Mizukami H,Yagihashi S

更新日期：2016-09-01 00:00:00

abstract：:Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...

journal_title：Current diabetes reports

authors： Rickels MR

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...

journal_title：Current diabetes reports

authors： Blair RA,Rosenberg EA,Palermo NE

更新日期：2019-12-06 00:00:00

abstract：:Pharmacologic doses of glucocorticoids and chronic renal failure are challenging comorbidities and complications for safe and effective dosing of insulin for the management of hospitalized patients with diabetes. Glucocorticoids are used widely in hospitalized patients and will commonly provoke new-onset hyperglycemia...

journal_title：Current diabetes reports

authors： Baldwin D,Apel J

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyper...

journal_title：Current diabetes reports

authors： Bonora BM,Avogaro A,Fadini GP

更新日期：2020-05-19 00:00:00

abstract：:The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gene are associated no...

journal_title：Current diabetes reports

authors： Zhao X,Yang Y,Sun BF,Zhao YL,Yang YG

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of the study is to examine and summarize studies reporting on the epidemiology, the risk of developing diabetes, and the cardiovascular effects on individuals with diabetes of different levels of alcohol consumption. RECENT FINDINGS:Men consume more alcohol than women in populations with ...

journal_title：Current diabetes reports

authors： Polsky S,Akturk HK

更新日期：2017-11-04 00:00:00

abstract：:Goal setting is a widely used behavior change tool in diabetes education and training. Prior research found specific relatively difficult but attainable goals set within a specific timeframe improved performance in sports and at the workplace. However, the impact of goal setting in diabetes self-care has not received ...

journal_title：Current diabetes reports

authors： Miller CK,Bauman J

更新日期：2014-08-01 00:00:00

abstract：:The cardiovascular risk associated with the polycystic ovary syndrome (PCOS) has recently attracted much interest. Women with PCOS are more likely to fulfill the diagnosis of the metabolic syndrome, a cluster of related cardiometabolic factors known to predict long-term risk of cardiovascular disease and type 2 diabet...

journal_title：Current diabetes reports

authors： Cussons AJ,Stuckey BG,Watts GF

更新日期：2007-02-01 00:00:00

abstract：:Suspicion that fructose-containing caloric sweeteners (FCCS) may play a causal role in the development of metabolic diseases has elicited intense basic and clinical research over the past 10 years. Prospective cohort studies converge to indicate that FCCS, and more specifically sugar-sweetened beverages (SSBs), consum...

journal_title：Current diabetes reports

authors： Tappy L,Lê KA

更新日期：2015-08-01 00:00:00

abstract：:Proliferative diabetic retinopathy (PDR), characterized by pathologic retinal angiogenesis, is a major cause of blindness in the USA and globally. Treatments targeting vascular endothelial growth factor (VEGF) have emerged as a beneficial part of the therapeutic armamentarium for this condition, highlighting the utili...

journal_title：Current diabetes reports

authors： Wang S,Park JK,Duh EJ

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 2 diabetes is common, burdensome, and preventable. Landmark trials such as the Diabetes Prevention Program (DPP) demonstrated that resource-intensive lifestyle support interventions resulting in modest weight loss via healthy diet changes and physical activity can lower the rate of diabetes devel...

journal_title：Current diabetes reports

authors： Ackermann RT,O'Brien MJ

更新日期：2020-02-20 00:00:00

abstract：PURPOSE OF REVIEW:In this brief review, we highlight studies that have contributed to our current understanding of glucose homeostasis by the central nervous system (CNS) leptin-melanocortin system, particularly proopiomelanocortin neurons and melanocortin-4 receptors (MC4R). RECENT FINDINGS:Leptin deficiency is assoc...

journal_title：Current diabetes reports

authors： da Silva AA,do Carmo JM,Hall JE

更新日期：2020-05-26 00:00:00

abstract：:According to a 2010 national survey, 11 % of adults in China have diabetes, affecting 109.6 million individuals. The high prevalence of diabetes has been attributed to the aging of the population, the rapid adoption of energy-dense foods, and a reduction in physical activity. Collectively, these secular changes have c...

journal_title：Current diabetes reports

authors： Yin J,Kong AP,Chan JC

更新日期：2016-12-01 00:00:00

abstract：:Cardiovascular disease is a leading cause of death and disability in patients with diabetes or metabolic syndrome (MS). The available data suggest that many patients with diabetes or MS already have vascular abnormalities by the time they are diagnosed with their metabolic disorder. Endothelial dysfunction (ED), which...

journal_title：Current diabetes reports

authors： Deedwania PC

更新日期：2003-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 diabetes (T1D) is an autoimmune disease marked by β-cell destruction. Immunotherapies for T1D have been investigated since the 1980s and have focused on restoration of tolerance, T cell or B cell inhibition, regulatory T cell (Treg) induction, suppression of innate immunity and inflammation, im...

journal_title：Current diabetes reports

authors： Bone RN,Evans-Molina C

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:The increasing prevalence of type 2 diabetes is driving the boundaries of clinical diabetes care outside of the traditional office setting. The purpose of this paper will be to review recent technological advances in the medical management of people with type 2 diabetes, spanning the spectrum of care ...

journal_title：Current diabetes reports

authors： Grant AK,Golden L

更新日期：2019-12-20 00:00:00

abstract：:Worldwide increases in diabetes prevalence in the face of limited medical resources have prompted international interest in innovative healthcare delivery models. Project ECHO (Extension for Community Healthcare Outcomes) is a "telementoring" program which has been shown to increase capacity for complex disease manage...

journal_title：Current diabetes reports

authors： Bouchonville MF,Paul MM,Billings J,Kirk JB,Arora S

更新日期：2016-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Soon after the first genome-wide association study (GWAS) for type 2 diabetes (T2D) was published, it was hypothesized that rare and low-frequency variants might explain a substantial proportion of disease risk. Rare coding variants in particular were emphasized given their large expected role in dise...

journal_title：Current diabetes reports

authors： Flannick J

更新日期：2019-04-08 00:00:00

abstract：:The number of available therapies for treating type 2 diabetes has grown considerably in recent years. This growth has been fueled by availability of newer medications, whose benefits and risks have not been fully established. In this study, we review and synthesize the existing literature on the uptake, efficacy, saf...

journal_title：Current diabetes reports

authors： Ahuja V,Chou CH

更新日期：2016-06-01 00:00:00