Recovery of endocrine function after islet and pancreas transplantation.

abstract：PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell bi...

journal_title：Current diabetes reports

authors： Kim J,Kang K,Drogemuller CJ,Wallace GG,Coates PT

更新日期：2019-07-04 00:00:00

abstract：:Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...

journal_title：Current diabetes reports

authors： Durnwald CP,Landon MB

更新日期：2011-02-01 00:00:00

abstract：:As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...

journal_title：Current diabetes reports

authors： Puri R,Kataoka Y,Uno K,Nicholls SJ

更新日期：2012-06-01 00:00:00

abstract：:Pregnancy is susceptible to oxidative stress and antioxidant defenses can be altered in response to elevated levels of oxidative stress. Limited data in gestational diabetes mellitus (GDM) suggest that products of lipid peroxidation may be increased and antioxidant enzyme activities decreased, although the results hav...

journal_title：Current diabetes reports

authors： Chen X,Scholl TO

更新日期：2005-08-01 00:00:00

abstract：:Bariatric surgery has emerged as the most durably effective treatment of type 2 diabetes (DM). However, the mechanisms governing improvement in glucose homeostasis have yet to be fully elucidated. In this review we discuss the various types of surgical interventions and the multitude of factors that potentially mediat...

journal_title：Current diabetes reports

authors： Nguyen KT,Korner J

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Neuropathic pain may arise from multiple mechanisms and locations. Efficacy of current treatments for painful diabetic neuropathy is limited to an unpredictable subset of patients, possibly reflecting diversity of pain generator mechanisms, and there is a lack of targeted treatments for individual pat...

journal_title：Current diabetes reports

authors： Lee-Kubli C,Marshall AG,Malik RA,Calcutt NA

更新日期：2018-01-23 00:00:00

abstract：PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...

journal_title：Current diabetes reports

authors： Honasoge A,Nudleman E,Smith M,Rajagopal R

更新日期：2019-09-10 00:00:00

abstract：PURPOSES OF REVIEW:Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve t...

journal_title：Current diabetes reports

authors： Smink AM,de Vos P

更新日期：2018-05-19 00:00:00

abstract：PURPOSE OF REVIEW:The goal of this review is to provide updates on congenital (neonatal) diabetes from 2011 to present, with an emphasis on publications from 2015 to present. RECENT FINDINGS:There has been continued worldwide progress in uncovering the genetic causes of diabetes presenting within the first year of lif...

journal_title：Current diabetes reports

authors： Letourneau LR,Greeley SAW

更新日期：2018-06-13 00:00:00

abstract：:Diabetes mellitus is a chronic disease with a higher risk of associated infections. HIV infection severely affects diabetic patients and acts as a significant health concern. Highly active antiretroviral therapy (HAART) has changed HIV from an acute infection to a chronic infection with associated significant metaboli...

journal_title：Current diabetes reports

authors： Kalra S,Agrawal N

更新日期：2013-06-01 00:00:00

abstract：:Cardiovascular disease is a leading cause of death and disability in patients with diabetes or metabolic syndrome (MS). The available data suggest that many patients with diabetes or MS already have vascular abnormalities by the time they are diagnosed with their metabolic disorder. Endothelial dysfunction (ED), which...

journal_title：Current diabetes reports

authors： Deedwania PC

更新日期：2003-08-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the treatment of type 2 diabetes from a cardiologist's view. RECENT FINDINGS:A new era in the treatment of type 2 diabetes began for the cardiologist in 2015 with the publication of the EMPA-REG outcome trial finding a significant reduction in CV death with empagliflozin (oral sodium-gluc...

journal_title：Current diabetes reports

authors： Chilton RJ,Gallegos KM,Silva-Cardoso J,Oliveros R,Pham S

更新日期：2018-11-08 00:00:00

abstract：:Low- and middle-income countries (LMICs) face a rapid change in the nutrition transition toward increases in noncommunicable diseases. Underlying this transition are shifts in the agricultural system and the subsequent growth of the modern retail and food service sectors across all regions and countries, a change in t...

journal_title：Current diabetes reports

authors： Popkin BM

更新日期：2015-09-01 00:00:00

abstract：:Over the past 8 years, the genetics of complex traits have benefited from an unprecedented advancement in the identification of common variant loci for diseases such as type 2 diabetes (T2D). The ability to undertake genome-wide association studies in large population-based samples for quantitative glycaemic traits ha...

journal_title：Current diabetes reports

authors： Marullo L,El-Sayed Moustafa JS,Prokopenko I

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...

journal_title：Current diabetes reports

authors： Allweiss P

更新日期：2019-11-20 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease found in 3% to 9% of children in the United States. NAFLD represents a spectrum of liver disease and is frequently associated with features of the metabolic syndrome. Nutrition's role in NAFLD is complex. It does not appear that overweight...

journal_title：Current diabetes reports

authors： Vos MB,McClain CJ

更新日期：2008-10-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a complex chronic disease that has many facets for successful management. The burden of this management falls largely on the individual and their family members. Self-management has a major influence on T1D health outcomes, and with successful management, children and adolescents with T1D can ...

journal_title：Current diabetes reports

authors： Naranjo D,Mulvaney S,McGrath M,Garnero T,Hood K

更新日期：2014-01-01 00:00:00

abstract：:The number of available therapies for treating type 2 diabetes has grown considerably in recent years. This growth has been fueled by availability of newer medications, whose benefits and risks have not been fully established. In this study, we review and synthesize the existing literature on the uptake, efficacy, saf...

journal_title：Current diabetes reports

authors： Ahuja V,Chou CH

更新日期：2016-06-01 00:00:00

abstract：:Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...

journal_title：Current diabetes reports

authors： Karl DM

更新日期：2004-10-01 00:00:00

abstract：:Although a clear relationship exists between glycosylated hemoglobin and cardiovascular (CV) disease in individuals with type 2 diabetes mellitus (T2DM) in epidemiologic studies, data from prospective studies are less clear. Earlier prospective studies examining intensive glucose lowering suffered from a lack of stati...

journal_title：Current diabetes reports

authors： Zarich SW

更新日期：2009-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The oral glucose tolerance test (OGTT) is used both in clinical practice and research to assess glucose tolerance. In addition, the OGTT is utilized for surrogate measures of insulin sensitivity and the insulin response to enteral glucose and has been widely applied in the evaluation of β-cell dysfunc...

journal_title：Current diabetes reports

authors： Chen ME,Aguirre RS,Hannon TS

更新日期：2018-06-16 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 diabetes (T1D) is an autoimmune disease marked by β-cell destruction. Immunotherapies for T1D have been investigated since the 1980s and have focused on restoration of tolerance, T cell or B cell inhibition, regulatory T cell (Treg) induction, suppression of innate immunity and inflammation, im...

journal_title：Current diabetes reports

authors： Bone RN,Evans-Molina C

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Therapies that target beta-cell antigen-specific T cells subsets have not been as successful in patients with type 1 diabetes as in mice. This might be explained by complexities in the repertoire of beta-cell antigen-specific T cells and the variety of T cell subsets involved in type 1 diabetes develo...

journal_title：Current diabetes reports

authors： Narsale A,Davies JD

更新日期：2017-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Soon after the first genome-wide association study (GWAS) for type 2 diabetes (T2D) was published, it was hypothesized that rare and low-frequency variants might explain a substantial proportion of disease risk. Rare coding variants in particular were emphasized given their large expected role in dise...

journal_title：Current diabetes reports

authors： Flannick J

更新日期：2019-04-08 00:00:00

abstract：PURPOSE OF REVIEW:A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Cont...

journal_title：Current diabetes reports

authors： Feldman MA,Anderson LM,Shapiro JB,Jedraszko AM,Evans M,Weil LEG,Garza KP,Weissberg-Benchell J

更新日期：2018-02-19 00:00:00

abstract：:Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for intervention....

journal_title：Current diabetes reports

authors： Adler A

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:In this brief review, we highlight studies that have contributed to our current understanding of glucose homeostasis by the central nervous system (CNS) leptin-melanocortin system, particularly proopiomelanocortin neurons and melanocortin-4 receptors (MC4R). RECENT FINDINGS:Leptin deficiency is assoc...

journal_title：Current diabetes reports

authors： da Silva AA,do Carmo JM,Hall JE

更新日期：2020-05-26 00:00:00

abstract：:Although numerous chemokine/chemokine receptor pathways have been described to be implicated in the pathogenesis of type 1 diabetes (T1D), the CXCR1/2 axis has recently been proved to be crucial for leucocyte recruitment involved in insulitis and β cell damage. Multiple strategies blocking the CXCR1/2 pathway are avai...

journal_title：Current diabetes reports

authors： Citro A,Cantarelli E,Piemonti L

更新日期：2015-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...

journal_title：Current diabetes reports

authors： Khan MS,Vaduganathan M

更新日期：2020-10-11 00:00:00

abstract：:Beta cell replacement therapy has been proposed as a novel therapy for the treatment of type 1 diabetes. The proof of concept has been demonstrated with successful islet allotransplantation. Islet xenotransplantation has been proposed as an alternative, more reliable, and infinite source of beta cells. The advantages ...

journal_title：Current diabetes reports

authors： O'Connell PJ,Cowan PJ,Hawthorne WJ,Yi S,Lew AM

更新日期：2013-10-01 00:00:00