Abstract:
:Over the past 8 years, the genetics of complex traits have benefited from an unprecedented advancement in the identification of common variant loci for diseases such as type 2 diabetes (T2D). The ability to undertake genome-wide association studies in large population-based samples for quantitative glycaemic traits has permitted us to explore the hypothesis that models arising from studies in non-diabetic individuals may reflect mechanisms involved in the pathogenesis of diabetes. Amongst 88 T2D risk and 72 glycaemic trait loci, only 29 are shared and show disproportionate magnitudes of phenotypic effects. Important mechanistic insights have been gained regarding the physiological role of T2D loci in disease predisposition through the elucidation of their contribution to glycaemic trait variability. Further investigation is warranted to define causal variants within these loci, including functional characterisation of associated variants, to dissect their role in disease mechanisms and to enable clinical translation.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Marullo L,El-Sayed Moustafa JS,Prokopenko Idoi
10.1007/s11892-014-0551-8subject
Has Abstractpub_date
2014-01-01 00:00:00pages
551issue
11eissn
1534-4827issn
1539-0829journal_volume
14pub_type
杂志文章,评审abstract::Autonomic dysfunction is a frequent and relevant complication of diabetes mellitus, as it is associated with increased morbidity and mortality. In addition, it is today considered as predictive of the most severe diabetic complications, like nephropathy and retinopathy. The classical methods of screening are the cardi...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0804-9
更新日期:2016-11-01 00:00:00
abstract::Among the spectrum of risk for diabetic foot disease conferred by chronic kidney disease (CKD), end-stage renal disease (ESRD) has emerged as a novel independent risk factor. Apart from the classical triad of neuropathy, infection, and peripheral arterial disease that operate in these individuals, the risk is further ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-010-0128-0
更新日期:2010-08-01 00:00:00
abstract:PURPOSE OF THE REVIEW:In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative properties. RECENT FIN...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01344-6
更新日期:2020-09-28 00:00:00
abstract:PURPOSE OF REVIEW:The Diabetes Prevention Program (DPP) is an evidence-based lifestyle change program for prediabetes that is associated with a 58% reduction in 3-year diabetes incidence, and it has been supported by the American Medical Association and the Centers for Disease Control and Prevention. However, 9 in 10 p...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1034-0
更新日期:2018-08-08 00:00:00
abstract:PURPOSE OF REVIEW:This study aims to examine the operationalisation of 'psychological insulin resistance' (PIR) among people with type 2 diabetes and to identify and critique relevant measures. RECENT FINDINGS:PIR has been operationalised as (1) the assessment of attitudes or beliefs about insulin therapy and (2) hypo...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0873-4
更新日期:2017-07-01 00:00:00
abstract::This review details the epidemiology, possible mechanisms, and risk factors associated with urogenital autonomic dysfunction in diabetes. Autonomic neuropathy in diabetes is associated with various urological complications including bladder and sexual dysfunction. Several studies have reported the high prevalence of b...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0824-5
更新日期:2016-12-01 00:00:00
abstract::As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0270-y
更新日期:2012-06-01 00:00:00
abstract:PURPOSE OF REVIEW:This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS:Problems in cognitive...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-0995-3
更新日期:2018-03-21 00:00:00
abstract:PURPOSE OF REVIEW:Obesity is increasing at an alarming rate and now poses a global threat to humankind. In recent years, we have seen the emergence of medical devices to combat the obesity epidemic. These therapeutic strategies are discussed in this review dividing them into gastric and duodenal therapies. RECENT FIND...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1217-3
更新日期:2019-08-30 00:00:00
abstract::Although numerous chemokine/chemokine receptor pathways have been described to be implicated in the pathogenesis of type 1 diabetes (T1D), the CXCR1/2 axis has recently been proved to be crucial for leucocyte recruitment involved in insulitis and β cell damage. Multiple strategies blocking the CXCR1/2 pathway are avai...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0638-x
更新日期:2015-10-01 00:00:00
abstract::Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-010-0160-0
更新日期:2011-02-01 00:00:00
abstract::Patients with type 1 diabetes (T1D) suffer excess mortality from cardiovascular disease (CVD) that has persisted despite substantial reductions in microvascular complications. Although T1D and type 2 diabetes (T2D) are etiologically distinct, it has generally been assumed that CVD in T1D is "the same disease" as that ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0598-1
更新日期:2015-05-01 00:00:00
abstract:PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyper...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01307-x
更新日期:2020-05-19 00:00:00
abstract:PURPOSE OF REVIEW:Ambient air pollution is strongly linked to cardiovascular and respiratory diseases. We summarize available published evidence regarding similar associations with diabetes across the life course. RECENT FINDINGS:We performed a life-course survey of the recent literature, including prenatal, gestation...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1181-y
更新日期:2019-07-19 00:00:00
abstract:PURPOSE OF REVIEW:To evaluate the treatment of type 2 diabetes from a cardiologist's view. RECENT FINDINGS:A new era in the treatment of type 2 diabetes began for the cardiologist in 2015 with the publication of the EMPA-REG outcome trial finding a significant reduction in CV death with empagliflozin (oral sodium-gluc...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1114-1
更新日期:2018-11-08 00:00:00
abstract::The transition from intravenous (IV) to subcutaneous (SQ) insulin in the hospitalized patient with diabetes or hyperglycemia is a key step in patient care. This review article suggests a stepwise approach to the transition in order to promote safety and euglycemia. Important components of the transition include evalua...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0595-4
更新日期:2015-05-01 00:00:00
abstract:PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01347-3
更新日期:2020-10-11 00:00:00
abstract::Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for intervention....
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-001-0035-5
更新日期:2001-12-01 00:00:00
abstract::The diabetes and obesity epidemics have stimulated research to assess the benefits and potential risks of low-carbohydrate diets. Carbohydrate comprises less than 45% of calories in carbohydrate-restricted diets, but very low carbohydrate ketogenic diets may restrict carbohydrate to 20 g initially with variability in ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-009-0061-2
更新日期:2009-10-01 00:00:00
abstract::Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and acti...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0605-6
更新日期:2015-06-01 00:00:00
abstract::The therapy of type 1 diabetes is an open challenging problem. The restoration of normoglycemia and insulin independence in immunosuppressed type 1 diabetic recipients of islet allotransplantation has shown the potential of a cell-based diabetes therapy. Even if successful, this approach poses a problem of scarce tiss...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-011-0213-z
更新日期:2011-10-01 00:00:00
abstract::Diabetic patients are at increased risk for developing cardiovascular disease, and they constitute a large proportion of the global cardiovascular disease burden. Although multiple drugs exist for treating the hyperglycemia associated with diabetes, few have been shown to reduce cardiovascular risk. Great hope surroun...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-010-0099-1
更新日期:2010-04-01 00:00:00
abstract::Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presenta...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-014-0538-5
更新日期:2014-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1258-7
更新日期:2019-11-20 00:00:00
abstract::Exercise has long been recognized as a cornerstone in diabetes care. Even so, modern science is just beginning to understand the physiologic impact cardiovascular fitness has on long-term diabetes management, and the prevention or delay, of type 2 diabetes. Recent advances in research are defining the metabolic pathwa...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-002-0109-z
更新日期:2002-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell bi...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1166-x
更新日期:2019-07-04 00:00:00
abstract::The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of type 2 diabetes mellitus to the chromosome 1q21-25 region in at least eight independent studies. More than 26 candidate genes have already been evaluated, but to date none explain the evidence for linkage in this gene-dense region....
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-007-0025-3
更新日期:2007-04-01 00:00:00
abstract:PURPOSE OF REVIEW:Diabetic nephropathy, a major microvascular complication of diabetes and the most common cause of end-stage renal disease, is characterized by prominent accumulation of extracellular matrix. The membrane microdomains caveolae, and their integral protein caveolin-1, play critical roles in the regulatio...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0844-9
更新日期:2017-03-01 00:00:00
abstract:PURPOSE OF REVIEW:This review aims to discuss the burden of type 2 diabetes in youth and summarize the studies that have utilized noninvasive techniques to assess early vascular disease in youth with type 2 diabetes. RECENT FINDINGS:Noninvasive imaging modalities provide researchers with tools to investigate the vascu...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-017-0869-0
更新日期:2017-06-01 00:00:00
abstract::According to a 2010 national survey, 11 % of adults in China have diabetes, affecting 109.6 million individuals. The high prevalence of diabetes has been attributed to the aging of the population, the rapid adoption of energy-dense foods, and a reduction in physical activity. Collectively, these secular changes have c...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0821-8
更新日期:2016-12-01 00:00:00