Bile acid sequestrants for lipid and glucose control.

Abstract:

:Bile acids are generated in the liver and are traditionally recognized for their regulatory role in multiple metabolic processes including bile acid homeostasis, nutrient absorption, and cholesterol homeostasis. Recently, bile acids emerged as signaling molecules that, as ligands for the bile acid receptors farnesoid X receptor (FXR) and TGR5, activate and integrate multiple complex signaling pathways involved in lipid and glucose metabolism. Bile acid sequestrants are pharmacologic molecules that bind to bile acids in the intestine resulting in the interruption of bile acid homeostasis and, consequently, reduction in low-density lipoprotein cholesterol levels in hypercholesterolemia. Bile acid sequestrants also reduce glucose levels and improve glycemic control in persons with type 2 diabetes mellitus (T2DM). This article examines the mechanisms by which bile acid-mediated activation of FXR and TGR5 signaling pathways regulate lipid and glucose metabolism and the potential implications for bile acid sequestrant-mediated regulation of lipid and glucose levels in T2DM.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Staels B,Handelsman Y,Fonseca V

doi

10.1007/s11892-009-0087-5

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

70-7

issue

1

eissn

1534-4827

issn

1539-0829

journal_volume

10

pub_type

杂志文章
  • Pathophysiology of prediabetes.

    abstract::The term prediabetes refers to subjects with impaired fasting glucose and/or impaired glucose tolerance who are at increased risk for type 2 diabetes mellitus. Although both types of patients are at increased risk for developing type 2 diabetes mellitus and cardiovascular disease, they manifest distinct metabolic abno...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-009-0032-7

    authors: Abdul-Ghani MA,DeFronzo RA

    更新日期:2009-06-01 00:00:00

  • Diabetic Eye Screening: Knowledge and Perspectives from Providers and Patients.

    abstract:PURPOSE OF REVIEW:Diabetic retinopathy remains the leading cause of blindness among working-age US adults even though timely screening and treatment prevent 90% of blindness. We summarize current knowledge and perspectives to better understand why diabetic eye screening rates remain low and future directions towards pr...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-017-0911-2

    authors: Liu Y,Swearingen R

    更新日期:2017-08-31 00:00:00

  • Maternal factors that determine neonatal size and body fat.

    abstract::These data are a review of previously published data. Initially, body composition was estimated in 186 neonates. Fat- free mass (FFM), which constituted 86% of birth weight, accounted for 83% of the variance in birth weight; fat mass (FM), which constituted 14% of birth weight, accounted for 46% of the variance in bir...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-001-0013-y

    authors: Catalano PM,Kirwan JP

    更新日期:2001-08-01 00:00:00

  • Brain Stimulation to Modulate Food Intake and Eating Behavior.

    abstract:PURPOSE OF REVIEW:Appetitive behaviors are mediated through homeostatic and reward signaling of brain circuits. There has been increasing interest in the use of neuromodulation techniques aimed at targeting brain regions such as the lateral prefrontal and subcortical regions associated with dysregulation of eating beha...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1250-2

    authors: Dendy R,Stinson EJ,Guerithault N,Gluck ME

    更新日期:2019-12-02 00:00:00

  • The Charcot foot: medical and surgical therapy.

    abstract::Charcot neuro-osteoarthropathy (CN) is among the most devastating complications of neuropathy and now most commonly occurs in the feet of diabetic patients. Because it is relatively rare and because most patients and practitioners do not expect major bone pathology in the absence of significant pain, CN is often misdi...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-008-0077-z

    authors: Ulbrecht JS,Wukich DK

    更新日期:2008-12-01 00:00:00

  • Mechanisms of endothelial dysfunction in the metabolic syndrome.

    abstract::Cardiovascular disease is a leading cause of death and disability in patients with diabetes or metabolic syndrome (MS). The available data suggest that many patients with diabetes or MS already have vascular abnormalities by the time they are diagnosed with their metabolic disorder. Endothelial dysfunction (ED), which...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-003-0019-8

    authors: Deedwania PC

    更新日期:2003-08-01 00:00:00

  • Cardiometabolic Morbidity and Mortality with Smoking Cessation, Review of Recommendations for People with Diabetes and Obesity.

    abstract:PURPOSE OF REVIEW:Obesity is closely linked with the pathogenesis of type 2 diabetes (T2DM) and cardiovascular disease (CVD), and whilst smoking cessation is associated with weight gain, there are concerns that this weight gain may offset the benefit of CVD risk reduction especially in those with considerable post-cess...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01352-6

    authors: Kos K

    更新日期:2020-12-08 00:00:00

  • No islets left behind: islet autotransplantation for surgery-induced diabetes.

    abstract::For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preser...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-012-0296-1

    authors: Bellin MD,Balamurugan AN,Pruett TL,Sutherland DE

    更新日期:2012-10-01 00:00:00

  • Effectiveness of diabetes interventions in the patient-centered medical home.

    abstract::The patient-centered medical home (PCMH) is an innovative care model for the provision of primary care that is being rapidly adopted in the U.S. with the support of federal agencies and professional organizations. Its goal is to provide comprehensive, patient-centered care with increased access, quality, and efficienc...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0471-z

    authors: Ackroyd SA,Wexler DJ

    更新日期:2014-03-01 00:00:00

  • What type of diabetes do young people have?

    abstract::Although type 1 diabetes remains the most common type of diabetes in the pediatric population, there has been a dramatic rise in type 2 diabetes in youth. Clinical distinctions between these two major types have become blurred. As genetic and biochemical measures become more affordable and available, practical applica...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-006-0020-0

    authors: Pihoker C

    更新日期:2006-04-01 00:00:00

  • Impact of hypoglycemia in hospitalized patients.

    abstract::Hypoglycemia is a common problem in hospitalized patients, particularly the elderly, frail, and severely ill. Hypoglycemia has been implicated in the development of adverse clinical outcomes, including increased mortality. Fear of iatrogenic hypoglycemia remains an obstacle to adequate inpatient glycemic control. Howe...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-012-0336-x

    authors: Carey M,Boucai L,Zonszein J

    更新日期:2013-02-01 00:00:00

  • Role of Senescent Renal Cells in Pathophysiology of Diabetic Kidney Disease.

    abstract:PURPOSE OF REVIEW:Diabetic kidney disease (DKD) is the leading cause of kidney failure in the USA, representing ~ 44% of all cases of kidney failure. Advancements in both glucose management and inhibitors of the renin-angiotensin system have significantly improved prognosis for individuals with DKD, yet DKD continues t...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01314-y

    authors: Wiley CD

    更新日期:2020-06-16 00:00:00

  • Drugs on the horizon for diabesity.

    abstract::The coexistence of type 2 diabetes and obesity presents a complex therapeutic challenge. Future combination tablets may include agents to address diabetes and any accompanying cardiovascular risk factors. Injectable agents that improve glycemic control and facilitate weight loss have recently become available: the sol...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-005-0093-1

    authors: Bailey CJ

    更新日期:2005-10-01 00:00:00

  • Diabetic Kidney Disease: Is There a Role for Glycemic Variability?

    abstract:PURPOSE OF REVIEW:Diabetes is the leading cause of kidney disease globally. Diabetic kidney disease (DKD) is a heterogeneous disorder manifested as albuminuria and/or decreasing GFR. Hyperglycemic burden is the major contributor to the development of DKD. In this article, we review the evidence for the contribution of ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-018-0979-3

    authors: Subramanian S,Hirsch IB

    更新日期:2018-02-15 00:00:00

  • Mobile Phone and Smartphone Technologies for Diabetes Care and Self-Management.

    abstract::Mobile and smartphone (mHealth) technologies have the potential to improve diabetes care and self-management, but little is known about their effectiveness and how patients, providers, and payers currently interact with them. We conducted a systematic review and found only 20 peer-reviewed articles, published since 20...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0680-8

    authors: Garabedian LF,Ross-Degnan D,Wharam JF

    更新日期:2015-12-01 00:00:00

  • Is the risk and nature of CVD the same in type 1 and type 2 diabetes?

    abstract::The incidence of both type 1 and type 2 diabetes is increasing globally, most likely explained by environmental changes, such as changing exposures to foods, viruses, and toxins, and by increasing obesity. While cardiovascular disease (CVD) mortality has been declining recently, this global epidemic of diabetes threat...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0380-1

    authors: Duca L,Sippl R,Snell-Bergeon JK

    更新日期:2013-06-01 00:00:00

  • The use of bolus insulin and advancing insulin therapy in type 2 diabetes.

    abstract::Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-004-0037-1

    authors: Karl DM

    更新日期:2004-10-01 00:00:00

  • Diagnostic Strategies for Gestational Diabetes Mellitus: Review of Current Evidence.

    abstract:PURPOSE OF REVIEW:Currently, the diagnosis of gestational diabetes mellitus (GDM) lacks uniformity. Several controversies are still under debate, especially on the method of screening and diagnosis. This review focuses on recent literature and provides current evidence for the screening and diagnosis of GDM. RECENT FI...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1271-x

    authors: Kuo CH,Li HY

    更新日期:2019-12-04 00:00:00

  • Diabetes and Cognitive Impairment.

    abstract::Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are fur...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0775-x

    authors: Zilliox LA,Chadrasekaran K,Kwan JY,Russell JW

    更新日期:2016-09-01 00:00:00

  • Breast-feeding and diabetes: long-term impact on mothers and their infants.

    abstract::In the general population, breast-feeding is associated with a reduced risk of the offspring being overweight later in life by 22% to 24% across the age spectrum, from preschool children to adults. There is a dose-response gradient with increasing duration of breast-feeding, and lowest risk with prolonged, exclusive b...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-008-0050-x

    authors: Gunderson EP

    更新日期:2008-08-01 00:00:00

  • Latent (slowly progressing) autoimmune diabetes in adults.

    abstract::About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and m...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-008-0018-x

    authors: Seissler J

    更新日期:2008-04-01 00:00:00

  • Alginate-based encapsulation of cells: past, present, and future.

    abstract::Replacing dysfunctional endocrine tissues (eg, islets) with healthy, nonautologous material protected against the immune defense of the patient could soon become a reality. Recent advances have resulted in the development of alginate-based microcapsules that meet the demands of biocompatibility, long-term integrity, a...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-007-0051-1

    authors: Zimmermann H,Shirley SG,Zimmermann U

    更新日期:2007-08-01 00:00:00

  • Genetic and Environmental Interaction in Type 1 Diabetes: a Relationship Between Genetic Risk Alleles and Molecular Traits of Enterovirus Infection?

    abstract:PURPOSE OF REVIEW:We provide an overview of the current knowledge regarding the natural history of human type 1 diabetes (T1D) and the documented associations between virus infections (in particular the enteroviruses) and disease development. We review studies that examine whether T1D-specific risk alleles in genes inv...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1192-8

    authors: Blanter M,Sork H,Tuomela S,Flodström-Tullberg M

    更新日期:2019-08-10 00:00:00

  • Marijuana Use and Type 2 Diabetes Mellitus: a Review.

    abstract::Marijuana is used by millions of people, with use likely to increase in the USA because of the trend towards increased decriminalization and legalization. Obesity and diabetes mellitus (DM) rates have increased dramatically in the USA over the past 30 years, with a recent estimate of 29 million individuals with DM. Be...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0795-6

    authors: Sidney S

    更新日期:2016-11-01 00:00:00

  • The potential of cell-based therapy for diabetes and diabetes-related vascular complications.

    abstract::Cell therapy has enormous potential for the treatment of conditions of unmet medical need. Cell therapy may be applied to diabetes mellitus in the context of beta cell replacement or for the treatment of diabetic complications. A large number of cell types including hematopoietic stem cells, mesenchymal stem cells, um...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0469-6

    authors: Liew A,O'Brien T

    更新日期:2014-03-01 00:00:00

  • Diabetes and HIV: current understanding and future perspectives.

    abstract::Diabetes mellitus is a chronic disease with a higher risk of associated infections. HIV infection severely affects diabetic patients and acts as a significant health concern. Highly active antiretroviral therapy (HAART) has changed HIV from an acute infection to a chronic infection with associated significant metaboli...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-013-0369-9

    authors: Kalra S,Agrawal N

    更新日期:2013-06-01 00:00:00

  • Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes.

    abstract::Type 1 and type 2 diabetes both accelerate cardiovascular disease, yet the triggers are likely different for the two types of diabetes. Results from large-scale clinical trials suggest that intense blood glucose control can reduce cardiovascular events many years later in patients with type 1 diabetes. In type 2 diabe...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-009-0005-x

    authors: Averill MM,Bornfeldt KE

    更新日期:2009-02-01 00:00:00

  • Endothelium, inflammation, and diabetes.

    abstract::The endothelium has several diverse functions in maintaining vascular integrity in terms of structure and function. Two key vasodilators, nitric oxide (NO) and prostacyclin, maintain the vascular pathway, inhibit platelet aggregation, and are antithrombotic. More recently, they have been shown to be anti-inflammatory,...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-002-0019-0

    authors: Dandona P

    更新日期:2002-08-01 00:00:00

  • Progression of β-cell dysfunction in obese youth.

    abstract::The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-012-0347-7

    authors: Giannini C,Caprio S

    更新日期:2013-02-01 00:00:00

  • Diabetes group visits: integrated medical care and behavioral support to improve diabetes care and outcomes from a primary care perspective.

    abstract::Of the many innovations in health care delivery proposed in the context of health reform for those with chronic diseases such as diabetes, the group visit model is relatively easy to implement and is effective for improving health outcomes and patient and provider satisfaction, with a neutral to positive effect on hea...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-012-0349-5

    authors: Eisenstat SA,Ulman K,Siegel AL,Carlson K

    更新日期:2013-04-01 00:00:00