Abstract：
PURPOSE OF REVIEW:We provide an overview of the current knowledge regarding the natural history of human type 1 diabetes (T1D) and the documented associations between virus infections (in particular the enteroviruses) and disease development. We review studies that examine whether T1D-specific risk alleles in genes involved in the function of the immune system can alter susceptibility to virus infections or affect the magnitude of the host antiviral response. We also highlight where the major gaps in our knowledge exist and consider possible implications that new insights gained from the discussed gene-environment interaction studies may bring. RECENT FINDINGS:A commonality between several of the studied T1D risk variants studied is their role in modulating the host immune response to viral infection. Generally, little support exists indicating that the risk variants increase susceptibility to infection and moreover, they usually appear to predispose the immune system towards a hyper-reactive state, decrease the risk of infection, and/or favor the establishment of viral persistence. In conclusion, although the current number of studies is limited, this type of research can provide important insights into the mechanisms that are central to disease pathogenesis and further describe how genetic and environmental factors jointly influence the risk of T1D development. The latter may provide genetic markers that could be used for patient stratification and for the selection of method(s) for disease prevention.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Blanter M,Sork H,Tuomela S,Flodström-Tullberg Mdoi
10.1007/s11892-019-1192-8subject
Has Abstractpub_date
2019-08-10 00:00:00pages
82issue
9eissn
1534-4827issn
1539-0829pii
10.1007/s11892-019-1192-8journal_volume
19pub_type
杂志文章,评审abstract：:Diabetic nephropathy has become the main cause of renal failure, but unfortunately the intimate mechanisms leading to the development and progression of renal injury are not yet fully known. Activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes. Moreover, different inflammator...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-006-0080-1
更新日期：2006-12-01 00:00:00
abstract：PURPOSE OF REVIEW:This study aims to examine the operationalisation of 'psychological insulin resistance' (PIR) among people with type 2 diabetes and to identify and critique relevant measures. RECENT FINDINGS:PIR has been operationalised as (1) the assessment of attitudes or beliefs about insulin therapy and (2) hypo...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-017-0873-4
更新日期：2017-07-01 00:00:00
abstract：PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell bi...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1166-x
更新日期：2019-07-04 00:00:00
abstract：:Diabetes mellitus is a chronic disease with a higher risk of associated infections. HIV infection severely affects diabetic patients and acts as a significant health concern. Highly active antiretroviral therapy (HAART) has changed HIV from an acute infection to a chronic infection with associated significant metaboli...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-013-0369-9
更新日期：2013-06-01 00:00:00
abstract：:The prevalence of diabetes is two- to threefold higher in American Indians in Montana compared with the non-Indian population. High rates of diabetes have also been described in Canadian aboriginal populations closely related to the tribes in Montana. Diabetes in pregnancy has increased among Indian mothers and high-b...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-004-0028-2
更新日期：2004-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Diabetic kidney disease (DKD) is the leading cause of kidney failure in the USA, representing ~ 44% of all cases of kidney failure. Advancements in both glucose management and inhibitors of the renin-angiotensin system have significantly improved prognosis for individuals with DKD, yet DKD continues t...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-020-01314-y
更新日期：2020-06-16 00:00:00
abstract：PURPOSE OF REVIEW:Obesity is increasing at an alarming rate and now poses a global threat to humankind. In recent years, we have seen the emergence of medical devices to combat the obesity epidemic. These therapeutic strategies are discussed in this review dividing them into gastric and duodenal therapies. RECENT FIND...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1217-3
更新日期：2019-08-30 00:00:00
abstract：:Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectiv...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-013-0364-1
更新日期：2013-04-01 00:00:00
abstract：:Replacing dysfunctional endocrine tissues (eg, islets) with healthy, nonautologous material protected against the immune defense of the patient could soon become a reality. Recent advances have resulted in the development of alginate-based microcapsules that meet the demands of biocompatibility, long-term integrity, a...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-007-0051-1
更新日期：2007-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Obesity in the older adult is a burgeoning health epidemic that leads to increased morbidity, disability, and institutionalization. This review presents a brief overview of geriatric-specific consequences of obesity by highlighting the risks and benefits of intentional weight loss. RECENT FINDINGS:In...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1249-8
更新日期：2019-11-04 00:00:00
abstract：:Hyperglycemia and dyslipidemia are significant and independent risk factors for the vascular complications in patients with diabetes. They have been suggested to cause cardiovascular pathologic changes in diabetic states through the following molecular mechanisms: formation and accumulation of advanced glycation end p...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-005-0034-z
更新日期：2005-04-01 00:00:00
abstract：:Overnutrition is a major cause of diabetes. The contrary situation of undernutrition has also been suggested to increase the risk of the disease. Especially undernutrition during prenatal life has been hypothesized to program the structure and physiology of the fetus in such a way that it is more prone to develop diab...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0536-7
更新日期：2014-10-01 00:00:00
abstract：:Type 1 diabetes (T1D) is a complex chronic disease that has many facets for successful management. The burden of this management falls largely on the individual and their family members. Self-management has a major influence on T1D health outcomes, and with successful management, children and adolescents with T1D can ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0544-7
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:To provide an updated summary of discoveries made to date resulting from genome-wide association study (GWAS) and sequencing studies, and to discuss the latest loci added to the growing repertoire of genetic signals predisposing to type 1 diabetes (T1D). RECENT FINDINGS:Genetic studies have identifie...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1235-1
更新日期：2019-11-04 00:00:00
abstract：:Beta cell replacement therapy has been proposed as a novel therapy for the treatment of type 1 diabetes. The proof of concept has been demonstrated with successful islet allotransplantation. Islet xenotransplantation has been proposed as an alternative, more reliable, and infinite source of beta cells. The advantages ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-013-0413-9
更新日期：2013-10-01 00:00:00
abstract：:Only 21 % of adolescents with type 1 diabetes (T1D) meet glycemic goals set forth by the American Diabetes Association. Adherence to therapy is a particular concern in this population, and the association between poor adherence and worsening glycemic control indicates that there is a critical need to improve adherence...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-015-0621-6
更新日期：2015-08-01 00:00:00
abstract：PURPOSES OF REVIEW:Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve t...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1014-4
更新日期：2018-05-19 00:00:00
abstract：:Although there is clear evidence from experimental diabetic neuropathy (DN) models that the multiple pathways involved in neuronal degeneration cause overproduction of reactive oxygen species, oxidative stress, and cellular dysfunction, therapeutic approaches addressing these mechanisms have not yet provided a basis f...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-003-0007-z
更新日期：2003-12-01 00:00:00
abstract：:In this article, we introduce the increasing prevalence of type 2 diabetes in the Japanese population and discuss the reasons for such an explosive increase. Diabetes has been brought into prominence in Japan by enhanced insulin resistance, through the change of lifestyle against the background of fragile beta-cell fu...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-005-0013-4
更新日期：2005-06-01 00:00:00
abstract：PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1258-7
更新日期：2019-11-20 00:00:00
abstract：PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1243-1
更新日期：2019-12-06 00:00:00
abstract：:The treatment of painful diabetic polyneuropathy (PDPN) remains a major challenge. A number of reasons have made the guidelines on PDPN management of particular interest, including its high prevalence, health and socioeconomic impact, interdisciplinary nature and the need for updated evidence-based information to refi...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-012-0287-2
更新日期：2012-08-01 00:00:00
abstract：:Among the spectrum of risk for diabetic foot disease conferred by chronic kidney disease (CKD), end-stage renal disease (ESRD) has emerged as a novel independent risk factor. Apart from the classical triad of neuropathy, infection, and peripheral arterial disease that operate in these individuals, the risk is further ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-010-0128-0
更新日期：2010-08-01 00:00:00
abstract：:Hypoglycemia is a frequent occurrence in children and adolescents with type 1 diabetes. A variety of efforts have been made to standardize the definition of hypoglycemia and to define one of its most significant psychosocial consequences-fear of hypoglycemia (FOH). In addition to documenting the experience of FOH in c...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0762-2
更新日期：2016-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Validated thermodynamic energy balance models that predict weight change are ever more in use today. Delivery of model predictions using web-based applets and/or smart phones has transformed these models into viable clinical tools. Here, we provide the general framework for thermodynamic energy balanc...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1207-5
更新日期：2019-08-31 00:00:00
abstract：:The early improvement of glucose control taking place shortly after gastric bypass surgery in obese diabetic patients has long been mysterious. A recent study in mice has highlighted some specific mechanisms underlying this phenomenon. The specificity of gastric bypass in obese diabetic mice relates to major changes i...
journal_title：Current diabetes reports
pub_type： 杂志文章
doi：10.1007/s11892-012-0257-8
更新日期：2012-04-01 00:00:00
abstract：:Diabetes is a common complication of cystic fibrosis (CF), occurring in approximately 40% of adult patients. It is clinically distinct from type 1 or type 2 diabetes, and requires a unique approach. Because of evidence that it is associated with increased morbidity and mortality, prompt diagnosis and aggressive manage...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-002-0069-3
更新日期：2002-04-01 00:00:00
abstract：:These data are a review of previously published data. Initially, body composition was estimated in 186 neonates. Fat- free mass (FFM), which constituted 86% of birth weight, accounted for 83% of the variance in birth weight; fat mass (FM), which constituted 14% of birth weight, accounted for 46% of the variance in bir...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-001-0013-y
更新日期：2001-08-01 00:00:00
abstract：:Fasting glucose and hemoglobin A1c (HbA1c) are the standard measures for diagnosis and monitoring of diabetes. There has been recent interest in nontraditional markers of hyperglycemia, including fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG), as alternatives or adjuncts to standard measures. There i...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0548-3
更新日期：2014-01-01 00:00:00
abstract：PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-020-01347-3
更新日期：2020-10-11 00:00:00
