Lipids versus glucose in inflammation and the pathogenesis of macrovascular disease in diabetes.

Abstract:

:Type 1 and type 2 diabetes both accelerate cardiovascular disease, yet the triggers are likely different for the two types of diabetes. Results from large-scale clinical trials suggest that intense blood glucose control can reduce cardiovascular events many years later in patients with type 1 diabetes. In type 2 diabetes, mechanisms related to insulin resistance and obesity may be more prominent in promoting atherosclerosis. In this article, we discuss the potential effects of hyperglycemia and diabetes-induced lipid abnormalities on atherosclerosis, particularly focusing on advanced stages of atherosclerosis and evidence from mouse models. In addition, we discuss new research findings in monocyte/macrophage biology that may present intriguing new areas of research related to diabetes and atherosclerosis.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Averill MM,Bornfeldt KE

doi

10.1007/s11892-009-0005-x

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

18-25

issue

1

eissn

1534-4827

issn

1539-0829

journal_volume

9

pub_type

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