The Role and Potential Therapeutic Implications of the Fibroblast Growth Factors in Energy Balance and Type 2 Diabetes.

abstract：:The occurrence and progression of nephropathy associated with early onset type 2 diabetes (T2D) is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emerge...

journal_title：Current diabetes reports

authors： Solis-Herrera C,Triplitt CL,Lynch JL

更新日期：2014-02-01 00:00:00

abstract：:Proliferative diabetic retinopathy (PDR), characterized by pathologic retinal angiogenesis, is a major cause of blindness in the USA and globally. Treatments targeting vascular endothelial growth factor (VEGF) have emerged as a beneficial part of the therapeutic armamentarium for this condition, highlighting the utili...

journal_title：Current diabetes reports

authors： Wang S,Park JK,Duh EJ

更新日期：2012-08-01 00:00:00

abstract：:Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for intervention....

journal_title：Current diabetes reports

authors： Adler A

更新日期：2001-12-01 00:00:00

abstract：:Diabetic patients are at increased risk for developing cardiovascular disease, and they constitute a large proportion of the global cardiovascular disease burden. Although multiple drugs exist for treating the hyperglycemia associated with diabetes, few have been shown to reduce cardiovascular risk. Great hope surroun...

journal_title：Current diabetes reports

authors： Lieb DC,McCall AL

更新日期：2010-04-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by the loss of beta-cell secretory function and mass. The pathophysiology of beta-cell failure in T2DM involves a complex interaction between genetic susceptibilities and environmental risk factors. One environmental condition that is gaining...

journal_title：Current diabetes reports

authors： Rakshit K,Thomas AP,Matveyenko AV

更新日期：2014-04-01 00:00:00

abstract：:Cardiovascular disease is a significant cause of morbidity and mortality in patients with diabetes mellitus (DM). DM is now recognized as a risk equivalent for coronary heart disease. The lipid profile in patients with type 2 DM is characterized by elevated triglycerides, low levels of high-density lipoprotein cholest...

journal_title：Current diabetes reports

authors： Gadi R,Samaha FF

更新日期：2007-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review clinical characteristics of pediatric type 2 diabetes in Japan. RECENT FINDINGS:It is well recognized that Asian populations, particularly the Japanese, have a higher incidence of childhood type 2 diabetes. Of note, most Asian populations show a higher incidence of pediatric type 2 diabetes...

journal_title：Current diabetes reports

authors： Urakami T

更新日期：2018-04-18 00:00:00

abstract：:The common form of hereditary hemochromatosis is an autosomal recessive disorder most prevalent in Caucasians that results in excessive iron storage. The clinical manifestations of hemochromatosis are protean. HFE genotype, which determines the degree of iron overload and duration of disease have profound effects on d...

journal_title：Current diabetes reports

authors： Creighton Mitchell T,McClain DA

更新日期：2014-01-01 00:00:00

abstract：:Charcot neuro-osteoarthropathy (CN) is among the most devastating complications of neuropathy and now most commonly occurs in the feet of diabetic patients. Because it is relatively rare and because most patients and practitioners do not expect major bone pathology in the absence of significant pain, CN is often misdi...

journal_title：Current diabetes reports

authors： Ulbrecht JS,Wukich DK

更新日期：2008-12-01 00:00:00

abstract：:For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preser...

journal_title：Current diabetes reports

authors： Bellin MD,Balamurugan AN,Pruett TL,Sutherland DE

更新日期：2012-10-01 00:00:00

abstract：:The therapy of type 1 diabetes is an open challenging problem. The restoration of normoglycemia and insulin independence in immunosuppressed type 1 diabetic recipients of islet allotransplantation has shown the potential of a cell-based diabetes therapy. Even if successful, this approach poses a problem of scarce tiss...

journal_title：Current diabetes reports

authors： Marigliano M,Bertera S,Grupillo M,Trucco M,Bottino R

更新日期：2011-10-01 00:00:00

abstract：:Maintaining normal blood glucose levels is a constant challenge for women with diabetes. Anecdotal reports reveal that many women question if menstrual cycle phases may affect their blood glucose levels. However, results from studies investigating the effect of the menstrual cycle on insulin sensitivity in diabetic wo...

journal_title：Current diabetes reports

authors： Trout KK,Teff KL

更新日期：2004-08-01 00:00:00

abstract：:In normal physiology, glucagon from pancreatic alpha cells plays an important role in maintaining glucose homeostasis via its regulatory effect on hepatic glucose production. Patients with type 2 diabetes suffer from fasting and postprandial hyperglucagonemia, which stimulate hepatic glucose production and, thus, cont...

journal_title：Current diabetes reports

authors： Lund A,Bagger JI,Christensen M,Knop FK,Vilsbøll T

更新日期：2014-12-01 00:00:00

abstract：:Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...

journal_title：Current diabetes reports

authors： Durnwald CP,Landon MB

更新日期：2011-02-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...

journal_title：Current diabetes reports

authors： Allweiss P

更新日期：2019-11-20 00:00:00

abstract：:A large body of evidence indicates that the risk for developing chronic diabetic complications is under the control of genetic factors. Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropath...

journal_title：Current diabetes reports

authors： Doria A

更新日期：2010-12-01 00:00:00

abstract：:The cardiovascular risk associated with the polycystic ovary syndrome (PCOS) has recently attracted much interest. Women with PCOS are more likely to fulfill the diagnosis of the metabolic syndrome, a cluster of related cardiometabolic factors known to predict long-term risk of cardiovascular disease and type 2 diabet...

journal_title：Current diabetes reports

authors： Cussons AJ,Stuckey BG,Watts GF

更新日期：2007-02-01 00:00:00

abstract：:Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...

journal_title：Current diabetes reports

authors： Karl DM

更新日期：2004-10-01 00:00:00

abstract：:Among the factors predisposing to type 2 diabetes in children, adolescents, and young adults, the health and behavior of both the mother and father are critical. Prevention and treatment of parental nutritional disorders (including obesity and malnutrition), promotion of breastfeeding, and avoidance of overfeeding of ...

journal_title：Current diabetes reports

authors： Bartz S,Freemark M

更新日期：2012-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The increasing prevalence of type 2 diabetes is driving the boundaries of clinical diabetes care outside of the traditional office setting. The purpose of this paper will be to review recent technological advances in the medical management of people with type 2 diabetes, spanning the spectrum of care ...

journal_title：Current diabetes reports

authors： Grant AK,Golden L

更新日期：2019-12-20 00:00:00

abstract：:Diabetes mellitus is a chronic disease with a higher risk of associated infections. HIV infection severely affects diabetic patients and acts as a significant health concern. Highly active antiretroviral therapy (HAART) has changed HIV from an acute infection to a chronic infection with associated significant metaboli...

journal_title：Current diabetes reports

authors： Kalra S,Agrawal N

更新日期：2013-06-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current evidence of the safety and efficacy of the use of oral agents for treatment of gestational diabetes (GDM). RECENT FINDINGS:The use of metformin and glyburide in pregnancy for treatment of GDM has dramatically increased since the early 2000s. Meta-analyses suggest that glyburide ...

journal_title：Current diabetes reports

authors： Finneran MM,Landon MB

更新日期：2018-09-28 00:00:00

abstract：:Diabetes is a common complication of cystic fibrosis (CF), occurring in approximately 40% of adult patients. It is clinically distinct from type 1 or type 2 diabetes, and requires a unique approach. Because of evidence that it is associated with increased morbidity and mortality, prompt diagnosis and aggressive manage...

journal_title：Current diabetes reports

authors： Moran A

更新日期：2002-04-01 00:00:00

abstract：:The patient-centered medical home (PCMH) is an innovative care model for the provision of primary care that is being rapidly adopted in the U.S. with the support of federal agencies and professional organizations. Its goal is to provide comprehensive, patient-centered care with increased access, quality, and efficienc...

journal_title：Current diabetes reports

authors： Ackroyd SA,Wexler DJ

更新日期：2014-03-01 00:00:00

abstract：:Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and acti...

journal_title：Current diabetes reports

authors： Dube S,Errazuriz-Cruzat I,Basu A,Basu R

更新日期：2015-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Type 1 diabetes (T1D) is an autoimmune disease marked by β-cell destruction. Immunotherapies for T1D have been investigated since the 1980s and have focused on restoration of tolerance, T cell or B cell inhibition, regulatory T cell (Treg) induction, suppression of innate immunity and inflammation, im...

journal_title：Current diabetes reports

authors： Bone RN,Evans-Molina C

更新日期：2017-07-01 00:00:00

abstract：:Neuropathic pain is responsible for a significant amount of the morbidity associated with generalized and focal peripheral neuropathies in diabetes. It is a consequence of alterations in neuronal function, chemistry, and structure that occur secondary to nerve injury. A variety of agents from diverse pharmacologic cla...

journal_title：Current diabetes reports

authors： Freeman R

更新日期：2005-12-01 00:00:00

abstract：PURPOSE OF THE REVIEW:In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative properties. RECENT FIN...

journal_title：Current diabetes reports

authors： Mantzouratou P,Lavecchia AM,Novelli R,Xinaris C

更新日期：2020-09-28 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. RECENT FINDINGS:Generation of multi-omic data to measure each of the "biologic layers," developments in describing genomic function an...

journal_title：Current diabetes reports

authors： Lin Y,Wessel J

更新日期：2019-02-26 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to discuss the burden of type 2 diabetes in youth and summarize the studies that have utilized noninvasive techniques to assess early vascular disease in youth with type 2 diabetes. RECENT FINDINGS:Noninvasive imaging modalities provide researchers with tools to investigate the vascu...

journal_title：Current diabetes reports

authors： Shah AS,Urbina EM

更新日期：2017-06-01 00:00:00