The Continuing Evolution of Precision Health in Type 2 Diabetes: Achievements and Challenges.

Abstract:

PURPOSE OF REVIEW:The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. RECENT FINDINGS:Generation of multi-omic data to measure each of the "biologic layers," developments in describing genomic function and annotation in T2D relevant tissue, along with the increasing recognition that T2D is a heterogeneous disease, and large-scale collaborations have all contributed to advancing our understanding of the molecular basis of T2D. Substantial advances have been made in understanding the molecular basis of T2D pathogenesis, such that precision health diabetes is increasingly becoming a reality. For precision diabetes to become a routine in clinical and public health, additional large-scale multi-omic initiatives are needed along with better assessment of our environment to delineate an individual's diabetes subtype for improved detection and management.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Lin Y,Wessel J

doi

10.1007/s11892-019-1137-2

subject

Has Abstract

pub_date

2019-02-26 00:00:00

pages

16

issue

4

eissn

1534-4827

issn

1539-0829

pii

10.1007/s11892-019-1137-2

journal_volume

19

pub_type

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