Metabolic syndrome and cardiometabolic risk in PCOS.

abstract：PURPOSE OF REVIEW:Type 2 diabetes is common, burdensome, and preventable. Landmark trials such as the Diabetes Prevention Program (DPP) demonstrated that resource-intensive lifestyle support interventions resulting in modest weight loss via healthy diet changes and physical activity can lower the rate of diabetes devel...

journal_title：Current diabetes reports

authors： Ackermann RT,O'Brien MJ

更新日期：2020-02-20 00:00:00

abstract：:National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...

journal_title：Current diabetes reports

authors： Carson JA

更新日期：2003-10-01 00:00:00

abstract：PURPOSE OF REVIEW:We provide an overview of the current knowledge regarding the natural history of human type 1 diabetes (T1D) and the documented associations between virus infections (in particular the enteroviruses) and disease development. We review studies that examine whether T1D-specific risk alleles in genes inv...

journal_title：Current diabetes reports

authors： Blanter M,Sork H,Tuomela S,Flodström-Tullberg M

更新日期：2019-08-10 00:00:00

abstract：:Insulin analogues were designed to provide more physiologic pharmacokinetic and pharmacodynamic properties compared with human insulin. This article examines the literature over a 2-year period, focusing on studies directly comparing analogue and human insulin in controlled clinical trials and large observational stud...

journal_title：Current diabetes reports

authors： Freeman JS

更新日期：2010-06-01 00:00:00

abstract：PURPOSE OF REVIEW:Obesity and its associated metabolic diseases have reached epidemic proportions worldwide, reducing life expectancy and quality of life. Several drugs have been tested to treat these diseases but many of them have damaging side effects. Consequently, there is an urgent need to develop more effective t...

journal_title：Current diabetes reports

authors： Izaguirre M,Gil MJ,Monreal I,Montecucco F,Frühbeck G,Catalán V

更新日期：2017-06-01 00:00:00

abstract：PURPOSE OF THE REVIEW:In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative properties. RECENT FIN...

journal_title：Current diabetes reports

authors： Mantzouratou P,Lavecchia AM,Novelli R,Xinaris C

更新日期：2020-09-28 00:00:00

abstract：PURPOSE OF REVIEW:To highlight pathways important for the development of autoimmune diabetes by investigating shared mechanisms of disease in polygenic and monogenic diabetes. RECENT FINDINGS:Genome-wide association studies have identified 57 genetic risk loci for type 1 diabetes. Progress has been made in unravelling...

journal_title：Current diabetes reports

authors： Johnson MB,Cerosaletti K,Flanagan SE,Buckner JH

更新日期：2019-03-19 00:00:00

abstract：:Diabetic nephropathy is a clinical syndrome of albuminuria, declining glomerular filtration rate, and increased risk of cardiovascular disease. Multiple mechanisms have been implicated in its pathogenesis. Although current therapies appear to be effective, treatment of diabetic nephropathy remains suboptimal. This rev...

journal_title：Current diabetes reports

authors： Zhang Y,Guan Y

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:The measurement and estimation of diabetes in populations guides resource allocation, health priorities, and can influence practice and future research. To provide a critical reflection on current diabetes surveillance, we provide in-depth discussion about how upstream determinants, prevalence, incidence, and d...

journal_title：Current diabetes reports

authors： Ali MK,Siegel KR,Laxy M,Gregg EW

更新日期：2018-09-19 00:00:00

abstract：PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...

journal_title：Current diabetes reports

authors： Honasoge A,Nudleman E,Smith M,Rajagopal R

更新日期：2019-09-10 00:00:00

abstract：:Over the past 8 years, the genetics of complex traits have benefited from an unprecedented advancement in the identification of common variant loci for diseases such as type 2 diabetes (T2D). The ability to undertake genome-wide association studies in large population-based samples for quantitative glycaemic traits ha...

journal_title：Current diabetes reports

authors： Marullo L,El-Sayed Moustafa JS,Prokopenko I

更新日期：2014-01-01 00:00:00

abstract：:Goal setting is a widely used behavior change tool in diabetes education and training. Prior research found specific relatively difficult but attainable goals set within a specific timeframe improved performance in sports and at the workplace. However, the impact of goal setting in diabetes self-care has not received ...

journal_title：Current diabetes reports

authors： Miller CK,Bauman J

更新日期：2014-08-01 00:00:00

abstract：:About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and m...

journal_title：Current diabetes reports

authors： Seissler J

更新日期：2008-04-01 00:00:00

abstract：:The genomes of many species have now been completely sequenced including human and mouse. Great progress has been made in understanding the complex genetics that underlie diabetes and obesity in human populations. One of the current challenges is the functional identification and characterization of the genes within l...

journal_title：Current diabetes reports

authors： McMurray F,Moir L,Cox RD

更新日期：2012-12-01 00:00:00

abstract：PURPOSE OF REVIEW:A systematic review was conducted of family-based interventions to improve glycemic control, adherence, and psychosocial outcomes in children and adolescents with type 1 diabetes (T1D). Electronic databases were searched for randomized controlled trials (RCTs) published since the seminal Diabetes Cont...

journal_title：Current diabetes reports

authors： Feldman MA,Anderson LM,Shapiro JB,Jedraszko AM,Evans M,Weil LEG,Garza KP,Weissberg-Benchell J

更新日期：2018-02-19 00:00:00

abstract：PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...

journal_title：Current diabetes reports

authors： Khan MS,Vaduganathan M

更新日期：2020-10-11 00:00:00

abstract：:Impaired glucose tolerance (IGT) is characterized by plasma glucose responses to an oral glucose challenge that are above normal but not at the level defining diabetes. IGT is a common condition that greatly increases risk for the subsequent development of type 2 diabetes. Individuals with IGT manifest abnormalities i...

journal_title：Current diabetes reports

authors： Pratley RE,Weyer C

更新日期：2002-06-01 00:00:00

abstract：:Genes influence susceptibility to type 2 diabetes mellitus (T2DM), and both positional cloning and candidate gene approaches have been used to identify these genes. Linkage analysis has generated evidence for T2DM-predisposing variants on chromosome 20q in studies of Caucasians, Asians, and Africans, and fine-mapping ...

journal_title：Current diabetes reports

authors： Mohlke KL,Boehnke M

更新日期：2005-04-01 00:00:00

abstract：:Beta cell replacement therapy has been proposed as a novel therapy for the treatment of type 1 diabetes. The proof of concept has been demonstrated with successful islet allotransplantation. Islet xenotransplantation has been proposed as an alternative, more reliable, and infinite source of beta cells. The advantages ...

journal_title：Current diabetes reports

authors： O'Connell PJ,Cowan PJ,Hawthorne WJ,Yi S,Lew AM

更新日期：2013-10-01 00:00:00

abstract：:Although a clear relationship exists between glycosylated hemoglobin and cardiovascular (CV) disease in individuals with type 2 diabetes mellitus (T2DM) in epidemiologic studies, data from prospective studies are less clear. Earlier prospective studies examining intensive glucose lowering suffered from a lack of stati...

journal_title：Current diabetes reports

authors： Zarich SW

更新日期：2009-02-01 00:00:00

abstract：:In this review article, we first present a brief overview of the vascular and neural components of diabetic retinopathy. Next, the multifocal electroretinogram (mfERG) technique, which can map neuroretinal function noninvasively, is described. Findings in diabetic retinal disease using the mfERG are reviewed. We then ...

journal_title：Current diabetes reports

authors： Bearse MA Jr,Ozawa GY

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:Neuropathic pain may arise from multiple mechanisms and locations. Efficacy of current treatments for painful diabetic neuropathy is limited to an unpredictable subset of patients, possibly reflecting diversity of pain generator mechanisms, and there is a lack of targeted treatments for individual pat...

journal_title：Current diabetes reports

authors： Lee-Kubli C,Marshall AG,Malik RA,Calcutt NA

更新日期：2018-01-23 00:00:00

abstract：PURPOSE OF REVIEW:Obesity and diabetes are worldwide epidemics. There is also a growing body of evidence relating the gut microbiome composition to insulin resistance. The purpose of this review is to delineate the studies linking gut microbiota to obesity, metabolic syndrome, and diabetes. RECENT FINDINGS:Animal stud...

journal_title：Current diabetes reports

authors： Chen X,Devaraj S

更新日期：2018-10-18 00:00:00

abstract：:The endothelium has several diverse functions in maintaining vascular integrity in terms of structure and function. Two key vasodilators, nitric oxide (NO) and prostacyclin, maintain the vascular pathway, inhibit platelet aggregation, and are antithrombotic. More recently, they have been shown to be anti-inflammatory,...

journal_title：Current diabetes reports

authors： Dandona P

更新日期：2002-08-01 00:00:00

abstract：:Mobile and smartphone (mHealth) technologies have the potential to improve diabetes care and self-management, but little is known about their effectiveness and how patients, providers, and payers currently interact with them. We conducted a systematic review and found only 20 peer-reviewed articles, published since 20...

journal_title：Current diabetes reports

authors： Garabedian LF,Ross-Degnan D,Wharam JF

更新日期：2015-12-01 00:00:00

abstract：PURPOSE OF REVIEW:A growing body of epidemiological and experimental data indicate that nutritional or environmental stressors during early development can induce long-term adaptations that increase risk of obesity, diabetes, cardiovascular disease, and other chronic conditions-a phenomenon termed "developmental progra...

journal_title：Current diabetes reports

authors： Isganaitis E

更新日期：2019-07-20 00:00:00

abstract：:Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous system where mitochondrial dysfunction has been implicated as an etiological factor. Diabetes (type 1 or type 2) invokes an elevation of intracellular glucose concentration simultaneously with impaired growth factor support by insu...

journal_title：Current diabetes reports

authors： Fernyhough P

更新日期：2015-11-01 00:00:00

abstract：:Among the factors predisposing to type 2 diabetes in children, adolescents, and young adults, the health and behavior of both the mother and father are critical. Prevention and treatment of parental nutritional disorders (including obesity and malnutrition), promotion of breastfeeding, and avoidance of overfeeding of ...

journal_title：Current diabetes reports

authors： Bartz S,Freemark M

更新日期：2012-02-01 00:00:00

abstract：:Marijuana is used by millions of people, with use likely to increase in the USA because of the trend towards increased decriminalization and legalization. Obesity and diabetes mellitus (DM) rates have increased dramatically in the USA over the past 30 years, with a recent estimate of 29 million individuals with DM. Be...

journal_title：Current diabetes reports

authors： Sidney S

更新日期：2016-11-01 00:00:00

abstract：:The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related ...

journal_title：Current diabetes reports

authors： Giannini C,Caprio S

更新日期：2013-02-01 00:00:00