Abstract:
:Impaired glucose tolerance (IGT) is characterized by plasma glucose responses to an oral glucose challenge that are above normal but not at the level defining diabetes. IGT is a common condition that greatly increases risk for the subsequent development of type 2 diabetes. Individuals with IGT manifest abnormalities in both insulin action and early insulin secretion similar to those seen in patients with type 2 diabetes. These abnormalities not only precede diabetes, they predict it as well. Furthermore, the progression from IGT to diabetes is characterized by a dramatic decline in early insulin secretion. It is now evident that early insulin secretion plays an important role in the rapid and efficient suppression of endogenous glucose production following a meal. Loss of early insulin secretion initially leads to postprandial hyperglycemia which, as the disease progresses, worsens to clinical hyperglycemia. Obesity and a high fat diet may contribute to the development of both insulin resistance and insulin secretory dysfunction in susceptible individuals. Strategies that improve insulin resistance and enhance early insulin secretion may prevent the progression from IGT to diabetes. Already, there is substantial evidence the weight loss and exercise may reduce the risk of developing diabetes by up to 58%. Other trials using pharmacologic agents to decrease insulin resistance and increase early insulin secretion are underway. Prevention remains the best hope for a long-term solutions to the worldwide epidemic of diabetes.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Pratley RE,Weyer Cdoi
10.1007/s11892-002-0090-6keywords:
subject
Has Abstractpub_date
2002-06-01 00:00:00pages
242-8issue
3eissn
1534-4827issn
1539-0829journal_volume
2pub_type
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2014-04-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1218-2
更新日期:2019-09-10 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-019-1243-1
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journal_title:Current diabetes reports
pub_type: 杂志文章
doi:10.1007/s11892-006-0020-0
更新日期:2006-04-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01307-x
更新日期:2020-05-19 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0638-x
更新日期:2015-10-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2014-02-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2019-07-19 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2009-02-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-002-0069-3
更新日期:2002-04-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-003-0058-1
更新日期:2003-02-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-013-0377-9
更新日期:2013-06-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0294-3
更新日期:2012-10-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2011-10-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0627-0
更新日期:2015-08-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0796-5
更新日期:2016-11-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章
doi:10.1007/s11892-008-0069-z
更新日期:2008-10-01 00:00:00
abstract:PURPOSE OF REVIEW:Soon after the first genome-wide association study (GWAS) for type 2 diabetes (T2D) was published, it was hypothesized that rare and low-frequency variants might explain a substantial proportion of disease risk. Rare coding variants in particular were emphasized given their large expected role in dise...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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abstract:PURPOSE OF REVIEW:Type 2 diabetes is common, burdensome, and preventable. Landmark trials such as the Diabetes Prevention Program (DPP) demonstrated that resource-intensive lifestyle support interventions resulting in modest weight loss via healthy diet changes and physical activity can lower the rate of diabetes devel...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-1293-4
更新日期:2020-02-20 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0631-4
更新日期:2015-09-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01344-6
更新日期:2020-09-28 00:00:00
abstract:PURPOSE OF REVIEW:Diabetes is the leading cause of kidney disease globally. Diabetic kidney disease (DKD) is a heterogeneous disorder manifested as albuminuria and/or decreasing GFR. Hyperglycemic burden is the major contributor to the development of DKD. In this article, we review the evidence for the contribution of ...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-0979-3
更新日期:2018-02-15 00:00:00
abstract::The genomes of many species have now been completely sequenced including human and mouse. Great progress has been made in understanding the complex genetics that underlie diabetes and obesity in human populations. One of the current challenges is the functional identification and characterization of the genes within l...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0323-2
更新日期:2012-12-01 00:00:00
abstract::The common form of hereditary hemochromatosis is an autosomal recessive disorder most prevalent in Caucasians that results in excessive iron storage. The clinical manifestations of hemochromatosis are protean. HFE genotype, which determines the degree of iron overload and duration of disease have profound effects on d...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-014-0488-y
更新日期:2014-01-01 00:00:00
abstract:PURPOSE OF REVIEW:The Diabetes Prevention Program (DPP) is an evidence-based lifestyle change program for prediabetes that is associated with a 58% reduction in 3-year diabetes incidence, and it has been supported by the American Medical Association and the Centers for Disease Control and Prevention. However, 9 in 10 p...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1034-0
更新日期:2018-08-08 00:00:00
abstract:PURPOSE OF REVIEW:Evidence-based treatments for prediabetes can prevent and delay the development of type 2 diabetes in adults. In this review, we propose a framework for population-based diabetes prevention that links screening and prevention activities across key stakeholders. We also discuss gaps in current practice...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-018-1090-5
更新日期:2018-09-19 00:00:00
abstract::The coexistence of type 2 diabetes and obesity presents a complex therapeutic challenge. Future combination tablets may include agents to address diabetes and any accompanying cardiovascular risk factors. Injectable agents that improve glycemic control and facilitate weight loss have recently become available: the sol...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-005-0093-1
更新日期:2005-10-01 00:00:00
abstract::This review details the epidemiology, possible mechanisms, and risk factors associated with urogenital autonomic dysfunction in diabetes. Autonomic neuropathy in diabetes is associated with various urological complications including bladder and sexual dysfunction. Several studies have reported the high prevalence of b...
journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-016-0824-5
更新日期:2016-12-01 00:00:00