PPAR-gamma agonists and diabetic nephropathy.


:Diabetic nephropathy is a clinical syndrome of albuminuria, declining glomerular filtration rate, and increased risk of cardiovascular disease. Multiple mechanisms have been implicated in its pathogenesis. Although current therapies appear to be effective, treatment of diabetic nephropathy remains suboptimal. This review summarizes the recently emerging evidence suggesting that peroxisome proliferator-activated receptor-gamma agonists may prove to be effective therapeutic agents in the treatment of diabetic renal complications.


Curr Diab Rep


Current diabetes reports


Zhang Y,Guan Y





Has Abstract


2005-12-01 00:00:00












  • MicroRNAs in Diabetic Nephropathy: From Biomarkers to Therapy.

    abstract::Recent estimates suggest that 1 in 12 of the global population suffers from diabetes mellitus. Approximately 40 % of those affected will go on to develop diabetes-related chronic kidney disease or diabetic nephropathy (DN). DN is a major cause of disability and premature death. Existing tests for prognostic purposes a...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Simpson K,Wonnacott A,Fraser DJ,Bowen T

    更新日期:2016-03-01 00:00:00

  • Beyond HbA1c and glucose: the role of nontraditional glycemic markers in diabetes diagnosis, prognosis, and management.

    abstract::Fasting glucose and hemoglobin A1c (HbA1c) are the standard measures for diagnosis and monitoring of diabetes. There has been recent interest in nontraditional markers of hyperglycemia, including fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG), as alternatives or adjuncts to standard measures. There i...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Parrinello CM,Selvin E

    更新日期:2014-01-01 00:00:00

  • Genetic Mechanisms Highlight Shared Pathways for the Pathogenesis of Polygenic Type 1 Diabetes and Monogenic Autoimmune Diabetes.

    abstract:PURPOSE OF REVIEW:To highlight pathways important for the development of autoimmune diabetes by investigating shared mechanisms of disease in polygenic and monogenic diabetes. RECENT FINDINGS:Genome-wide association studies have identified 57 genetic risk loci for type 1 diabetes. Progress has been made in unravelling...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Johnson MB,Cerosaletti K,Flanagan SE,Buckner JH

    更新日期:2019-03-19 00:00:00

  • The Use of Non-insulin Agents in Gestational Diabetes: Clinical Considerations in Tailoring Therapy.

    abstract:PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Blair RA,Rosenberg EA,Palermo NE

    更新日期:2019-12-06 00:00:00

  • Nutrition and nonalcoholic fatty liver disease in children.

    abstract::Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease found in 3% to 9% of children in the United States. NAFLD represents a spectrum of liver disease and is frequently associated with features of the metabolic syndrome. Nutrition's role in NAFLD is complex. It does not appear that overweight...

    journal_title:Current diabetes reports

    pub_type: 杂志文章


    authors: Vos MB,McClain CJ

    更新日期:2008-10-01 00:00:00

  • Emerging Insights and Interventions for Diabetic Retinopathy.

    abstract:PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Honasoge A,Nudleman E,Smith M,Rajagopal R

    更新日期:2019-09-10 00:00:00

  • Diagnosis, screening, and management of cystic fibrosis-related diabetes.

    abstract::Diabetes is a common complication of cystic fibrosis (CF), occurring in approximately 40% of adult patients. It is clinically distinct from type 1 or type 2 diabetes, and requires a unique approach. Because of evidence that it is associated with increased morbidity and mortality, prompt diagnosis and aggressive manage...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Moran A

    更新日期:2002-04-01 00:00:00

  • Management of painful diabetic neuropathy: guideline guidance or jungle?

    abstract::The treatment of painful diabetic polyneuropathy (PDPN) remains a major challenge. A number of reasons have made the guidelines on PDPN management of particular interest, including its high prevalence, health and socioeconomic impact, interdisciplinary nature and the need for updated evidence-based information to refi...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Spallone V

    更新日期:2012-08-01 00:00:00

  • Diabetes and Disasters: Recent Studies and Resources for Preparedness.

    abstract:PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Allweiss P

    更新日期:2019-11-20 00:00:00

  • Euglycemic Ketoacidosis.

    abstract:PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyper...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Bonora BM,Avogaro A,Fadini GP

    更新日期:2020-05-19 00:00:00

  • National Strategies to Decrease the Burden of Diabetes and Its Complications.

    abstract::Comparative results from national strategies for diabetes care and prevention are needed to understand the impact and barriers encountered during the implementation process. Long-term outcomes are limited, but results on intermediate outcomes and processes of diabetes care measures are available from translational res...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Haw JS,Tantry S,Vellanki P,Pasquel FJ

    更新日期:2015-09-01 00:00:00

  • Recovery of endocrine function after islet and pancreas transplantation.

    abstract::Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Rickels MR

    更新日期:2012-10-01 00:00:00

  • Technological Advancements in the Management of Type 2 Diabetes.

    abstract:PURPOSE OF REVIEW:The increasing prevalence of type 2 diabetes is driving the boundaries of clinical diabetes care outside of the traditional office setting. The purpose of this paper will be to review recent technological advances in the medical management of people with type 2 diabetes, spanning the spectrum of care ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Grant AK,Golden L

    更新日期:2019-12-20 00:00:00

  • Lipodystrophic diabetes mellitus: a lesson for other forms of diabetes?

    abstract::Lipodystrophies are a genetically heterogeneous group of disorders characterized by loss of subcutaneous adipose tissue and metabolic dysfunction, including insulin resistance, increased levels of free fatty acids, abnormal adipocytokine secretion, and ectopic fat deposition, which are also observed in patients with v...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Ficarella R,Laviola L,Giorgino F

    更新日期:2015-03-01 00:00:00

  • What Makes Sodium-Glucose Co-Transporter-2 Inhibitors Stand out in Heart Failure?

    abstract:PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Khan MS,Vaduganathan M

    更新日期:2020-10-11 00:00:00

  • A review of adolescent adherence in type 1 diabetes and the untapped potential of diabetes providers to improve outcomes.

    abstract::Only 21 % of adolescents with type 1 diabetes (T1D) meet glycemic goals set forth by the American Diabetes Association. Adherence to therapy is a particular concern in this population, and the association between poor adherence and worsening glycemic control indicates that there is a critical need to improve adherence...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Datye KA,Moore DJ,Russell WE,Jaser SS

    更新日期:2015-08-01 00:00:00

  • The distinctive nature of atherosclerotic vascular disease in diabetes: pathophysiological and morphological insights.

    abstract::As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Puri R,Kataoka Y,Uno K,Nicholls SJ

    更新日期:2012-06-01 00:00:00

  • Pathophysiology of prediabetes.

    abstract::The term prediabetes refers to subjects with impaired fasting glucose and/or impaired glucose tolerance who are at increased risk for type 2 diabetes mellitus. Although both types of patients are at increased risk for developing type 2 diabetes mellitus and cardiovascular disease, they manifest distinct metabolic abno...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Abdul-Ghani MA,DeFronzo RA

    更新日期:2009-06-01 00:00:00

  • The Continuing Evolution of Precision Health in Type 2 Diabetes: Achievements and Challenges.

    abstract:PURPOSE OF REVIEW:The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. RECENT FINDINGS:Generation of multi-omic data to measure each of the "biologic layers," developments in describing genomic function an...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Lin Y,Wessel J

    更新日期:2019-02-26 00:00:00

  • Clues from bariatric surgery: reversing insulin resistance to heal the heart.

    abstract::Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectiv...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Khalaf KI,Taegtmeyer H

    更新日期:2013-04-01 00:00:00

  • Blood pressure control--effects on diabetic nephropathy progression: how low does blood pressure have to be?

    abstract::Hypertension and diabetes are independent risk factors for both cardiovascular disease and renal complications. Coexistence of these comorbid conditions predisposes the patient to a much greater risk of progression to end-stage renal disease. Combined with the increased cardiovascular mortality, this has led to recent...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Newton CA,Raskin P

    更新日期:2002-12-01 00:00:00

  • Psychosocial issues in youth with type 2 diabetes mellitus.

    abstract::Little published research exists on psychosocial issues in adolescents with type 2 diabetes mellitus (T2DM), because until two decades ago, diabetes diagnosed in children and adolescents was almost exclusively type 1 diabetes mellitus or insulin-dependent diabetes. In the past two decades, rates of T2DM have increased...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Anderson BJ,McKay SV

    更新日期:2009-04-01 00:00:00

  • Management of the insulin resistance syndrome.

    abstract::The insulin resistance syndrome (IRS) is a common disorder, which has important clinical implications. It is a cluster of cardiovascular risk factors that include obesity, hypertension, dyslipidemia, glucose intolerance, and type 2 diabetes mellitus. Lifestyle modifications and insulin sensitizers are among the severa...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Desouza C,Gilling L,Fonseca V

    更新日期:2001-10-01 00:00:00

  • Risks, benefits, and therapeutic potential of hematopoietic stem cell transplantation for autoimmune diabetes.

    abstract::Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing β cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory regimens were tested aiming at blocking some steps of the autoimmune process against β cell mass and ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Couri CE,de Oliveira MC,Simões BP

    更新日期:2012-10-01 00:00:00

  • Advancing Measurement of Diabetes at the Population Level.

    abstract:PURPOSE:The measurement and estimation of diabetes in populations guides resource allocation, health priorities, and can influence practice and future research. To provide a critical reflection on current diabetes surveillance, we provide in-depth discussion about how upstream determinants, prevalence, incidence, and d...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Ali MK,Siegel KR,Laxy M,Gregg EW

    更新日期:2018-09-19 00:00:00

  • Is the risk and nature of CVD the same in type 1 and type 2 diabetes?

    abstract::The incidence of both type 1 and type 2 diabetes is increasing globally, most likely explained by environmental changes, such as changing exposures to foods, viruses, and toxins, and by increasing obesity. While cardiovascular disease (CVD) mortality has been declining recently, this global epidemic of diabetes threat...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Duca L,Sippl R,Snell-Bergeon JK

    更新日期:2013-06-01 00:00:00

  • Fear of Hypoglycemia in Children and Adolescents and Their Parents with Type 1 Diabetes.

    abstract::Hypoglycemia is a frequent occurrence in children and adolescents with type 1 diabetes. A variety of efforts have been made to standardize the definition of hypoglycemia and to define one of its most significant psychosocial consequences-fear of hypoglycemia (FOH). In addition to documenting the experience of FOH in c...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Driscoll KA,Raymond J,Naranjo D,Patton SR

    更新日期:2016-08-01 00:00:00

  • Vascular and Endothelial Function in Youth with Type 2 Diabetes Mellitus.

    abstract:PURPOSE OF REVIEW:This review aims to discuss the burden of type 2 diabetes in youth and summarize the studies that have utilized noninvasive techniques to assess early vascular disease in youth with type 2 diabetes. RECENT FINDINGS:Noninvasive imaging modalities provide researchers with tools to investigate the vascu...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Shah AS,Urbina EM

    更新日期:2017-06-01 00:00:00

  • Is there a relationship between oral health and diabetic neuropathy?

    abstract::Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Borgnakke WS,Anderson PF,Shannon C,Jivanescu A

    更新日期:2015-11-01 00:00:00

  • Oral Agents for the Treatment of Gestational Diabetes.

    abstract:PURPOSE OF REVIEW:To review the current evidence of the safety and efficacy of the use of oral agents for treatment of gestational diabetes (GDM). RECENT FINDINGS:The use of metformin and glyburide in pregnancy for treatment of GDM has dramatically increased since the early 2000s. Meta-analyses suggest that glyburide ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审


    authors: Finneran MM,Landon MB

    更新日期:2018-09-28 00:00:00