PPAR-gamma agonists and diabetic nephropathy.

abstract：:Recent estimates suggest that 1 in 12 of the global population suffers from diabetes mellitus. Approximately 40 % of those affected will go on to develop diabetes-related chronic kidney disease or diabetic nephropathy (DN). DN is a major cause of disability and premature death. Existing tests for prognostic purposes a...

journal_title：Current diabetes reports

authors： Simpson K,Wonnacott A,Fraser DJ,Bowen T

更新日期：2016-03-01 00:00:00

abstract：:Fasting glucose and hemoglobin A1c (HbA1c) are the standard measures for diagnosis and monitoring of diabetes. There has been recent interest in nontraditional markers of hyperglycemia, including fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG), as alternatives or adjuncts to standard measures. There i...

journal_title：Current diabetes reports

authors： Parrinello CM,Selvin E

更新日期：2014-01-01 00:00:00

abstract：PURPOSE OF REVIEW:To highlight pathways important for the development of autoimmune diabetes by investigating shared mechanisms of disease in polygenic and monogenic diabetes. RECENT FINDINGS:Genome-wide association studies have identified 57 genetic risk loci for type 1 diabetes. Progress has been made in unravelling...

journal_title：Current diabetes reports

authors： Johnson MB,Cerosaletti K,Flanagan SE,Buckner JH

更新日期：2019-03-19 00:00:00

abstract：PURPOSE OF REVIEW:To assess evidence to date for use of non-insulin agents in treatment of gestational diabetes mellitus. RECENT FINDINGS:There has been increasing interest in the use of non-insulin agents, primarily metformin and glyburide (which both cross the placenta). Metformin has been associated with less mater...

journal_title：Current diabetes reports

authors： Blair RA,Rosenberg EA,Palermo NE

更新日期：2019-12-06 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease found in 3% to 9% of children in the United States. NAFLD represents a spectrum of liver disease and is frequently associated with features of the metabolic syndrome. Nutrition's role in NAFLD is complex. It does not appear that overweight...

journal_title：Current diabetes reports

authors： Vos MB,McClain CJ

更新日期：2008-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...

journal_title：Current diabetes reports

authors： Honasoge A,Nudleman E,Smith M,Rajagopal R

更新日期：2019-09-10 00:00:00

abstract：:Diabetes is a common complication of cystic fibrosis (CF), occurring in approximately 40% of adult patients. It is clinically distinct from type 1 or type 2 diabetes, and requires a unique approach. Because of evidence that it is associated with increased morbidity and mortality, prompt diagnosis and aggressive manage...

journal_title：Current diabetes reports

authors： Moran A

更新日期：2002-04-01 00:00:00

abstract：:The treatment of painful diabetic polyneuropathy (PDPN) remains a major challenge. A number of reasons have made the guidelines on PDPN management of particular interest, including its high prevalence, health and socioeconomic impact, interdisciplinary nature and the need for updated evidence-based information to refi...

journal_title：Current diabetes reports

authors： Spallone V

更新日期：2012-08-01 00:00:00

abstract：PURPOSE OF REVIEW:Studies have shown that disasters may exacerbate the comorbidities in vulnerable populations such as those with a pre-existing chronic medical condition like diabetes. This article highlights recent studies that look at the impact of disasters on people with diabetes and also shows recent resources fo...

journal_title：Current diabetes reports

authors： Allweiss P

更新日期：2019-11-20 00:00:00

abstract：PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyper...

journal_title：Current diabetes reports

authors： Bonora BM,Avogaro A,Fadini GP

更新日期：2020-05-19 00:00:00

abstract：:Comparative results from national strategies for diabetes care and prevention are needed to understand the impact and barriers encountered during the implementation process. Long-term outcomes are limited, but results on intermediate outcomes and processes of diabetes care measures are available from translational res...

journal_title：Current diabetes reports

authors： Haw JS,Tantry S,Vellanki P,Pasquel FJ

更新日期：2015-09-01 00:00:00

abstract：:Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...

journal_title：Current diabetes reports

authors： Rickels MR

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:The increasing prevalence of type 2 diabetes is driving the boundaries of clinical diabetes care outside of the traditional office setting. The purpose of this paper will be to review recent technological advances in the medical management of people with type 2 diabetes, spanning the spectrum of care ...

journal_title：Current diabetes reports

authors： Grant AK,Golden L

更新日期：2019-12-20 00:00:00

abstract：:Lipodystrophies are a genetically heterogeneous group of disorders characterized by loss of subcutaneous adipose tissue and metabolic dysfunction, including insulin resistance, increased levels of free fatty acids, abnormal adipocytokine secretion, and ectopic fat deposition, which are also observed in patients with v...

journal_title：Current diabetes reports

authors： Ficarella R,Laviola L,Giorgino F

更新日期：2015-03-01 00:00:00

abstract：PURPOSE OF REVIEW:We highlight the unique properties of the sodium-glucose cotransporter-2 (SGLT-2 inhibitors) which may lend favorably to their efficient integration in the background of other heart failure (HF) therapies. We also discuss the unique aspects of SGLT-2 inhibitor dosing, lack of titration needs, effects ...

journal_title：Current diabetes reports

authors： Khan MS,Vaduganathan M

更新日期：2020-10-11 00:00:00

abstract：:Only 21 % of adolescents with type 1 diabetes (T1D) meet glycemic goals set forth by the American Diabetes Association. Adherence to therapy is a particular concern in this population, and the association between poor adherence and worsening glycemic control indicates that there is a critical need to improve adherence...

journal_title：Current diabetes reports

authors： Datye KA,Moore DJ,Russell WE,Jaser SS

更新日期：2015-08-01 00:00:00

abstract：:As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...

journal_title：Current diabetes reports

authors： Puri R,Kataoka Y,Uno K,Nicholls SJ

更新日期：2012-06-01 00:00:00

abstract：:The term prediabetes refers to subjects with impaired fasting glucose and/or impaired glucose tolerance who are at increased risk for type 2 diabetes mellitus. Although both types of patients are at increased risk for developing type 2 diabetes mellitus and cardiovascular disease, they manifest distinct metabolic abno...

journal_title：Current diabetes reports

authors： Abdul-Ghani MA,DeFronzo RA

更新日期：2009-06-01 00:00:00

abstract：PURPOSE OF REVIEW:The purpose of this review was to summarize recent advances in the genomics of type 2 diabetes (T2D) and to highlight current initiatives to advance precision health. RECENT FINDINGS:Generation of multi-omic data to measure each of the "biologic layers," developments in describing genomic function an...

journal_title：Current diabetes reports

authors： Lin Y,Wessel J

更新日期：2019-02-26 00:00:00

abstract：:Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectiv...

journal_title：Current diabetes reports

authors： Khalaf KI,Taegtmeyer H

更新日期：2013-04-01 00:00:00

abstract：:Hypertension and diabetes are independent risk factors for both cardiovascular disease and renal complications. Coexistence of these comorbid conditions predisposes the patient to a much greater risk of progression to end-stage renal disease. Combined with the increased cardiovascular mortality, this has led to recent...

journal_title：Current diabetes reports

authors： Newton CA,Raskin P

更新日期：2002-12-01 00:00:00

abstract：:Little published research exists on psychosocial issues in adolescents with type 2 diabetes mellitus (T2DM), because until two decades ago, diabetes diagnosed in children and adolescents was almost exclusively type 1 diabetes mellitus or insulin-dependent diabetes. In the past two decades, rates of T2DM have increased...

journal_title：Current diabetes reports

authors： Anderson BJ,McKay SV

更新日期：2009-04-01 00:00:00

abstract：:The insulin resistance syndrome (IRS) is a common disorder, which has important clinical implications. It is a cluster of cardiovascular risk factors that include obesity, hypertension, dyslipidemia, glucose intolerance, and type 2 diabetes mellitus. Lifestyle modifications and insulin sensitizers are among the severa...

journal_title：Current diabetes reports

authors： Desouza C,Gilling L,Fonseca V

更新日期：2001-10-01 00:00:00

abstract：:Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing β cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory regimens were tested aiming at blocking some steps of the autoimmune process against β cell mass and ...

journal_title：Current diabetes reports

authors： Couri CE,de Oliveira MC,Simões BP

更新日期：2012-10-01 00:00:00

abstract：PURPOSE:The measurement and estimation of diabetes in populations guides resource allocation, health priorities, and can influence practice and future research. To provide a critical reflection on current diabetes surveillance, we provide in-depth discussion about how upstream determinants, prevalence, incidence, and d...

journal_title：Current diabetes reports

authors： Ali MK,Siegel KR,Laxy M,Gregg EW

更新日期：2018-09-19 00:00:00

abstract：:The incidence of both type 1 and type 2 diabetes is increasing globally, most likely explained by environmental changes, such as changing exposures to foods, viruses, and toxins, and by increasing obesity. While cardiovascular disease (CVD) mortality has been declining recently, this global epidemic of diabetes threat...

journal_title：Current diabetes reports

authors： Duca L,Sippl R,Snell-Bergeon JK

更新日期：2013-06-01 00:00:00

abstract：:Hypoglycemia is a frequent occurrence in children and adolescents with type 1 diabetes. A variety of efforts have been made to standardize the definition of hypoglycemia and to define one of its most significant psychosocial consequences-fear of hypoglycemia (FOH). In addition to documenting the experience of FOH in c...

journal_title：Current diabetes reports

authors： Driscoll KA,Raymond J,Naranjo D,Patton SR

更新日期：2016-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This review aims to discuss the burden of type 2 diabetes in youth and summarize the studies that have utilized noninvasive techniques to assess early vascular disease in youth with type 2 diabetes. RECENT FINDINGS:Noninvasive imaging modalities provide researchers with tools to investigate the vascu...

journal_title：Current diabetes reports

authors： Shah AS,Urbina EM

更新日期：2017-06-01 00:00:00

abstract：:Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...

journal_title：Current diabetes reports

authors： Borgnakke WS,Anderson PF,Shannon C,Jivanescu A

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current evidence of the safety and efficacy of the use of oral agents for treatment of gestational diabetes (GDM). RECENT FINDINGS:The use of metformin and glyburide in pregnancy for treatment of GDM has dramatically increased since the early 2000s. Meta-analyses suggest that glyburide ...

journal_title：Current diabetes reports

authors： Finneran MM,Landon MB

更新日期：2018-09-28 00:00:00