PPAR-gamma agonists and diabetic nephropathy.

abstract：:Diabetic nephropathy has become the main cause of renal failure, but unfortunately the intimate mechanisms leading to the development and progression of renal injury are not yet fully known. Activated innate immunity and inflammation are relevant factors in the pathogenesis of diabetes. Moreover, different inflammator...

journal_title：Current diabetes reports

authors： Mora C,Navarro JF

更新日期：2006-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To provide an update of glycemic management during metabolic stress related to surgery or critical illness. RECENT FINDINGS:There is a clear association between severe hyperglycemia, hypoglycemia, and high glycemic variability and poor outcomes of postoperative or critically ill patients. However, th...

journal_title：Current diabetes reports

authors： Mongkolpun W,Provenzano B,Preiser JC

更新日期：2019-11-20 00:00:00

abstract：:Complementary and alternative medicine (CAM) describes a diverse group of medical and health care systems, practices, and products not currently considered to be part of conventional medicine. Inadequacies in current treatments for diabetes have led 2 to 3.6 million Americans to use CAM for diabetes treatment, despite...

journal_title：Current diabetes reports

authors： Dham S,Shah V,Hirsch S,Banerji MA

更新日期：2006-06-01 00:00:00

abstract：:Maintaining normal blood glucose levels is a constant challenge for women with diabetes. Anecdotal reports reveal that many women question if menstrual cycle phases may affect their blood glucose levels. However, results from studies investigating the effect of the menstrual cycle on insulin sensitivity in diabetic wo...

journal_title：Current diabetes reports

authors： Trout KK,Teff KL

更新日期：2004-08-01 00:00:00

abstract：:Diabetes self-management education (DSME) has been shown to improve health outcomes. Yet, relatively little is known about how DSME has its effects. Literature reviewed from the past 3 years indicates that if DSME is to become more effective interventions need to be theory-based, to increase patient involvement in the...

journal_title：Current diabetes reports

authors： Williams GC,Zeldman A

更新日期：2002-04-01 00:00:00

abstract：PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell bi...

journal_title：Current diabetes reports

authors： Kim J,Kang K,Drogemuller CJ,Wallace GG,Coates PT

更新日期：2019-07-04 00:00:00

abstract：PURPOSES OF REVIEW:Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve t...

journal_title：Current diabetes reports

authors： Smink AM,de Vos P

更新日期：2018-05-19 00:00:00

abstract：:Type 1 and type 2 diabetes both accelerate cardiovascular disease, yet the triggers are likely different for the two types of diabetes. Results from large-scale clinical trials suggest that intense blood glucose control can reduce cardiovascular events many years later in patients with type 1 diabetes. In type 2 diabe...

journal_title：Current diabetes reports

authors： Averill MM,Bornfeldt KE

更新日期：2009-02-01 00:00:00

abstract：:The therapy of type 1 diabetes is an open challenging problem. The restoration of normoglycemia and insulin independence in immunosuppressed type 1 diabetic recipients of islet allotransplantation has shown the potential of a cell-based diabetes therapy. Even if successful, this approach poses a problem of scarce tiss...

journal_title：Current diabetes reports

authors： Marigliano M,Bertera S,Grupillo M,Trucco M,Bottino R

更新日期：2011-10-01 00:00:00

abstract：:Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presenta...

journal_title：Current diabetes reports

authors： Lauria G,Ziegler D,Malik R,Merkies IS,Waxman SG,Faber CG,PROPANE Study group.

更新日期：2014-10-01 00:00:00

abstract：PURPOSE OF REVIEW:To review the current evidence of the safety and efficacy of the use of oral agents for treatment of gestational diabetes (GDM). RECENT FINDINGS:The use of metformin and glyburide in pregnancy for treatment of GDM has dramatically increased since the early 2000s. Meta-analyses suggest that glyburide ...

journal_title：Current diabetes reports

authors： Finneran MM,Landon MB

更新日期：2018-09-28 00:00:00

abstract：PURPOSE OF REVIEW:The Diabetes Prevention Program (DPP) is an evidence-based lifestyle change program for prediabetes that is associated with a 58% reduction in 3-year diabetes incidence, and it has been supported by the American Medical Association and the Centers for Disease Control and Prevention. However, 9 in 10 p...

journal_title：Current diabetes reports

authors： Jasik CB,Joy E,Brunisholz KD,Kirley K

更新日期：2018-08-08 00:00:00

abstract：:The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gene are associated no...

journal_title：Current diabetes reports

authors： Zhao X,Yang Y,Sun BF,Zhao YL,Yang YG

更新日期：2014-01-01 00:00:00

abstract：:Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated liver disease found in 3% to 9% of children in the United States. NAFLD represents a spectrum of liver disease and is frequently associated with features of the metabolic syndrome. Nutrition's role in NAFLD is complex. It does not appear that overweight...

journal_title：Current diabetes reports

authors： Vos MB,McClain CJ

更新日期：2008-10-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early ...

journal_title：Current diabetes reports

authors： Endesfelder D,Engel M,Zu Castell W

更新日期：2016-07-01 00:00:00

abstract：:About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and m...

journal_title：Current diabetes reports

authors： Seissler J

更新日期：2008-04-01 00:00:00

abstract：PURPOSE OF REVIEW:To evaluate the treatment of type 2 diabetes from a cardiologist's view. RECENT FINDINGS:A new era in the treatment of type 2 diabetes began for the cardiologist in 2015 with the publication of the EMPA-REG outcome trial finding a significant reduction in CV death with empagliflozin (oral sodium-gluc...

journal_title：Current diabetes reports

authors： Chilton RJ,Gallegos KM,Silva-Cardoso J,Oliveros R,Pham S

更新日期：2018-11-08 00:00:00

abstract：PURPOSE OF REVIEW:Obesity in the older adult is a burgeoning health epidemic that leads to increased morbidity, disability, and institutionalization. This review presents a brief overview of geriatric-specific consequences of obesity by highlighting the risks and benefits of intentional weight loss. RECENT FINDINGS:In...

journal_title：Current diabetes reports

authors： DiMilia PR,Mittman AC,Batsis JA

更新日期：2019-11-04 00:00:00

abstract：:Hypoglycemia is a common problem in hospitalized patients, particularly the elderly, frail, and severely ill. Hypoglycemia has been implicated in the development of adverse clinical outcomes, including increased mortality. Fear of iatrogenic hypoglycemia remains an obstacle to adequate inpatient glycemic control. Howe...

journal_title：Current diabetes reports

authors： Carey M,Boucai L,Zonszein J

更新日期：2013-02-01 00:00:00

abstract：:Diabetic patients are at increased risk for developing cardiovascular disease, and they constitute a large proportion of the global cardiovascular disease burden. Although multiple drugs exist for treating the hyperglycemia associated with diabetes, few have been shown to reduce cardiovascular risk. Great hope surroun...

journal_title：Current diabetes reports

authors： Lieb DC,McCall AL

更新日期：2010-04-01 00:00:00

abstract：:Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...

journal_title：Current diabetes reports

authors： Rickels MR

更新日期：2012-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Diabetes is the leading cause of kidney disease globally. Diabetic kidney disease (DKD) is a heterogeneous disorder manifested as albuminuria and/or decreasing GFR. Hyperglycemic burden is the major contributor to the development of DKD. In this article, we review the evidence for the contribution of ...

journal_title：Current diabetes reports

authors： Subramanian S,Hirsch IB

更新日期：2018-02-15 00:00:00

abstract：PURPOSE OF REVIEW:Diabetic kidney disease (DKD) is the leading cause of kidney failure in the USA, representing ~ 44% of all cases of kidney failure. Advancements in both glucose management and inhibitors of the renin-angiotensin system have significantly improved prognosis for individuals with DKD, yet DKD continues t...

journal_title：Current diabetes reports

authors： Wiley CD

更新日期：2020-06-16 00:00:00

abstract：:Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...

journal_title：Current diabetes reports

authors： Durnwald CP,Landon MB

更新日期：2011-02-01 00:00:00

abstract：:The treatment of painful diabetic polyneuropathy (PDPN) remains a major challenge. A number of reasons have made the guidelines on PDPN management of particular interest, including its high prevalence, health and socioeconomic impact, interdisciplinary nature and the need for updated evidence-based information to refi...

journal_title：Current diabetes reports

authors： Spallone V

更新日期：2012-08-01 00:00:00

abstract：:The coexistence of type 2 diabetes and obesity presents a complex therapeutic challenge. Future combination tablets may include agents to address diabetes and any accompanying cardiovascular risk factors. Injectable agents that improve glycemic control and facilitate weight loss have recently become available: the sol...

journal_title：Current diabetes reports

authors： Bailey CJ

更新日期：2005-10-01 00:00:00

abstract：:There is a well-documented gap between research and practice in diabetes and many other chronic illnesses. This gap is due, in part, to limitations of the research database. Different types of clinical trials have recently been called for that address issues central to clinicians, administrative decision makers, and p...

journal_title：Current diabetes reports

authors： Glasgow RE

更新日期：2004-04-01 00:00:00

abstract：:Continuous glucose monitoring (CGM) is an emerging technology that provides a continuous measure of interstitial glucose levels. In addition to providing a more complete pattern of glucose excursions, CGMs utilize real-time alarms for thresholds and predictions of hypo- and hyperglycemia, as well as rate of change ala...

journal_title：Current diabetes reports

authors： DeSalvo D,Buckingham B

更新日期：2013-10-01 00:00:00

abstract：:This article reviews selected recent literature on adult diabetes patient-centered adherence to diabetes care recommendations. We describe more fully a limited number of articles that have particular lessons for diabetes clinicians and researchers. Each article was reviewed for methodology, adherence measures, and typ...

journal_title：Current diabetes reports

authors： Walker EA,Usher JA

更新日期：2003-04-01 00:00:00

abstract：:Recent estimates suggest that 1 in 12 of the global population suffers from diabetes mellitus. Approximately 40 % of those affected will go on to develop diabetes-related chronic kidney disease or diabetic nephropathy (DN). DN is a major cause of disability and premature death. Existing tests for prognostic purposes a...

journal_title：Current diabetes reports

authors： Simpson K,Wonnacott A,Fraser DJ,Bowen T

更新日期：2016-03-01 00:00:00