Abstract:
:Unfortunately, the only approved medical treatment for type 1 diabetes mellitus (DM) is insulin, despite the fact that tight control cannot be reached without some serious side effects such as hypoglycemia and weight gain. More and more importance is now shifted towards developing new drugs that can reach a better glycemic control with lesser side effects. Some of these promising drugs are the glucagon-like peptides 1 (GLP-1) and their agonists, which have been FDA approved for the treatment of type 2 DM. The purpose of this article is to review all of the relevant literature on the potential role of GLP-1 in the treatment of type 1 DM. The major source of data acquisition included Medline search strategies, using the words "type 1 diabetes mellitus" and "GLP-1." Articles published in the last 20 years were screened. GLP-1 increases insulin secretion in humans with existing beta cells; it also decreases glucagon secretion, and blunts appetite. Of note, new animal studies demonstrate a role in beta cell-proliferation and decreased apoptosis. Because of all the effects mentioned above, GLP-1 seems to be a promising drug for type 1 DM treatment, but more studies are still needed before solid conclusions can be drawn.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Issa CM,Azar STdoi
10.1007/s11892-012-0291-6subject
Has Abstractpub_date
2012-10-01 00:00:00pages
560-7issue
5eissn
1534-4827issn
1539-0829journal_volume
12pub_type
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pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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更新日期:2018-03-21 00:00:00
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