Are the ADA hemoglobin A(1c) criteria relevant for the diagnosis of type 2 diabetes in youth?

Abstract:

:Diagnostic criteria for diabetes in children have not been established with nearly the rigor as that employed in adults. Recently revised American Diabetes Association (ADA) criteria allowed utilization of hemoglobin A(1c) (HbA1c) ≥ 6.5 % for diagnosis of diabetes. A recent series of pediatric studies appear to show that HbA1c has lower sensitivity than Fasting plasma glucose (FPG) or oral glucose tolerance test (OGTT). However, FPG and OGTT have themselves never been validated in children. Studies to validate diagnostic thresholds in children appear unlikely to take place. Thus, accepting the major ADA diagnostic criteria appears to be the best course of action for the pediatric community. One area in which correlation studies between HbA1c and FPG or OGTT might shed light is in the definition of criteria for intervention in 'pre-diabetes,' as the Diabetes Prevention Program Trial did not use HbA1c. However, such treatment, and the exact diagnostic thresholds at which it should be initiated in children, remains unproven.

journal_name

Curr Diab Rep

journal_title

Current diabetes reports

authors

Kapadia CR

doi

10.1007/s11892-012-0343-y

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

51-5

issue

1

eissn

1534-4827

issn

1539-0829

journal_volume

13

pub_type

杂志文章,评审
  • Goal setting: an integral component of effective diabetes care.

    abstract::Goal setting is a widely used behavior change tool in diabetes education and training. Prior research found specific relatively difficult but attainable goals set within a specific timeframe improved performance in sports and at the workplace. However, the impact of goal setting in diabetes self-care has not received ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-014-0509-x

    authors: Miller CK,Bauman J

    更新日期:2014-08-01 00:00:00

  • Novel targets against retinal angiogenesis in diabetic retinopathy.

    abstract::Proliferative diabetic retinopathy (PDR), characterized by pathologic retinal angiogenesis, is a major cause of blindness in the USA and globally. Treatments targeting vascular endothelial growth factor (VEGF) have emerged as a beneficial part of the therapeutic armamentarium for this condition, highlighting the utili...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-012-0289-0

    authors: Wang S,Park JK,Duh EJ

    更新日期:2012-08-01 00:00:00

  • Bariatric Surgery for Monogenic Non-syndromic and Syndromic Obesity Disorders.

    abstract:PURPOSE OF REVIEW:The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown whether this treatment is also suitable for patients with obesity due to a co...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01327-7

    authors: Vos N,Oussaada SM,Cooiman MI,Kleinendorst L,Ter Horst KW,Hazebroek EJ,Romijn JA,Serlie MJ,Mannens MMAM,van Haelst MM

    更新日期:2020-07-30 00:00:00

  • Nutrition therapy for dyslipidemia.

    abstract::National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-003-0084-z

    authors: Carson JA

    更新日期:2003-10-01 00:00:00

  • Association of albuminuria and the metabolic syndrome.

    abstract::Microalbuminuria clusters with the metabolic syndrome, and both conditions predict cardiovascular disease mortality. The reported relationships of microalbuminuria with the individual components of the metabolic syndrome (i.e., hyperglycemia, insulin resistance, hypertension, dyslipidemia, abdominal obesity) are varia...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-003-0058-1

    authors: Rowley K,O'Dea K,Best JD

    更新日期:2003-02-01 00:00:00

  • The Contribution of Low-Frequency and Rare Coding Variation to Susceptibility to Type 2 Diabetes.

    abstract:PURPOSE OF REVIEW:Soon after the first genome-wide association study (GWAS) for type 2 diabetes (T2D) was published, it was hypothesized that rare and low-frequency variants might explain a substantial proportion of disease risk. Rare coding variants in particular were emphasized given their large expected role in dise...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1142-5

    authors: Flannick J

    更新日期:2019-04-08 00:00:00

  • Caveolin-1 in the Pathogenesis of Diabetic Nephropathy: Potential Therapeutic Target?

    abstract:PURPOSE OF REVIEW:Diabetic nephropathy, a major microvascular complication of diabetes and the most common cause of end-stage renal disease, is characterized by prominent accumulation of extracellular matrix. The membrane microdomains caveolae, and their integral protein caveolin-1, play critical roles in the regulatio...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-017-0844-9

    authors: Van Krieken R,Krepinsky JC

    更新日期:2017-03-01 00:00:00

  • Newer agents for the treatment of painful diabetic peripheral neuropathy.

    abstract::Neuropathic pain is responsible for a significant amount of the morbidity associated with generalized and focal peripheral neuropathies in diabetes. It is a consequence of alterations in neuronal function, chemistry, and structure that occur secondary to nerve injury. A variety of agents from diverse pharmacologic cla...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-005-0047-7

    authors: Freeman R

    更新日期:2005-12-01 00:00:00

  • Euglycemic Ketoacidosis.

    abstract:PURPOSE OF REVIEW:Diabetic ketoacidosis is a life-threatening complication of diabetes characterized by hyperglycemia, acidosis, and ketosis. Ketoacidosis may occur with blood glucose level < 200 mg/dl (improperly defined as euglycemic ketoacidosis, euKA) and also in people without diabetes. The absence of marked hyper...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01307-x

    authors: Bonora BM,Avogaro A,Fadini GP

    更新日期:2020-05-19 00:00:00

  • Fear of Hypoglycemia in Children and Adolescents and Their Parents with Type 1 Diabetes.

    abstract::Hypoglycemia is a frequent occurrence in children and adolescents with type 1 diabetes. A variety of efforts have been made to standardize the definition of hypoglycemia and to define one of its most significant psychosocial consequences-fear of hypoglycemia (FOH). In addition to documenting the experience of FOH in c...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0762-2

    authors: Driscoll KA,Raymond J,Naranjo D,Patton SR

    更新日期:2016-08-01 00:00:00

  • Risks, benefits, and therapeutic potential of hematopoietic stem cell transplantation for autoimmune diabetes.

    abstract::Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing β cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory regimens were tested aiming at blocking some steps of the autoimmune process against β cell mass and ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-012-0309-0

    authors: Couri CE,de Oliveira MC,Simões BP

    更新日期:2012-10-01 00:00:00

  • The Genetic Contribution to Type 1 Diabetes.

    abstract:PURPOSE OF REVIEW:To provide an updated summary of discoveries made to date resulting from genome-wide association study (GWAS) and sequencing studies, and to discuss the latest loci added to the growing repertoire of genetic signals predisposing to type 1 diabetes (T1D). RECENT FINDINGS:Genetic studies have identifie...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1235-1

    authors: Bakay M,Pandey R,Grant SFA,Hakonarson H

    更新日期:2019-11-04 00:00:00

  • New treatments for diabetic neuropathy: pathogenetically oriented treatment.

    abstract::Although there is clear evidence from experimental diabetic neuropathy (DN) models that the multiple pathways involved in neuronal degeneration cause overproduction of reactive oxygen species, oxidative stress, and cellular dysfunction, therapeutic approaches addressing these mechanisms have not yet provided a basis f...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-003-0007-z

    authors: Bierhaus A,Humpert PM,Rudofsky G,Wendt T,Morcos M,Hamann A,Nawroth PP

    更新日期:2003-12-01 00:00:00

  • Drugs on the horizon for diabesity.

    abstract::The coexistence of type 2 diabetes and obesity presents a complex therapeutic challenge. Future combination tablets may include agents to address diabetes and any accompanying cardiovascular risk factors. Injectable agents that improve glycemic control and facilitate weight loss have recently become available: the sol...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-005-0093-1

    authors: Bailey CJ

    更新日期:2005-10-01 00:00:00

  • Endothelial dysfunction in human diabetes.

    abstract::In nondiabetic individuals, a poor response to an endothelium-dependent vasodilator in coronary vessels has been shown to increase the likelihood of a future cardiovascular event. Such prospective data are not as yet available in patients with type 1 or type 2 diabetes. However, consistent with the greatly increased c...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-002-0054-x

    authors: Mäkimattila S,Yki-Järvinen H

    更新日期:2002-02-01 00:00:00

  • Simultaneous Pancreas and Kidney Transplantation-Is It a Treatment Option for Patients With Type 2 Diabetes Mellitus? An Analysis of the International Pancreas Transplant Registry.

    abstract:PURPOSE OF REVIEW:Pancreas transplantation remains the best long-term treatment option to achieve euglycemia and freedom from insulin in patients with labile diabetes mellitus. It is an approved procedure for type 1 (T1DM), but it is still considered controversial for type 2 diabetes mellitus (T2DM). RECENT FINDINGS:T...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-017-0864-5

    authors: Gruessner AC,Laftavi MR,Pankewycz O,Gruessner RWG

    更新日期:2017-06-01 00:00:00

  • Pathophysiology of prediabetes.

    abstract::The term prediabetes refers to subjects with impaired fasting glucose and/or impaired glucose tolerance who are at increased risk for type 2 diabetes mellitus. Although both types of patients are at increased risk for developing type 2 diabetes mellitus and cardiovascular disease, they manifest distinct metabolic abno...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-009-0032-7

    authors: Abdul-Ghani MA,DeFronzo RA

    更新日期:2009-06-01 00:00:00

  • Is there a relationship between oral health and diabetic neuropathy?

    abstract::Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0673-7

    authors: Borgnakke WS,Anderson PF,Shannon C,Jivanescu A

    更新日期:2015-11-01 00:00:00

  • The role of complementary and alternative medicine in diabetes.

    abstract::Complementary and alternative medicine (CAM) describes a diverse group of medical and health care systems, practices, and products not currently considered to be part of conventional medicine. Inadequacies in current treatments for diabetes have led 2 to 3.6 million Americans to use CAM for diabetes treatment, despite...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-006-0042-7

    authors: Dham S,Shah V,Hirsch S,Banerji MA

    更新日期:2006-06-01 00:00:00

  • Glucagon and type 2 diabetes: the return of the alpha cell.

    abstract::In normal physiology, glucagon from pancreatic alpha cells plays an important role in maintaining glucose homeostasis via its regulatory effect on hepatic glucose production. Patients with type 2 diabetes suffer from fasting and postprandial hyperglucagonemia, which stimulate hepatic glucose production and, thus, cont...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-014-0555-4

    authors: Lund A,Bagger JI,Christensen M,Knop FK,Vilsbøll T

    更新日期:2014-12-01 00:00:00

  • Diabetes and Cognitive Impairment.

    abstract::Both type 1 (T1DM) and type 2 diabetes mellitus (T2DM) have been associated with reduced performance on multiple domains of cognitive function and with evidence of abnormal structural and functional brain magnetic resonance imaging (MRI). Cognitive deficits may occur at the very earliest stages of diabetes and are fur...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0775-x

    authors: Zilliox LA,Chadrasekaran K,Kwan JY,Russell JW

    更新日期:2016-09-01 00:00:00

  • The use of bolus insulin and advancing insulin therapy in type 2 diabetes.

    abstract::Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-004-0037-1

    authors: Karl DM

    更新日期:2004-10-01 00:00:00

  • Bioprinting an Artificial Pancreas for Type 1 Diabetes.

    abstract:PURPOSE OF REVIEW:Pancreatic islet cell transplantation is currently the only curative cell therapy for type 1 diabetes mellitus. However, its potential to treat many more patients is limited by several challenges. The emergence of 3D bioprinting technology from recent advances in 3D printing, biomaterials, and cell bi...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1166-x

    authors: Kim J,Kang K,Drogemuller CJ,Wallace GG,Coates PT

    更新日期:2019-07-04 00:00:00

  • Medical Devices in Obesity Treatment.

    abstract:PURPOSE OF REVIEW:Obesity is increasing at an alarming rate and now poses a global threat to humankind. In recent years, we have seen the emergence of medical devices to combat the obesity epidemic. These therapeutic strategies are discussed in this review dividing them into gastric and duodenal therapies. RECENT FIND...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1217-3

    authors: Ruban A,Doshi A,Lam E,Teare JP

    更新日期:2019-08-30 00:00:00

  • Self- and Social-Regulation in Type 1 Diabetes Management During Late Adolescence and Emerging Adulthood.

    abstract:PURPOSE OF REVIEW:This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS:Problems in cognitive...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-018-0995-3

    authors: Wiebe DJ,Berg CA,Mello D,Kelly CS

    更新日期:2018-03-21 00:00:00

  • The Charcot foot: medical and surgical therapy.

    abstract::Charcot neuro-osteoarthropathy (CN) is among the most devastating complications of neuropathy and now most commonly occurs in the feet of diabetic patients. Because it is relatively rare and because most patients and practitioners do not expect major bone pathology in the absence of significant pain, CN is often misdi...

    journal_title:Current diabetes reports

    pub_type: 杂志文章

    doi:10.1007/s11892-008-0077-z

    authors: Ulbrecht JS,Wukich DK

    更新日期:2008-12-01 00:00:00

  • Thyroid Hormone Signalling Alteration in Diabetic Nephropathy and Cardiomyopathy: a "Switch" to the Foetal Gene Programme.

    abstract:PURPOSE OF THE REVIEW:In this study, we will analyse how diabetes induces the reactivation of organs' developmental programmes and growth, discuss how thyroid hormone (TH) signalling orchestrates these processes, and suggest novel strategies for exploiting TH-mediated reparative and regenerative properties. RECENT FIN...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-020-01344-6

    authors: Mantzouratou P,Lavecchia AM,Novelli R,Xinaris C

    更新日期:2020-09-28 00:00:00

  • Technological Advancements in the Management of Type 2 Diabetes.

    abstract:PURPOSE OF REVIEW:The increasing prevalence of type 2 diabetes is driving the boundaries of clinical diabetes care outside of the traditional office setting. The purpose of this paper will be to review recent technological advances in the medical management of people with type 2 diabetes, spanning the spectrum of care ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-019-1278-3

    authors: Grant AK,Golden L

    更新日期:2019-12-20 00:00:00

  • Self-Care Disparities Among Adults with Type 2 Diabetes in the USA.

    abstract::Suboptimal glycemic control is more common among non-Hispanic Blacks (NHBs) and Hispanics than non-Hispanic Whites (NHWs). Disparities in the performance of self-care behaviors may contribute to this. To synthesize knowledge on current self-care disparities, we reviewed studies from January 2011-March 2016 that includ...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-016-0796-5

    authors: Mayberry LS,Bergner EM,Chakkalakal RJ,Elasy TA,Osborn CY

    更新日期:2016-11-01 00:00:00

  • Mitochondrial dysfunction in diabetic neuropathy: a series of unfortunate metabolic events.

    abstract::Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous system where mitochondrial dysfunction has been implicated as an etiological factor. Diabetes (type 1 or type 2) invokes an elevation of intracellular glucose concentration simultaneously with impaired growth factor support by insu...

    journal_title:Current diabetes reports

    pub_type: 杂志文章,评审

    doi:10.1007/s11892-015-0671-9

    authors: Fernyhough P

    更新日期:2015-11-01 00:00:00