The role of sodium channels in painful diabetic and idiopathic neuropathy.

abstract：:Hypertension and diabetes are independent risk factors for both cardiovascular disease and renal complications. Coexistence of these comorbid conditions predisposes the patient to a much greater risk of progression to end-stage renal disease. Combined with the increased cardiovascular mortality, this has led to recent...

journal_title：Current diabetes reports

authors： Newton CA,Raskin P

更新日期：2002-12-01 00:00:00

abstract：PURPOSE OF REVIEW:To introduce recent advances in the understanding of diabetic retinopathy and to summarize current and emerging strategies to treat this common and complex cause of vision loss. RECENT FINDINGS:Advances in retinal imaging and functional analysis indicate that retinal vascular and neural pathologies e...

journal_title：Current diabetes reports

authors： Honasoge A,Nudleman E,Smith M,Rajagopal R

更新日期：2019-09-10 00:00:00

abstract：:Diabetic retinopathy (DR) is a vision-threatening complication of diabetes. Timely diagnosis and intervention are essential for treatment that reduces the risk of vision loss. A good color retinal (fundus) photograph can be used as a surrogate for face-to-face evaluation of DR. The use of computers to assist or fully ...

journal_title：Current diabetes reports

authors： Li B,Li HK

更新日期：2013-08-01 00:00:00

abstract：:Pharmacologic doses of glucocorticoids and chronic renal failure are challenging comorbidities and complications for safe and effective dosing of insulin for the management of hospitalized patients with diabetes. Glucocorticoids are used widely in hospitalized patients and will commonly provoke new-onset hyperglycemia...

journal_title：Current diabetes reports

authors： Baldwin D,Apel J

更新日期：2013-02-01 00:00:00

abstract：PURPOSE OF REVIEW:The micro/macrovascular complications of diabetes cause considerable morbidity and premature mortality. The SGLT2 inhibitors are the first diabetes medications with significant benefits on microvascular disease (nephropathy) and macrovascular cardiovascular disease. In this review, we evaluate one of ...

journal_title：Current diabetes reports

authors： Ekanayake P,Hupfeld C,Mudaliar S

更新日期：2020-11-23 00:00:00

abstract：:In normal physiology, glucagon from pancreatic alpha cells plays an important role in maintaining glucose homeostasis via its regulatory effect on hepatic glucose production. Patients with type 2 diabetes suffer from fasting and postprandial hyperglucagonemia, which stimulate hepatic glucose production and, thus, cont...

journal_title：Current diabetes reports

authors： Lund A,Bagger JI,Christensen M,Knop FK,Vilsbøll T

更新日期：2014-12-01 00:00:00

abstract：:Bariatric surgery has emerged as the most durably effective treatment of type 2 diabetes (DM). However, the mechanisms governing improvement in glucose homeostasis have yet to be fully elucidated. In this review we discuss the various types of surgical interventions and the multitude of factors that potentially mediat...

journal_title：Current diabetes reports

authors： Nguyen KT,Korner J

更新日期：2014-01-01 00:00:00

abstract：:National guidelines indicate patients with elevated low- density lipoprotein cholesterol should consume less than 7% of calories from saturated fat and less than 200 mg of cholesterol. Trans fatty acids should also be limited. Incorporation of functional foods, such as stanol-containing margarine, soy products, and so...

journal_title：Current diabetes reports

authors： Carson JA

更新日期：2003-10-01 00:00:00

abstract：:Contrast-induced nephropathy (CIN) continues to be a significant complication of the increasing use of iodinated contrast media. There have been few new insights into pathogenesis; despite multiple strategies aimed at prophylaxis, very few have proven efficacious. This article reviews our current knowledge regarding C...

journal_title：Current diabetes reports

authors： Solomon R

更新日期：2007-12-01 00:00:00

abstract：PURPOSE OF REVIEW:This paper aims to examine how self-regulation (i.e., cognition, emotion) and social-regulation (i.e., parents, friends, romantic partners) are interrelated risk and protective factors for type 1 diabetes management during late adolescence and emerging adulthood. RECENT FINDINGS:Problems in cognitive...

journal_title：Current diabetes reports

authors： Wiebe DJ,Berg CA,Mello D,Kelly CS

更新日期：2018-03-21 00:00:00

abstract：:The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of type 2 diabetes mellitus to the chromosome 1q21-25 region in at least eight independent studies. More than 26 candidate genes have already been evaluated, but to date none explain the evidence for linkage in this gene-dense region....

journal_title：Current diabetes reports

authors： Das SK,Elbein SC

更新日期：2007-04-01 00:00:00

abstract：:Recent studies support the concept that the retinal vasculature may provide a summary measure of lifetime exposure to the effects of hyperglycemia. Advances in retinal photographic techniques and in image analysis have allowed objective and precise in vivo measurement of retinal vascular changes. In particular, quanti...

journal_title：Current diabetes reports

authors： Nguyen TT,Wong TY

更新日期：2009-08-01 00:00:00

abstract：:Suboptimal glycemic control is more common among non-Hispanic Blacks (NHBs) and Hispanics than non-Hispanic Whites (NHWs). Disparities in the performance of self-care behaviors may contribute to this. To synthesize knowledge on current self-care disparities, we reviewed studies from January 2011-March 2016 that includ...

journal_title：Current diabetes reports

authors： Mayberry LS,Bergner EM,Chakkalakal RJ,Elasy TA,Osborn CY

更新日期：2016-11-01 00:00:00

abstract：PURPOSE OF REVIEW:The increasing prevalence of type 2 diabetes is driving the boundaries of clinical diabetes care outside of the traditional office setting. The purpose of this paper will be to review recent technological advances in the medical management of people with type 2 diabetes, spanning the spectrum of care ...

journal_title：Current diabetes reports

authors： Grant AK,Golden L

更新日期：2019-12-20 00:00:00

abstract：:Both type 1 and type 2 diabetic patients have an increased incidence of ischemic heart disease and congestive heart failure. Cardiovascular disease accounts for up to 80% of the excess mortality in patients with type 2 diabetes. The burden of cardiovascular disease is especially pronounced in diabetic women. Factors t...

journal_title：Current diabetes reports

authors： Blendea MC,McFarlane SI,Isenovic ER,Gick G,Sowers JR

更新日期：2003-06-01 00:00:00

abstract：:Diabetic polyneuropathy (DPN) is the most common complication that emerges early in patients who have diabetes. Curative treatment for overt or symptomatic DPN has not been established, requiring much effort to explore new modalities. Thus, the use of various kinds of stem cells as a potential therapeutic option for D...

journal_title：Current diabetes reports

authors： Mizukami H,Yagihashi S

更新日期：2016-09-01 00:00:00

abstract：:Replacing dysfunctional endocrine tissues (eg, islets) with healthy, nonautologous material protected against the immune defense of the patient could soon become a reality. Recent advances have resulted in the development of alginate-based microcapsules that meet the demands of biocompatibility, long-term integrity, a...

journal_title：Current diabetes reports

authors： Zimmermann H,Shirley SG,Zimmermann U

更新日期：2007-08-01 00:00:00

abstract：PURPOSE OF REVIEW:This study aims to examine the operationalisation of 'psychological insulin resistance' (PIR) among people with type 2 diabetes and to identify and critique relevant measures. RECENT FINDINGS:PIR has been operationalised as (1) the assessment of attitudes or beliefs about insulin therapy and (2) hypo...

journal_title：Current diabetes reports

authors： Holmes-Truscott E,Pouwer F,Speight J

更新日期：2017-07-01 00:00:00

abstract：PURPOSE OF REVIEW:Gestational diabetes (GDM) is associated with adverse pregnancy and neonatal outcomes and increased maternal risk for subsequent type 2 diabetes. The best diagnostic strategy for GDM is debated and the role of oral antidiabetic medications (OAD) for treatment is unclear. In this paper, we review metho...

journal_title：Current diabetes reports

authors： Dickens LT,Thomas CC

更新日期：2019-05-09 00:00:00

abstract：:Unfortunately, the only approved medical treatment for type 1 diabetes mellitus (DM) is insulin, despite the fact that tight control cannot be reached without some serious side effects such as hypoglycemia and weight gain. More and more importance is now shifted towards developing new drugs that can reach a better gly...

journal_title：Current diabetes reports

authors： Issa CM,Azar ST

更新日期：2012-10-01 00:00:00

abstract：:As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...

journal_title：Current diabetes reports

authors： Puri R,Kataoka Y,Uno K,Nicholls SJ

更新日期：2012-06-01 00:00:00

abstract：:Peripheral sensory neuropathy (PSN) and foot ulcers are disabling and expensive complications of diabetes with few therapeutic options. Knowledge of risk factors for both complications, based on prospective observational studies, permits identification of individuals at high risk and provides options for intervention....

journal_title：Current diabetes reports

authors： Adler A

更新日期：2001-12-01 00:00:00

abstract：PURPOSE OF REVIEW:The global prevalence of obesity has increased rapidly over the last decades, posing a severe threat to human health. Currently, bariatric surgery is the most effective therapy for patients with morbid obesity. It is unknown whether this treatment is also suitable for patients with obesity due to a co...

journal_title：Current diabetes reports

authors： Vos N,Oussaada SM,Cooiman MI,Kleinendorst L,Ter Horst KW,Hazebroek EJ,Romijn JA,Serlie MJ,Mannens MMAM,van Haelst MM

更新日期：2020-07-30 00:00:00

abstract：:The coexistence of type 2 diabetes and obesity presents a complex therapeutic challenge. Future combination tablets may include agents to address diabetes and any accompanying cardiovascular risk factors. Injectable agents that improve glycemic control and facilitate weight loss have recently become available: the sol...

journal_title：Current diabetes reports

authors： Bailey CJ

更新日期：2005-10-01 00:00:00

abstract：PURPOSE OF REVIEW:Review innovations in health care financing promoting health system investments in addressing medical and social determinants of health (SDH) for patients with diabetes. RECENT FINDINGS:Particular payment models implemented in the public and private sectors increasingly offer flexibility in health ca...

journal_title：Current diabetes reports

authors： Saulsberry L,Peek M

更新日期：2019-11-20 00:00:00

abstract：:A large body of evidence indicates that the risk for developing chronic diabetic complications is under the control of genetic factors. Previous studies using a candidate gene approach have uncovered a number of genetic loci that may shape this risk, such as the VEGF gene for retinopathy, the ELMO1 gene for nephropath...

journal_title：Current diabetes reports

authors： Doria A

更新日期：2010-12-01 00:00:00

abstract：:The treatment of painful diabetic polyneuropathy (PDPN) remains a major challenge. A number of reasons have made the guidelines on PDPN management of particular interest, including its high prevalence, health and socioeconomic impact, interdisciplinary nature and the need for updated evidence-based information to refi...

journal_title：Current diabetes reports

authors： Spallone V

更新日期：2012-08-01 00:00:00

abstract：:Diabetic neuropathy is the most common microvascular complication of diabetes mellitus with high morbidity and mortality, and low quality of life. It has a broad spectrum of clinical forms, although distal symmetrical polyneuropathy is the most prevalent. Several oral complications including burning mouth syndrome, dr...

journal_title：Current diabetes reports

authors： Borgnakke WS,Anderson PF,Shannon C,Jivanescu A

更新日期：2015-11-01 00:00:00

abstract：PURPOSE OF REVIEW:Currently, the diagnosis of gestational diabetes mellitus (GDM) lacks uniformity. Several controversies are still under debate, especially on the method of screening and diagnosis. This review focuses on recent literature and provides current evidence for the screening and diagnosis of GDM. RECENT FI...

journal_title：Current diabetes reports

authors： Kuo CH,Li HY

更新日期：2019-12-04 00:00:00

abstract：:Comparative results from national strategies for diabetes care and prevention are needed to understand the impact and barriers encountered during the implementation process. Long-term outcomes are limited, but results on intermediate outcomes and processes of diabetes care measures are available from translational res...

journal_title：Current diabetes reports

authors： Haw JS,Tantry S,Vellanki P,Pasquel FJ

更新日期：2015-09-01 00:00:00