Abstract：
:Lipodystrophies are a genetically heterogeneous group of disorders characterized by loss of subcutaneous adipose tissue and metabolic dysfunction, including insulin resistance, increased levels of free fatty acids, abnormal adipocytokine secretion, and ectopic fat deposition, which are also observed in patients with visceral obesity and/or type 2 diabetes mellitus. Pathophysiological, biochemical, and genetic studies suggest that impairment in multiple adipose tissue functions, including adipocyte maturation, lipid storage, formation and/or maintenance of the lipid droplet, membrane composition, DNA repair efficiency, and insulin signaling, results in severe metabolic and endocrine consequences, ultimately leading to specific lipodystrophic phenotypes. In this review, recent evidences on the causes and metabolic processes of lipodystrophies will be presented, proposing a disease model that could be potentially informative for better understanding of common metabolic diseases in humans, including obesity, metabolic syndrome, and type 2 diabetes.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Ficarella R,Laviola L,Giorgino Fdoi
10.1007/s11892-015-0578-5subject
Has Abstractpub_date
2015-03-01 00:00:00pages
12issue
3eissn
1534-4827issn
1539-0829journal_volume
15pub_type
杂志文章,评审abstract：:Among the spectrum of risk for diabetic foot disease conferred by chronic kidney disease (CKD), end-stage renal disease (ESRD) has emerged as a novel independent risk factor. Apart from the classical triad of neuropathy, infection, and peripheral arterial disease that operate in these individuals, the risk is further ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-010-0128-0
更新日期：2010-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Obesity is increasing at an alarming rate and now poses a global threat to humankind. In recent years, we have seen the emergence of medical devices to combat the obesity epidemic. These therapeutic strategies are discussed in this review dividing them into gastric and duodenal therapies. RECENT FIND...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1217-3
更新日期：2019-08-30 00:00:00
abstract：PURPOSE OF REVIEW:Evidence-based treatments for prediabetes can prevent and delay the development of type 2 diabetes in adults. In this review, we propose a framework for population-based diabetes prevention that links screening and prevention activities across key stakeholders. We also discuss gaps in current practice...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1090-5
更新日期：2018-09-19 00:00:00
abstract：PURPOSE OF REVIEW:Soon after the first genome-wide association study (GWAS) for type 2 diabetes (T2D) was published, it was hypothesized that rare and low-frequency variants might explain a substantial proportion of disease risk. Rare coding variants in particular were emphasized given their large expected role in dise...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1142-5
更新日期：2019-04-08 00:00:00
abstract：PURPOSE OF REVIEW:The purpose of the study is to examine and summarize studies reporting on the epidemiology, the risk of developing diabetes, and the cardiovascular effects on individuals with diabetes of different levels of alcohol consumption. RECENT FINDINGS:Men consume more alcohol than women in populations with ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-017-0950-8
更新日期：2017-11-04 00:00:00
abstract：:Type 2 diabetes is the result of a progressive impairment of pancreatic beta-cell function in the setting of worsening insulin resistance. Studies in high-risk populations have demonstrated that during progression to diabetes, beta cells have declining function and lose the first phase of insulin secretion, resulting ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-004-0019-3
更新日期：2004-06-01 00:00:00
abstract：:Type 1 diabetes (T1D) is a complex autoimmune disease, and first stages of the disease typically develop early in life. Genetic as well as environmental factors are thought to contribute to the risk of developing autoimmunity against pancreatic beta cells. Several environmental factors, such as breastfeeding or early ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0753-3
更新日期：2016-07-01 00:00:00
abstract：:The diabetes and obesity epidemics have stimulated research to assess the benefits and potential risks of low-carbohydrate diets. Carbohydrate comprises less than 45% of calories in carbohydrate-restricted diets, but very low carbohydrate ketogenic diets may restrict carbohydrate to 20 g initially with variability in ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-009-0061-2
更新日期：2009-10-01 00:00:00
abstract：:Type 1 diabetes (T1D) is a complex chronic disease that has many facets for successful management. The burden of this management falls largely on the individual and their family members. Self-management has a major influence on T1D health outcomes, and with successful management, children and adolescents with T1D can ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0544-7
更新日期：2014-01-01 00:00:00
abstract：:Erectile dysfunction (ED) is more commonly seen in men with various components of the metabolic syndrome (a constellation of various cardiovascular and diabetes risk factors). ED can be considered as a risk marker of the metabolic syndrome and its associated conditions. The patient with ED should be thoroughly evaluat...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-005-0070-8
更新日期：2005-02-01 00:00:00
abstract：:Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by the loss of beta-cell secretory function and mass. The pathophysiology of beta-cell failure in T2DM involves a complex interaction between genetic susceptibilities and environmental risk factors. One environmental condition that is gaining...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0474-4
更新日期：2014-04-01 00:00:00
abstract：PURPOSE OF REVIEW:Obesity and diabetes are worldwide epidemics. There is also a growing body of evidence relating the gut microbiome composition to insulin resistance. The purpose of this review is to delineate the studies linking gut microbiota to obesity, metabolic syndrome, and diabetes. RECENT FINDINGS:Animal stud...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1104-3
更新日期：2018-10-18 00:00:00
abstract：:As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, poly...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-012-0270-y
更新日期：2012-06-01 00:00:00
abstract：:Impaired glucose tolerance (IGT) is characterized by plasma glucose responses to an oral glucose challenge that are above normal but not at the level defining diabetes. IGT is a common condition that greatly increases risk for the subsequent development of type 2 diabetes. Individuals with IGT manifest abnormalities i...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-002-0090-6
更新日期：2002-06-01 00:00:00
abstract：PURPOSE OF REVIEW:The oral glucose tolerance test (OGTT) is used both in clinical practice and research to assess glucose tolerance. In addition, the OGTT is utilized for surrogate measures of insulin sensitivity and the insulin response to enteral glucose and has been widely applied in the evaluation of β-cell dysfunc...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1023-3
更新日期：2018-06-16 00:00:00
abstract：:Attention to meal-related insulin replacement in type 2 diabetes is important as insulin deficiency progresses. The physiology in type 2 and type 1 diabetes differs, and optimal use of basal-bolus therapy in type 2 diabetes requires attention to such issues as the role for oral medications, residual endogenous insulin...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-004-0037-1
更新日期：2004-10-01 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) plays a pivotal role in the development of diabetic macular edema (DME), the leading cause of vision loss among working-aged individuals. A decade of clinical trials demonstrated that drugs that bind soluble VEGF restore the integrity of the blood-retinal barrier, resolve macu...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-014-0510-4
更新日期：2014-08-01 00:00:00
abstract：PURPOSE OF REVIEW:Our review provides a brief summary of the most recent advances towards the identification of the genetic basis of specific aspects of obesity and the quantification of their consequences on health. We also highlight the most promising avenues to be explored in the future. RECENT FINDINGS:While obesi...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-020-1285-4
更新日期：2020-01-22 00:00:00
abstract：:Worldwide increases in diabetes prevalence in the face of limited medical resources have prompted international interest in innovative healthcare delivery models. Project ECHO (Extension for Community Healthcare Outcomes) is a "telementoring" program which has been shown to increase capacity for complex disease manage...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0784-9
更新日期：2016-10-01 00:00:00
abstract：PURPOSE OF REVIEW:Ambient air pollution is strongly linked to cardiovascular and respiratory diseases. We summarize available published evidence regarding similar associations with diabetes across the life course. RECENT FINDINGS:We performed a life-course survey of the recent literature, including prenatal, gestation...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1181-y
更新日期：2019-07-19 00:00:00
abstract：:According to a 2010 national survey, 11 % of adults in China have diabetes, affecting 109.6 million individuals. The high prevalence of diabetes has been attributed to the aging of the population, the rapid adoption of energy-dense foods, and a reduction in physical activity. Collectively, these secular changes have c...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-016-0821-8
更新日期：2016-12-01 00:00:00
abstract：PURPOSE OF REVIEW:Gestational diabetes (GDM) is associated with adverse pregnancy and neonatal outcomes and increased maternal risk for subsequent type 2 diabetes. The best diagnostic strategy for GDM is debated and the role of oral antidiabetic medications (OAD) for treatment is unclear. In this paper, we review metho...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-019-1147-0
更新日期：2019-05-09 00:00:00
abstract：:Since their introduction, insulin analogues are the preferred choice for short-acting insulin due to their superior pharmacologic profiles, leading to greater flexibility and convenience of dosing and, thus, greater patient satisfaction and improved quality of life. Over the past few years, clinical experience with in...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-010-0160-0
更新日期：2011-02-01 00:00:00
abstract：PURPOSES OF REVIEW:Extracellular matrix (ECM) components modulate the interaction between pancreatic islet cells. During the islet isolation prior to transplantation as treatment for type 1 diabetes, the ECM is disrupted impacting functional graft survival. Recently, strategies for restoring ECM have shown to improve t...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1014-4
更新日期：2018-05-19 00:00:00
abstract：PURPOSE:The measurement and estimation of diabetes in populations guides resource allocation, health priorities, and can influence practice and future research. To provide a critical reflection on current diabetes surveillance, we provide in-depth discussion about how upstream determinants, prevalence, incidence, and d...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-018-1088-z
更新日期：2018-09-19 00:00:00
abstract：:The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-012-0347-7
更新日期：2013-02-01 00:00:00
abstract：:Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and acti...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-015-0605-6
更新日期：2015-06-01 00:00:00
abstract：:About 10% of patients with the clinical presentation of type 2 diabetes suffer from an autoimmune form of diabetes associated with a rapid decline of residual beta-cell mass and subsequent development of insulin dependency. In this condition, called latent autoimmune diabetes in adults (LADA), there are clinical and m...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-008-0018-x
更新日期：2008-04-01 00:00:00
abstract：:Diabetic nephropathy is the leading cause of renal failure in industrialized countries. There is strong evidence that diabetic nephropathy is influenced by genetic factors. Studies in the Pima Indians as well as in other populations demonstrate that diabetic nephropathy aggregates in families. The hypothesis that the ...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-001-0046-2
更新日期：2001-12-01 00:00:00
abstract：:The cardiovascular risk associated with the polycystic ovary syndrome (PCOS) has recently attracted much interest. Women with PCOS are more likely to fulfill the diagnosis of the metabolic syndrome, a cluster of related cardiometabolic factors known to predict long-term risk of cardiovascular disease and type 2 diabet...
journal_title：Current diabetes reports
pub_type： 杂志文章,评审
doi：10.1007/s11892-007-0012-8
更新日期：2007-02-01 00:00:00
