Abstract:
:Diabetic nephropathy is the leading cause of renal failure in industrialized countries. There is strong evidence that diabetic nephropathy is influenced by genetic factors. Studies in the Pima Indians as well as in other populations demonstrate that diabetic nephropathy aggregates in families. The hypothesis that the familial aggregation reflects the effect of a major gene was formally tested by segregation analysis of diabetic nephropathy in Pima Indians with type 2 diabetes. The segregation analysis provided strong evidence for a major genetic effect on the prevalence of diabetic nephropathy; this suggests that some of the genetic determinants of diabetic nephropathy may have effects of sufficient magnitude to be detected by linkage analysis. Therefore, we analyzed data from a genome-wide scan to identify susceptibility loci for nephropathy in diabetic Pima Indians. Analyses conducted by both parametric (model-based) and nonparametric methods revealed tentative evidence for nephropathy susceptibility loci on chromosomes 3q, 7q, 18q, and 20p.
journal_name
Curr Diab Repjournal_title
Current diabetes reportsauthors
Imperatore G,Knowler WC,Nelson RG,Hanson RLdoi
10.1007/s11892-001-0046-2keywords:
subject
Has Abstractpub_date
2001-12-01 00:00:00pages
275-81issue
3eissn
1534-4827issn
1539-0829journal_volume
1pub_type
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journal_title:Current diabetes reports
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:Current diabetes reports
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章
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更新日期:2012-10-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0287-2
更新日期:2012-08-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2005-10-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2018-11-08 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2014-03-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2004-08-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2004-06-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01311-1
更新日期:2020-05-26 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2013-02-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2019-07-20 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2018-02-15 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2012-06-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2017-07-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-001-0035-5
更新日期:2001-12-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2015-03-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-015-0605-6
更新日期:2015-06-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-012-0336-x
更新日期:2013-02-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Current diabetes reports
pub_type: 杂志文章,评审
doi:10.1007/s11892-020-01344-6
更新日期:2020-09-28 00:00:00